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Protein Overview: unc-38

General Information:
Name(s) found: unc-38 / CE24908 [WormBase]
Description(s) found:
Found 24 descriptions.
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  • WBGene00006774 locus:unc-38 Acetylcholine receptor subunit alpha-type unc-38 status:Confirmed UniProt:Q23022 protein_id:CCD69819.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 511 amino acids

    Gene Ontology:
    Cellular Component: postsynaptic membrane [IDALink to PubMed article][IEALink to PubMed article]
    membrane [IEALink to PubMed article]
    integral to membrane [IEALink to PubMed article]
    synapse [IDALink to PubMed article]
    neuron projection [IDALink to PubMed article]
    Biological Process: ion transport [IDALink to PubMed articleLink to PubMed article][IEALink to PubMed article]
    neuromuscular synaptic transmission [IDALink to PubMed article]
    locomotion [IMPLink to PubMed article]
    oviposition [IMPLink to PubMed article]
    transport [IEALink to PubMed article]
    Molecular Function: acetylcholine receptor activity [IDALink to PubMed articleLink to PubMed articleLink to PubMed article]
    neurotransmitter receptor activity [IEALink to PubMed article]
    extracellular ligand-gated ion channel activity [IDALink to PubMed articleLink to PubMed article][IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRSFWLFLLL LLFCISFIKL TEGNEDAKRL YDDLMVNYNR HRRPSTSPNK PLTIKLKLRL  60
   61 SQIIDVHEID QIMTCSVWLK QTWIDRKLSW DPVNYGGVNV LYVPYEMIWV PDIVLYNNAD 120
  121 SNYNITISTK ATLHYTGEVT WEPPAIFKSM CQIDVRWFPF DEQQCHLKFG SWTFSENLLS 180
  181 VELNEPSLRY EEEIDEKGII DNVTVAEDGI DLSDYYPSVE WDIMSRVAKR RAKNYPSCCP 240
  241 QSAYIDVTYY LQLRRKPLFY TVNLVFPCVG ISFLTILVFY LPSDSGEKVT LCISILVALT 300
  301 IFFLLLTEII PATSITLPLI GKYLLFTMVM VTLSVVVTVI SLNLHFRTPT THLMPNWVKK 360
  361 VFLKWLPKLL FMRRPIDDYE EKFDDKKKPK DGKIALSVHA HRVSNVGNNI RNATIDDTIQ 420
  421 KMYYSPPVVK AFENICFIAE LLKKKDRDDK IDEDWKYVAM VLDRLFLLIF SIACFVGTVI 480
  481 ILLRAPTLYD TRQPIDLQYR PANLSANPIS F

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..376] PSI-BLAST 76.221849 Refined structure of the nicotinic acetylcholine receptor at 4A resolution.
    2 View Details [377..511] PSI-BLAST 39.522879 Acetylcholine receptor protein, beta chain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • acetylcholine binding
    		•  13.9752632471881 bayes_pls_golite062009
  • acetylcholine receptor activity
    		•  13.7533645836795 bayes_pls_golite062009
  • nicotinic acetylcholine-activated cation-selective channel activity
    		•  13.1511875247796 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  11.9525876011069 bayes_pls_golite062009
  • extracellular ligand-gated ion channel activity
    		•  11.7813202122163 bayes_pls_golite062009
  • excitatory extracellular ligand-gated ion channel activity
    		•  11.7813202122163 bayes_pls_golite062009
  • cation channel activity
    		•  11.7442066737514 bayes_pls_golite062009
  • ion channel activity
    		•  11.1753684044644 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  11.0903806681397 bayes_pls_golite062009
  • channel activity
    		•  11.0903806681397 bayes_pls_golite062009
  • gated channel activity
    		•  11.0397691626728 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  10.9375522860542 bayes_pls_golite062009
  • ligand-gated channel activity
    		•  9.34902726749692 bayes_pls_golite062009
  • ligand-gated ion channel activity
    		•  9.34902726749692 bayes_pls_golite062009
  • amine binding
    		•  9.11982124959723 bayes_pls_golite062009
  • chloride channel regulator activity
    		•  9.10587892909341 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  7.22265353460749 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  7.19173677417054 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  6.7875346065164 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  5.4080353535498 bayes_pls_golite062009
  • receptor activity
    		•  5.11329651194787 bayes_pls_golite062009
  • transporter activity
    		•  5.11262082564788 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  5.03439798256257 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  4.91314874981447 bayes_pls_golite062009
  • neurotransmitter binding
    		•  4.25797760547212 bayes_pls_golite062009
  • neurotransmitter receptor activity
    		•  4.15404686068319 bayes_pls_golite062009
  • signal transducer activity
    		•  4.12549692767753 bayes_pls_golite062009
  • molecular transducer activity
    		•  4.12549692767753 bayes_pls_golite062009
  • adenylate cyclase binding
    		•  3.30190657223613 bayes_pls_golite062009
  • binding
    		•  2.4916526322278 bayes_pls_golite062009
  • beta-amyloid binding
    		•  2.25766805801029 bayes_pls_golite062009
    		• 1.68370717591127 bayes_pls_golite062009
  • channel regulator activity
    		•  1.66978990310631 bayes_pls_golite062009
  • protein binding
    		•  1.45740893920165 bayes_pls_golite062009
  • G-protein coupled receptor activity
    		•  1.42422063123689 bayes_pls_golite062009
  • serotonin binding
    		•  1.33584589886834 bayes_pls_golite062009
  • serotonin-activated cation-selective channel activity
    		•  1.31324203158511 bayes_pls_golite062009
  • toxin binding
    		•  1.03329843925063 bayes_pls_golite062009
  • drug binding
    		•  0.64715018605883 bayes_pls_golite062009
  • kinase binding
    		•  0.365355763029699 bayes_pls_golite062009
  • protein kinase binding
    		•  0.350601457777817 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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