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Protein Overview: erg5

General Information:
Name(s) found: erg5 / SPAC19A8.04 [Sanger Pombe]
Description(s) found:
Found 17 descriptions.
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  • C-22 sterol desaturase Erg5 [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 541 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum [ISSLink to PubMed article]
    Biological Process: establishment of protein localization in plasma membrane [IMPLink to PubMed article]
    protein insertion into membrane raft [IMPLink to PubMed article]
    ergosterol biosynthetic process [IEPLink to PubMed article][IMPLink to PubMed article]
    [NOT]endocytosis [IMPLink to PubMed article]
    [NOT]protein targeting to vacuole [IMPLink to PubMed article]
    Molecular Function: protein binding [IPILink to PubMed article]
    iron ion binding [IEA]
    C-22 sterol desaturase activity [ISSLink to PubMed article]
    monooxygenase activity [IEA]
    heme binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNQTETLIPA ARNVIRVLGY EIEYSKWTIC FALLAVCIAY DQISYQMQKG HIPGPRFKIP  60
   61 FMGSFLDSMK PTFEKYNAKW QTGPLSCVSV FHKFVVIASE RDLARKILNS PSYVQPCVVD 120
  121 AGKKILKHTN WVFLDGRDHI EYRKGLNGLF TTRALASYLP AQEAVYNKYF KEFLAHSKDD 180
  181 YAQYMIPFRD INVATSCRTF CGYYISDDAI KHIADEYWKI TAAMELVNFP IVLPFTKVWY 240
  241 GIQSRKVVMR YFMKAAAESR KNMEAGNAPA CMMEEWIHEM IETRKYKSEN KEGAEKPSVL 300
  301 IREFSDEEIS LTFLSFLFAS QDATSSAMTW LFQLLADHPD VLQKVREEQL RIRKGDIDVP 360
  361 LSLDLMEKMT YTRAVVKECL RLRPPVLMVP YRVKKAFPIT PDYTVPKDAM VIPTLYGALH 420
  421 DSKVYPEPET FNPDRWAPNG LAEQSPKNWM VFGNGPHVCL GQRYAVNHLI ACIGKASIML 480
  481 DWKHKRTPDS DTQMIFATTF PQDMCYLKFS PFDASTVDWK NSKEAFSNEA VSAATVETES 540
  541 A

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run spc19 No Comments Liu X, et al. (2005)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..541] PSI-BLAST 100.0 Crystal Structure of Human Drug Metabolizing Cytochrome P450 2C8

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • arachidonic acid monooxygenase activity
    		•  6.76823710927794 bayes_pls_golite062009
  • monooxygenase activity
    		•  5.57229509004705 bayes_pls_golite062009
  • steroid hydroxylase activity
    		•  5.04794778387361 bayes_pls_golite062009
  • arachidonic acid epoxygenase activity
    		•  4.80764258881036 bayes_pls_golite062009
  • steroid 17-alpha-monooxygenase activity
    		•  3.99744233006162 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
    		•  3.68151610133025 bayes_pls_golite062009
  • demethylase activity
    		•  3.40807632433846 bayes_pls_golite062009
  • sterol 14-demethylase activity
    		•  2.94610675710811 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
    		•  2.41884363121524 bayes_pls_golite062009
  • oxysterol 7-alpha-hydroxylase activity
    		•  2.36480328243514 bayes_pls_golite062009
  • oxidoreductase activity
    		•  2.35847923992364 bayes_pls_golite062009
  • retinoic acid 4-hydroxylase activity
    		•  2.27465774301343 bayes_pls_golite062009
  • oxygen binding
    		•  2.16126306603565 bayes_pls_golite062009
  • fatty acid (omega-1)-hydroxylase activity
    		•  1.65569090470706 bayes_pls_golite062009
  • corticosterone 18-monooxygenase activity
    		•  1.64204907906991 bayes_pls_golite062009
  • steroid 11-beta-monooxygenase activity
    		•  1.64204907906991 bayes_pls_golite062009
  • retinoid binding
    		•  1.55427837836259 bayes_pls_golite062009
  • electron carrier activity
    		•  1.48516712188486 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
    		•  1.46109575978397 bayes_pls_golite062009
  • isoprenoid binding
    		•  1.43053384013166 bayes_pls_golite062009
  • binding
    		•  1.2866152532988 bayes_pls_golite062009
  • retinoic acid binding
    		•  1.21667685596765 bayes_pls_golite062009
  • catalytic activity
    		•  0.608111453189583 bayes_pls_golite062009
  • cholesterol monooxygenase (side-chain-cleaving) activity
    		•  0.276594551871869 bayes_pls_golite062009
  • steroid 7-alpha-hydroxylase activity
    		•  0.201977555505571 bayes_pls_golite062009
  • arachidonic acid 11,12-epoxygenase activity
    		•  0.0888154993183798 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.81

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle