YRC Public Data Repository - Protein Structure Prediction

Protein:	erg5
Organism:	Schizosaccharomyces pombe
Length:	541 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for erg5.

Description	E-value	Query Range	Subject Range
CP2CK_MACFA - Cytochrome P450 2C20 OS=Macaca fascicularis GN=CYP2C20 PE=2 SV=1	374.0	[0..26]	[511..3]
CYP2C8 - cytochrome P450, family 2, subfamily C, polypeptide 8	374.0	[0..26]	[511..3]
gi\|115496944, gi... - gi\|94574282\|gb\|AAI16042.1\| Cytochrome P450, family 2, subfamily C, polypeptide 18 [Bos taurus], gi\|1...	374.0	[0..43]	[511..20]
gi\|66731521 - gi\|66731521\|gb\|AAY51973.1\| cytochrome P450 2C8 [Cercopithecus aethiops]	373.0	[0..26]	[511..3]
gi\|94158944, gi\|... - gi\|94158944\|ref\|NP_001035300.1\| cytochrome P450, family 2, subfamily C, polypeptide 8 [Macaca mulatt...	372.0	[0..26]	[511..3]
gi\|114631924 - gi\|114631924\|ref\|XP_001153207.1\| PREDICTED: similar to Cytochrome P450 2C8 (CYPIIC8) (P450 form 1) (...	371.0	[0..26]	[511..3]
gi\|116174726, gi... - gi\|55824550\|gb\|AAV66395.1\| cytochrome P450 isoform 2J [Ovis aries], gi\|116174726\|ref\|NP_001070678.1\|...	370.0	[0..10]	[512..1]

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Predicted Domain #1

Region A:
Residues: [1-541]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNQTETLIPA ARNVIRVLGY EIEYSKWTIC FALLAVCIAY DQISYQMQKG HIPGPRFKIP  60
   61 FMGSFLDSMK PTFEKYNAKW QTGPLSCVSV FHKFVVIASE RDLARKILNS PSYVQPCVVD 120
  121 AGKKILKHTN WVFLDGRDHI EYRKGLNGLF TTRALASYLP AQEAVYNKYF KEFLAHSKDD 180
  181 YAQYMIPFRD INVATSCRTF CGYYISDDAI KHIADEYWKI TAAMELVNFP IVLPFTKVWY 240
  241 GIQSRKVVMR YFMKAAAESR KNMEAGNAPA CMMEEWIHEM IETRKYKSEN KEGAEKPSVL 300
  301 IREFSDEEIS LTFLSFLFAS QDATSSAMTW LFQLLADHPD VLQKVREEQL RIRKGDIDVP 360
  361 LSLDLMEKMT YTRAVVKECL RLRPPVLMVP YRVKKAFPIT PDYTVPKDAM VIPTLYGALH 420
  421 DSKVYPEPET FNPDRWAPNG LAEQSPKNWM VFGNGPHVCL GQRYAVNHLI ACIGKASIML 480
  481 DWKHKRTPDS DTQMIFATTF PQDMCYLKFS PFDASTVDWK NSKEAFSNEA VSAATVETES 540
  541 A

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	100.0
Match:	1pq2A
Description:	Crystal Structure of Human Drug Metabolizing Cytochrome P450 2C8
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
arachidonic acid monooxygenase activity	6.76823710927794	bayes_pls_golite062009
monooxygenase activity	5.57229509004705	bayes_pls_golite062009
steroid hydroxylase activity	5.04794778387361	bayes_pls_golite062009
arachidonic acid epoxygenase activity	4.80764258881036	bayes_pls_golite062009
steroid 17-alpha-monooxygenase activity	3.99744233006162	bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3.68151610133025	bayes_pls_golite062009
demethylase activity	3.40807632433846	bayes_pls_golite062009
sterol 14-demethylase activity	2.94610675710811	bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	2.41884363121524	bayes_pls_golite062009
oxysterol 7-alpha-hydroxylase activity	2.36480328243514	bayes_pls_golite062009
oxidoreductase activity	2.35847923992364	bayes_pls_golite062009
retinoic acid 4-hydroxylase activity	2.27465774301343	bayes_pls_golite062009
oxygen binding	2.16126306603565	bayes_pls_golite062009
fatty acid (omega-1)-hydroxylase activity	1.65569090470706	bayes_pls_golite062009
corticosterone 18-monooxygenase activity	1.64204907906991	bayes_pls_golite062009
steroid 11-beta-monooxygenase activity	1.64204907906991	bayes_pls_golite062009
retinoid binding	1.55427837836259	bayes_pls_golite062009
electron carrier activity	1.48516712188486	bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	1.46109575978397	bayes_pls_golite062009
isoprenoid binding	1.43053384013166	bayes_pls_golite062009
binding	1.2866152532988	bayes_pls_golite062009
retinoic acid binding	1.21667685596765	bayes_pls_golite062009
catalytic activity	0.608111453189583	bayes_pls_golite062009
cholesterol monooxygenase (side-chain-cleaving) activity	0.276594551871869	bayes_pls_golite062009
steroid 7-alpha-hydroxylase activity	0.201977555505571	bayes_pls_golite062009
arachidonic acid 11,12-epoxygenase activity	0.0888154993183798	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: