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Protein Overview: ACRF_ECOLI

General Information:
Name(s) found: ACRF_ECOLI [Swiss-Prot]
Description(s) found:
Found 10 descriptions.
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  • Acriflavine resistance protein F (Protein envD) - Escherichia coli [Swiss-Prot]
    • Organism: Escherichia coli
    Length: 1034 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MANFFIRRPI FAWVLAIILM MAGALAILQL PVAQYPTIAP PAVSVSANYP GADAQTVQDT  60
   61 VTQVIEQNMN GIDNLMYMSS TSDSAGSVTI TLTFQSGTDP DIAQVQVQNK LQLATPLLPQ 120
  121 EVQQQGISVE KSSSSYLMVA GFVSDNPGTT QDDISDYVAS NVKDTLSRLN GVGDVQLFGA 180
  181 QYAMRIWLDA DLLNKYKLTP VDVINQLKVQ NDQIAAGQLG GTPALPGQQL NASIIAQTRF 240
  241 KNPEEFGKVT LRVNSDGSVV RLKDVARVEL GGENYNVIAR INGKPAAGLG IKLATGANAL 300
  301 DTAKAIKAKL AELQPFFPQG MKVLYPYDTT PFVQLSIHEV VKTLFEAIML VFLVMYLFLQ 360
  361 NMRATLIPTI AVPVVLLGTF AILAAFGYSI NTLTMFGMVL AIGLLVDDAI VVVENVERVM 420
  421 MEDKLPPKEA TEKSMSQIQG ALVGIAMVLS AVFIPMAFFG GSTGAIYRQF SITIVSAMAL 480
  481 SVLVALILTP ALCATLLKPV SAEHHENKGG FFGWFNTTFD HSVNHYTNSV GKILGSTGRY 540
  541 LLIYALIVAG MVVLFLRLPS SFLPEEDQGV FLTMIQLPAG ATQERTQKVL DQVTDYYLKN 600
  601 EKANVESVFT VNGFSFSGQA QNAGMAFVSL KPWEERNGDE NSAEAVIHRA KMELGKIRDG 660
  661 FVIPFNMPAI VELGTATGFD FELIDQAGLG HDALTQARNQ LLGMAAQHPA SLVSVRPNGL 720
  721 EDTAQFKLEV DQEKAQALGV SLSDINQTIS TALGGTYVND FIDRGRVKKL YVQADAKFRM 780
  781 LPEDVDKLYV RSANGEMVPF SAFTTSHWVY GSPRLERYNG LPSMEIQGEA APGTSSGDAM 840
  841 ALMENLASKL PAGIGYDWTG MSYQERLSGN QAPALVAISF VVVFLCLAAL YESWSIPVSV 900
  901 MLVVPLGIVG VLLAATLFNQ KNDVYFMVGL LTTIGLSAKN AILIVEFAKD LMEKEGKGVV 960
  961 EATLMAVRMR LRPILMTSLA FILGVLPLAI SNGAGSGAQN AVGIGVMGGM VSATLLAIFF1020
 1021 VPVFFVVIRR CFKG

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..1034] PSI-BLAST 1000.0 Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains; Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains; Multidrug efflux transporter AcrB transmembrane domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transporter activity
    		•  2.93091397928047 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.82224868778929 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.95102182117705 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.86091881396874 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  1.79083094640891 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  1.72792205593593 bayes_pls_golite062009
  • drug transmembrane transporter activity
    		•  1.51403675564591 bayes_pls_golite062009
    		• 1.44001556200678 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  1.1603277826799 bayes_pls_golite062009
    		• 1.01602145525561 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.769769685601419 bayes_pls_golite062009
  • efflux transmembrane transporter activity
    		•  0.21543973486818 bayes_pls_golite062009
  • antiporter activity
    		•  0.0217133902283497 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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