Abstract
The accurate repair of DNA double-strand breaks is essential for cell survival and maintenance of genome integrity. Here we describe xlf1+, a gene in the fission yeast Schizosaccharomyces pombe that is required for repair of double-strand breaks by nonhomologous end joining during G1 phase of the cell cycle. Xlf1 is the ortholog of budding yeast Nej1 and human XLF/Cernunnos proteins.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Amino Acid Sequence
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DNA Repair / genetics*
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G1 Phase
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Molecular Sequence Data
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Recombination, Genetic*
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Schizosaccharomyces / genetics*
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Schizosaccharomyces pombe Proteins / chemistry
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Schizosaccharomyces pombe Proteins / genetics*
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Sequence Homology
Substances
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Schizosaccharomyces pombe Proteins
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XLF1 protein, S pombe