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Protein Overview: GAL10

General Information:
Name(s) found: GAL10 / YBR019C [SGD]
Description(s) found:
Found 24 descriptions.
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  • UDP-glucose-4-epimerase, catalyzes the interconversion of UDP-galactose and UDP-D-glucose in galactose metabolism; also catalyzes the conversion of alpha-D-glucose or alpha-D-galactose to their beta-anomers [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 699 amino acids

    Gene Ontology:
    Cellular Component: soluble fraction [IDALink to PubMed article]
    Biological Process: galactose catabolic process [IDALink to PubMed article][IMPLink to PubMed article]
    Molecular Function: UDP-glucose 4-epimerase activity [IDALink to PubMed article][IMPLink to PubMed article]
    aldose 1-epimerase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTAQLQSEST SKIVLVTGGA GYIGSHTVVE LIENGYDCVV ADNLSNSTYD SVARLEVLTK  60
   61 HHIPFYEVDL CDRKGLEKVF KEYKIDSVIH FAGLKAVGES TQIPLRYYHN NILGTVVLLE 120
  121 LMQQYNVSKF VFSSSATVYG DATRFPNMIP IPEECPLGPT NPYGHTKYAI ENILNDLYNS 180
  181 DKKSWKFAIL RYFNPIGAHP SGLIGEDPLG IPNNLLPYMA QVAVGRREKL YIFGDDYDSR 240
  241 DGTPIRDYIH VVDLAKGHIA ALQYLEAYNE NEGLCREWNL GSGKGSTVFE VYHAFCKASG 300
  301 IDLPYKVTGR RAGDVLNLTA KPDRAKRELK WQTELQVEDS CKDLWKWTTE NPFGYQLRGV 360
  361 EARFSAEDMR YDARFVTIGA GTRFQATFAN LGASIVDLKV NGQSVVLGYE NEEGYLNPDS 420
  421 AYIGATIGRY ANRISKGKFS LCNKDYQLTV NNGVNANHSS IGSFHRKRFL GPIIQNPSKD 480
  481 VFTAEYMLID NEKDTEFPGD LLVTIQYTVN VAQKSLEMVY KGKLTAGEAT PINLTNHSYF 540
  541 NLNKPYGDTI EGTEIMVRSK KSVDVDKNMI PTGNIVDREI ATFNSTKPTV LGPKNPQFDC 600
  601 CFVVDENAKP SQINTLNNEL TLIVKAFHPD SNITLEVLST EPTYQFYTGD FLSAGYEARQ 660
  661 GFAIEPGRYI DAINQENWKD CVTLKNGETY GSKIVYRFS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) APL2 APL4 APM1 APM2 APS1 CST26 GAL10 IRC6 YFL034W

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..137]
    [158..191]
    [254..278]    		 PSI-BLAST 1160.0 Uridine diphosphogalactose-4-epimerase (UDP-galactose 4-epimerase)
    2 View Details [138..157]
    [192..196]
    [247..253]
    [279..285]
    [314..335]    		 PSI-BLAST 1160.0 Uridine diphosphogalactose-4-epimerase (UDP-galactose 4-epimerase)
    3 View Details [197..246]
    [286..313]
    [336..366]    		 PSI-BLAST 1160.0 Uridine diphosphogalactose-4-epimerase (UDP-galactose 4-epimerase)
    4 View Details [367..699] PSI-BLAST 244.67837 Galactose mutarotase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • aldose 1-epimerase activity
    		•  2.85100059704396 bayes_pls_golite062009
  • UDP-glucose 4-epimerase activity
    		•  2.13934644118967 bayes_pls_golite062009
  • catalytic activity
    		•  1.79741889688267 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH-OH group of donors
    		•  1.03956654822048 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.868888700854563 bayes_pls_golite062009
  • binding
    		•  0.835119783772935 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  0.82673050487418 bayes_pls_golite062009
  • DNA binding
    		•  0.790382977752475 bayes_pls_golite062009
  • alcohol dehydrogenase (NAD) activity
    		•  0.65743456407889 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.613310508772122 bayes_pls_golite062009
  • retinol dehydrogenase activity
    		•  0.48941662111046 bayes_pls_golite062009
  • NAD or NADH binding
    		•  0.44922383360529 bayes_pls_golite062009
  • coenzyme binding
    		•  0.35922330382799 bayes_pls_golite062009
  • transcription factor activity
    		•  0.11102650759187 bayes_pls_golite062009
  • hydrolase activity, acting on glycosyl bonds
    		•  0.0498966688564807 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle