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Protein Overview: PBPB_ECOLI

General Information:
Name(s) found: PBPB_ECOLI [Swiss-Prot]
Description(s) found:
Found 6 descriptions.
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  • Penicillin-binding protein 1B (PBP-1b) (PBP1b) (Murein polymerase) [Includes: Penicillin-insensitive transglycosylase (EC 2.4.1.129) (Peptidoglycan glycosyltransferase) (Peptidoglycan TGase); Penicillin-sensitive transpeptidase (EC 3.4.-.-) (DD-transpepti [Swiss-Prot]
    • Organism: Escherichia coli
    Length: 844 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAGNDREPIG RKGKPTRPVK QKVSRRRYED DDDYDDYDDY EDEEPMPRKG KGKGKGRKPR  60
   61 GKRGWLWLLL KLAIVFAVLI AIYGVYLDQK IRSRIDGKVW QLPAAVYGRM VNLEPDMTIS 120
  121 KNEMVKLLEA TQYRQVSKMT RPGEFTVQAN SIEMIRRPFD FPDSKEGQVR ARLTFDGDHL 180
  181 ATIVNMENNR QFGFFRLDPR LITMISSPNG EQRLFVPRSG FPDLLVDTLL ATEDRHFYEH 240
  241 DGISLYSIGR AVLANLTAGR TVQGASTLTQ QLVKNLFLSS ERSYWRKANE AYMALIMDAR 300
  301 YSKDRILELY MNEVYLGQSG DNEIRGFPLA SLYYFGRPVE ELSLDQQALL VGMVKGASIY 360
  361 NPWRNPKLAL ERRNLVLRLL QQQQIIDQEL YDMLSARPLG VQPRGGVISP QPAFMQLVRQ 420
  421 ELQAKLGDKV KDLSGVKIFT TFDSVAQDAA EKAAVEGIPA LKKQRKLSDL ETAIVVVDRF 480
  481 SGEVRAMVGG SEPQFAGYNR AMQARRSIGS LAKPATYLTA LSQPKIYRLN TWIADAPIAL 540
  541 RQPNGQVWSP QNDDRRYSES GRVMLVDALT RSMNVPTVNL GMALGLPAVT ETWIKLGVPK 600
  601 DQLHPVPAML LGALNLTPIE VAQAFQTIAS GGNRAPLSAL RSVIAEDGKV LYQSFPQAER 660
  661 AVPAQAAYLT LWTMQQVVQR GTGRQLGAKY PNLHLAGKTG TTNNNVDTWF AGIDGSTVTI 720
  721 TWVGRDNNQP TKLYGASGAM SIYQRYLANQ TPTPLNLVPP EDIADMGVDY DGNFVCSGGM 780
  781 RILPVWTSDP QSLCQQSEMQ QQPSGNPFDQ SSQPQQQPQQ QPAQQEQKDS DGVAGWIKDM 840
  841 FGSN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..174] PSI-BLAST 40.0 No description for 2fdcA was found.
    2 View Details [175..844] PSI-BLAST 108.0 No description for 2oluA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  1.8576045268999 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.899518010026156 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.85586999556549 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.834450827636679 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.83347444578978 bayes_pls_golite062009
  • catalytic activity
    		•  0.458437698837681 bayes_pls_golite062009
  • protein binding
    		•  0.378225828131122 bayes_pls_golite062009
  • hydrolase activity
    		•  0.0674634697044169 bayes_pls_golite062009
  • nucleotide binding
    		•  0.0601614967638421 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.0518926528648858 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.0231586743339878 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.0231035204040646 bayes_pls_golite062009
    2
    Term Confidence Notes
  • drug binding
    		•  3.68379051298286 bayes_pls_golite062009
  • serine-type D-Ala-D-Ala carboxypeptidase activity
    		•  3.12650314537616 bayes_pls_golite062009
  • penicillin binding
    		•  2.89507018520983 bayes_pls_golite062009
  • serine-type carboxypeptidase activity
    		•  2.70174066798582 bayes_pls_golite062009
  • serine-type exopeptidase activity
    		•  2.69091897402517 bayes_pls_golite062009
  • carboxypeptidase activity
    		•  1.96547160092829 bayes_pls_golite062009
  • catalytic activity
    		•  1.85492008367309 bayes_pls_golite062009
  • hydrolase activity, hydrolyzing O-glycosyl compounds
    		•  1.71682392634357 bayes_pls_golite062009
  • hydrolase activity, acting on glycosyl bonds
    		•  1.62647051069622 bayes_pls_golite062009
  • exopeptidase activity
    		•  1.44522375970439 bayes_pls_golite062009
  • binding
    		•  0.967786931456022 bayes_pls_golite062009
  • protein binding
    		•  0.274057433888583 bayes_pls_golite062009
  • peptidase activity
    		•  0.231714711049091 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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