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Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2. Catalysis of the reaction: cholesterol + reduced adrenal ferredoxin + O2 = pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin + H2O. Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced iron-sulfur protein and one other donor, and one atom of oxygen is incorporated into one donor. Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: cholesterol monooxygenase (side-chain-cleaving) activity
Acc: GO:0008386
Aspect: Molecular Function
Desc: Catalysis of the reaction: cholesterol + reduced adrenal ferredoxin + O2 = pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin + H2O.
Synonyms:
  • cholesterol,reduced-adrenal-ferredoxin:oxygen oxidoreductase (side-chain-cleaving)
  • cytochrome p450(scc) activity
  • cytochrome P-450(scc) activity
  • cholesterol 20-22-desmolase activity
  • cytochrome p450scc
  • cytochrome P-450scc
  • enzymes, cholesterol side-chain-cleaving
  • cholesterol C20-22 desmolase activity
  • cholesterol side-chain cleavage enzyme activity
  • cholesterol C(20-22) desmolase activity
  • desmolase, steroid 20-22
  • C27-side chain cleavage enzyme
  • cholesterol side-chain-cleaving enzyme activity
  • Cyp11a1
  • steroid 20-22 desmolase activity
  • cholesterol desmolase activity
  • steroid 20-22-lyase activity
Proteins in PDR annotated with:
   This term: 4 [Search]
   Term or descendants: 4 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0008386 - cholesterol monooxygenase (side-chain-cleaving) activity (interactive image map)
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Created and Maintained by: Michael Riffle