YRC Public Data Repository - Protein Structure Prediction

Protein:	ACRF_ECOLI
Organism:	Escherichia coli
Length:	1034 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ACRF_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|82545637, gi\|... - gi\|82545637\|ref\|YP_409584.1\| integral transmembrane protein [Shigella boydii Sb227], gi\|81247048\|gb\|...	874.0	[0..1]	[1034..1]
gi\|13539232 - gi\|13539232\|emb\|CAC35725.1\| AcrB protein [Enterobacter aerogenes]	867.0	[0..1]	[1018..1]
gi\|148807120, gi... - gi\|148807120\|gb\|ABR13271.1\| AcrB [Enterobacter cloacae], gi\|112182849\|emb\|CAL18626.1\| AcrB protein [...	865.0	[0..1]	[1018..1]
gi\|75229208, gi\|... - gi\|75229208\|ref\|ZP_00715776.1\| COG0841: Cation/multidrug efflux pump [Escherichia coli B7A], gi\|1911... gi\|209919942, gi... - gi\|209919942\|ref\|YP_002294026.1\| aminoglycoside/multidrug efflux system [Escherichia coli SE11], gi\|...	865.0	[0..1]	[1032..1]
gi\|188487998, gi... - gi\|75511212\|ref\|ZP_00733919.1\| COG0841: Cation/multidrug efflux pump [Escherichia coli 53638], gi\|18...	864.0	[0..1]	[1034..1]
gi\|157162747, gi... - gi\|157162747\|ref\|YP_001460065.1\| acriflavine resistance protein F [Escherichia coli HS], gi\|15706842... gi\|194440028, gi... - gi\|83584628\|ref\|ZP_00923296.1\| COG0841: Cation/multidrug efflux pump [Escherichia coli 101-1], gi\|19...	864.0	[0..1]	[1034..1]
gi\|191172943, gi... - gi\|75240119\|ref\|ZP_00724078.1\| COG0841: Cation/multidrug efflux pump [Escherichia coli F11], gi\|1911...	863.0	[0..1]	[1032..1]
gi\|26110286, gi\|... - gi\|26249858\|ref\|NP_755898.1\| acriflavin resistance protein F [Escherichia coli CFT073], gi\|26110286\|...	863.0	[0..1]	[1034..1]
gi\|157080537, gi... - gi\|75187214\|ref\|ZP_00700481.1\| COG0841: Cation/multidrug efflux pump [Escherichia coli E24377A], gi\|...	863.0	[0..1]	[1032..1]

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Predicted Domain #1

Region A:
Residues: [1-1034]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MANFFIRRPI FAWVLAIILM MAGALAILQL PVAQYPTIAP PAVSVSANYP GADAQTVQDT  60
   61 VTQVIEQNMN GIDNLMYMSS TSDSAGSVTI TLTFQSGTDP DIAQVQVQNK LQLATPLLPQ 120
  121 EVQQQGISVE KSSSSYLMVA GFVSDNPGTT QDDISDYVAS NVKDTLSRLN GVGDVQLFGA 180
  181 QYAMRIWLDA DLLNKYKLTP VDVINQLKVQ NDQIAAGQLG GTPALPGQQL NASIIAQTRF 240
  241 KNPEEFGKVT LRVNSDGSVV RLKDVARVEL GGENYNVIAR INGKPAAGLG IKLATGANAL 300
  301 DTAKAIKAKL AELQPFFPQG MKVLYPYDTT PFVQLSIHEV VKTLFEAIML VFLVMYLFLQ 360
  361 NMRATLIPTI AVPVVLLGTF AILAAFGYSI NTLTMFGMVL AIGLLVDDAI VVVENVERVM 420
  421 MEDKLPPKEA TEKSMSQIQG ALVGIAMVLS AVFIPMAFFG GSTGAIYRQF SITIVSAMAL 480
  481 SVLVALILTP ALCATLLKPV SAEHHENKGG FFGWFNTTFD HSVNHYTNSV GKILGSTGRY 540
  541 LLIYALIVAG MVVLFLRLPS SFLPEEDQGV FLTMIQLPAG ATQERTQKVL DQVTDYYLKN 600
  601 EKANVESVFT VNGFSFSGQA QNAGMAFVSL KPWEERNGDE NSAEAVIHRA KMELGKIRDG 660
  661 FVIPFNMPAI VELGTATGFD FELIDQAGLG HDALTQARNQ LLGMAAQHPA SLVSVRPNGL 720
  721 EDTAQFKLEV DQEKAQALGV SLSDINQTIS TALGGTYVND FIDRGRVKKL YVQADAKFRM 780
  781 LPEDVDKLYV RSANGEMVPF SAFTTSHWVY GSPRLERYNG LPSMEIQGEA APGTSSGDAM 840
  841 ALMENLASKL PAGIGYDWTG MSYQERLSGN QAPALVAISF VVVFLCLAAL YESWSIPVSV 900
  901 MLVVPLGIVG VLLAATLFNQ KNDVYFMVGL LTTIGLSAKN AILIVEFAKD LMEKEGKGVV 960
  961 EATLMAVRMR LRPILMTSLA FILGVLPLAI SNGAGSGAQN AVGIGVMGGM VSATLLAIFF1020
 1021 VPVFFVVIRR CFKG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1000.0
Match:	1oy6A
Description:	Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains; Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains; Multidrug efflux transporter AcrB transmembrane domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transporter activity	2.93091397928047	bayes_pls_golite062009
transmembrane transporter activity	2.82224868778929	bayes_pls_golite062009
substrate-specific transporter activity	1.95102182117705	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	1.86091881396874	bayes_pls_golite062009
ion transmembrane transporter activity	1.79083094640891	bayes_pls_golite062009
cation transmembrane transporter activity	1.72792205593593	bayes_pls_golite062009
drug transmembrane transporter activity	1.51403675564591	bayes_pls_golite062009
	1.44001556200678	bayes_pls_golite062009
metal ion transmembrane transporter activity	1.1603277826799	bayes_pls_golite062009
	1.01602145525561	bayes_pls_golite062009
active transmembrane transporter activity	0.769769685601419	bayes_pls_golite062009
efflux transmembrane transporter activity	0.21543973486818	bayes_pls_golite062009
antiporter activity	0.0217133902283497	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: