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Protein Overview: ROG3

General Information:
Name(s) found: ROG3 / YFR022W [SGD]
Description(s) found:
Found 26 descriptions.
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  • Protein that binds the ubiquitin ligase Rsp5p via its 2 PY motifs; has similarity to Rod1p; mutation suppresses the temperature sensitivity of an mck1 rim11 double mutant; proposed to regulate the endocytosis of plasma membrane proteins [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 733 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: biological_process [ND]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGFSSGKSTK KKPLLFDIRL KNVDNDVILL KGPPNEAPSV LLSGCIVLSI NEPMQIKSIS  60
   61 LRLYGKIQID VPLERPQDAS SSSLSSSPPK IRKYNKVFYN YAWDNVNLKE YLSGLRGQSG 120
  121 LAGSSSSSNI LGTRQRAQST SSLKSLKGSS SPSSCTLDKG NYDFPFSAIL PGSLPESVES 180
  181 LPNCFVTYSM ESVIERSKNY SDLICRKNIR VLRTISPAAV ELSETVCVDN SWPDKVDYSI 240
  241 SVPNKAVAIG SATPINISIV PLSKGLKLGS IKVVLFENYQ YCDPFPPVIS ENRQVTELNL 300
  301 EDPLNESSGE FNGNGCFVNN PFFQPDHSFQ DKWEIDTILQ IPNSLSNCVQ DCDVRSNIKV 360
  361 RHKLKFFIIL INPDGHKSEL RASLPIQLFI SPFVALSIKP LSSSNLYSLF STTNQKDENS 420
  421 SQEEEEEYLF SRSASVTGLE LLADMRSGGS VPTISDLMTP PNYEMHVYDR LYSGSFTRTA 480
  481 VETSGTCTPL GSECSTVEDQ QQDLEDLRIR LTKIRNQRDN LGLPPSASSA AASRSLSPLL 540
  541 NVPAPEDGTE RILPQSALGP NSGSVPGVHS NVSPVLLSRS PAPSVSAHEV LPVPSGLNYP 600
  601 ETQNLNKVPS YGKAMKYDII GEDLPPSYPC AIQNVQPRKP SRVHSRNSST TLSSSIPTSF 660
  661 HSSSFMSSTA SPISIINGSR SSSSGVSLNT LNELTSKTSN NPSSNSMKRS PTRRRATSLA 720
  721 GFMGGFLSKG NKR

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) CTP1 ERV25 FKS1 FTR1 MRH1 OLE1 PEX27 ROG3 RPL10 RPL36B RPL37A RPP1A SEC11 SPC1 SPC2 SPC3 TCM62 TSC13 YNR021W

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #21 Asynchronous Prep2-IMAC Phosphopeptide enrichment A1 Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..132] MSA 2.065995 View MSA. No confident structure predictions are available.
    2 View Details [133..199]
    [277..293]
    [313..361]    		 PSI-BLAST 64.522879 Arrestin
    3 View Details [200..276]
    [294..312]
    [362..444]    		 PSI-BLAST 64.522879 Arrestin
    4 View Details [445..733] MSA 20.136997 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.88

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle