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Protein Overview: GPB2

General Information:
Name(s) found: GPB2 / YAL056W [SGD]
Description(s) found:
Found 18 descriptions.
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  • Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; homolog of Gpb1p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 880 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed article]
    plasma membrane [IDALink to PubMed article]
    Biological Process: ascospore formation [IMPLink to PubMed article]
    filamentous growth [IGILink to PubMed article]
    negative regulation of Ras protein signal transduction [IGILink to PubMed article]
    signal transduction [IPILink to PubMed article]
    telomere maintenance [IMPLink to PubMed article]
    invasive growth in response to glucose limitation [IGILink to PubMed article]
    positive regulation of transcription from RNA polymerase II promoter [IMPLink to PubMed article]
    negative regulation of phosphorylation [IGILink to PubMed article]
    Molecular Function: GTPase activating protein binding [IPILink to PubMed article]
    protein kinase inhibitor activity [IGILink to PubMed article]
    signal transducer activity [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEISSSPWND GGYSPYERNR VAVSPFSSAL EGEERIETSR SLGDHCFEPL PYVTNYLSIF  60
   61 ALFGKEIFGD KGNVSSRNEY LLKKYYSLKK PFVLRHNGHA LKNPDMPLQR NDILQTNFMV 120
  121 DKFLNRTVRS VNFNNFKIIS DMQSKSGRGT KSGTNQNQSA DAIQNICLPS IPSALPYFQY 180
  181 YRKLLTVNTK EWDILKLHSL WVPKLRKDFK DFSLYGDKNS LKPIDSHYDE DNTMKKNLFF 240
  241 ERSPSRQTLD GKGCASKGYD ISSGNMIIPS LFSEDKLPAL TYHCSVELNG NIYIFGGLMP 300
  301 CYSYEEDAPM LNDFFVDGIK NLPPPLLPQV INNPSMVNNP HLYVASIPSC RFSKPKMGGY 360
  361 IPPPLLCVQG SKLTDRHIFF YGGFEIRTET RGDENGKYHL KKRLYVNNTG YILDIMSFKF 420
  421 TKIDIIVQPS KYNAYPTMSS RFGHLQISID NPNRRASVHS SSMNEIHKMG SASMKQGSSI 480
  481 TSGRLEKAAV LSSLPHNTVH TVIIFGGYRQ TGDDRYEAMN DLWKIEIPVI RRGKKGYCKF 540
  541 SETANAILLT PSEKDKSDWP EERAFSAFSV HGTSLMDRSS LDMRLLNNLK NHFVLKPSYI 600
  601 SQDRVVSPKP VFPMMVHGTH QDLFNSGSAA QESPKAGASA SSASAASFDP DMDDNLENYI 660
  661 INPGRKSSSI PMTAIGRQRL ILSQEKPVGK TVVLHGGSNG LNVLDDMWLM DLECETWTPI 720
  721 ETFAKADSSE DGDEKLDSVN VGLVGHRMES IGRICVCIGG MVQEDVDQFY SENDDEPPRK 780
  781 RKVDTLPLGG NFLNTIDLST QFWEEHKITL SKKAADEDRQ DSENEDTNSN IVVGVGGTSL 840
  841 QCDKSIILIG GLISRRSNVK EIYLHGTITK SIFPSVNPSA

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) GPB1 GPB2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2 Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data GPB2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..171] deduced N/A No confident structure predictions are available.
    2 View Details [172..263] deduced N/A No confident structure predictions are available.
    3 View Details [264..435] MSA 1.005949 View MSA. No confident structure predictions are available.
    4 View Details [436..671] deduced N/A No confident structure predictions are available.
    5 View Details [672..880] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle