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Protein Overview: lig4

General Information:
Name(s) found: lig4 / SPCC1183.05c [Sanger Pombe]
Description(s) found:
Found 17 descriptions.
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  • DNA ligase Lig4 [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 923 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ISSLink to PubMed article]
    DNA ligase IV complex [TASLink to PubMed article]
    Biological Process: DNA replication [IEA]
    DNA recombination [IEA]
    double-strand break repair via nonhomologous end joining [IMPLink to PubMed article]
    Molecular Function: magnesium ion binding [IEA]
    ATP binding [ICLink to PubMed article]
    DNA binding [IEA]
    DNA ligase (ATP) activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDEAKETVFT KPQNHSSTLE FYDFVTTLLE PLSRIGKTRK SKTSNLDPYE LKRKILLDYF  60
   61 NKWRQHVGPD LYPLLRLSNL IFLDRERGSY GFKEFGLGKL FIRAMHLSPT SEDAKSLKNW 120
  121 RGSESKHTGD FSTMLQDILQ RRAYRTFPGA FTVGDVNALL DQLADASSEY VLNFLPYLTL 180
  181 IRDTRVNILE QFYRSLSPLE LRWLIPILLK VRKYGTSEKF ILSVFHPDAA RLYRLCSSLK 240
  241 RICWELYDPS RSLDETETDV EVFSCFQPQL ANFKKKDLHQ TLEAMGNKPF WIEEKLDGER 300
  301 IQLHMSSGKF QFYSRNARSY TYAYGSSYFD EQSRLTQYII GAFDKRISQI ILDGEMVTWD 360
  361 PVLETVIPYG SLRSIFEDSS SHSSYSPYYV VFDILYLNGK SLVKYSLESR RRILEKVIVR 420
  421 ESHRMSILPY KVGSTIEDIE AELRNVIQEG SEGLVIKKPS GSYHLGERMD DWIKVKPYYL 480
  481 QGFGEDLDCL ILGGYFGRGK QSGKINSFLC GLRMDYTPKD HSEKFQSFVR VGGGFTYFDR 540
  541 DIIRKETEGK WLPWSSDALE YMELAGTKQD FEKPDMWIHP KDSLVLQIKA AEVVVSNRFK 600
  601 TNYTLRFPRL EKVRLDRSWK DALTINEFFT LKNAVEKQDN VSFHVNKKRK VSQKREKQKK 660
  661 FLYDEPTFKK EASPHSDVLK NLHFVVLPPT ELHETKAGLQ QIIIENGGLI HQGVGNFGKE 720
  721 RLFLVADRVS TRVSIERSKN MCTIIRSQWV MDSVNNQRLM PQWSYLLFSK DEKYSWKTAL 780
  781 ESLSAKSLSN LLVELKQLDL SKEYSKISDD TSILNLTISK EEASFVGAFP FLKFTVFLDL 840
  841 KGIENSELYD VRMGQYRLTK CILLWNGATI EKDISSKKLT HVVMFVEDST RLEQLTKACE 900
  901 LTQHRKFTQP SYFQRYGGSF CIP

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..648] PSI-BLAST 136.0 Crystal Structure of Human DNA Ligase I bound to 5'-adenylated, nicked DNA
    2 View Details [649..826] PSI-BLAST 18.522879 Co-Crystal Structure of Lif1p-Lig4p
    3 View Details [827..923] PSI-BLAST 17.154902 The third BRCA1 C-terminus (BRCT) domain of Similar to S.pombe rad4+/cut5+ product

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • DNA ligase activity
    		•  10.0279903057926 bayes_pls_golite062009
  • ligase activity, forming phosphoric ester bonds
    		•  9.92846900587219 bayes_pls_golite062009
  • DNA ligase (ATP) activity
    		•  8.51283882444113 bayes_pls_golite062009
  • DNA ligase (NAD+) activity
    		•  3.1488483282989 bayes_pls_golite062009
  • ligase activity
    		•  2.44151794329612 bayes_pls_golite062009
  • catalytic activity
    		•  2.15370807854636 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.4725380374617 bayes_pls_golite062009
  • binding
    		•  1.23714137231717 bayes_pls_golite062009
  • DNA binding
    		•  1.1855473374207 bayes_pls_golite062009
  • protein binding
    		•  0.352542259246499 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  0.316166307022498 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle