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Protein Overview: trf1

General Information:
Name(s) found: trf1 / SPBC19G7.13 [Sanger Pombe]
Description(s) found:
Found 20 descriptions.
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  • telomeric DNA binding factor Trf1 [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 485 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed articleLink to PubMed article]
    chromosome, telomeric region [IEA]
    nuclear chromatin [IDALink to PubMed article]
    integral to membrane [IEA]
    Biological Process: cell cycle arrest [IMPLink to PubMed article]
    telomere maintenance [IMPLink to PubMed article]
    telomere maintenance via telomerase [IEA]
    regulation of transcription from RNA polymerase II promoter [IMPLink to PubMed article]
    Molecular Function: transcription regulator activity [IMPLink to PubMed article]
    double-stranded telomeric DNA binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKRSLDPSD DFKGQKRLAI DPESTALEQD RQMLQQLSEQ NSELEPQNVA PNAEIPLGFD  60
   61 LSGIQFNMTP DFYLRMNQGM DYAFNQPNPI ATPQQLLRTS LIPTLGNLSN IILSILGKPV 120
  121 QEASAIVTNP ASEMGMAFTK VMNMFRMVKD IYTEESFIYS SAIGMRTPSQ RSTTRRANLA 180
  181 IFLAAVYGAL QIGFFHLNEN FLEVFAPDES NILTNQGTLY MELKTQAYIS AMAQAERPKG 240
  241 DILNDLFPSD MAHRFLIRRN AKLDDKLTYV EKQIIEKCTA RKERLANFSP QEALNEVYPW 300
  301 GKFLSEIACY IHNNYSSISA IPIPANSFKR RSKKNGLRFK AGEAESSPSE SGSDLTDSLA 360
  361 FGIPSSTFDG SSETQNVSSV VLYDQVRHMT NNNLNNKRTR RVANRRSWTK EEEEALLDGL 420
  421 DLVKGPRWSQ ILELYGPGGK KSEVLKYRNQ VQLKDKARNM KLFFLKSGQV VPAALQCVTG 480
  481 DLRRD

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..300] deduced N/A No confident structure predictions are available.
    2 View Details [301..381] deduced N/A No confident structure predictions are available.
    3 View Details [382..485] PSI-BLAST 6.69897 DNA-binding domain of human telomeric protein, hTRF1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • transcription regulator activity
    		•  5.13863038737912 bayes_pls_golite062009
  • DNA binding
    		•  4.66369707598026 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.51452285155271 bayes_pls_golite062009
  • transcription factor activity
    		•  4.06706589695599 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.16896789933192 bayes_pls_golite062009
  • binding
    		•  3.02779747447702 bayes_pls_golite062009
  • telomeric DNA binding
    		•  2.54876676195978 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.41271657675151 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.91962622287073 bayes_pls_golite062009
  • transcription activator activity
    		•  1.77700860354597 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.73068440195944 bayes_pls_golite062009
  • chromatin binding
    		•  1.68956710349366 bayes_pls_golite062009
  • transcription factor binding
    		•  1.40653841901929 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.84983974758882 bayes_pls_golite062009
  • protein binding
    		•  0.830419844171551 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.666799964992178 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.529774583092406 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.25931464844298 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.236060274498333 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.187022204923867 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.105174598157041 bayes_pls_golite062009
  • histone binding
    		•  0.0391625783266718 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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