Protein Overview: SPBC1703.07

General Information:
Name(s) found:	SPBC1703.07 [Sanger Pombe]
Description(s) found: Found 19 descriptions. SHOW ALL	ATP citrate synthase subunit 1 [Sanger Pombe]
Organism:	Schizosaccharomyces pombe
Length:	615 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA] cytoplasm [ISS] cytosol [IDA]
Biological Process:	cellular carbohydrate metabolic process [IEA] acetyl-CoA biosynthetic process [ISS] citrate metabolic process [IC] tricarboxylic acid cycle [IC] fatty acid biosynthetic process [ISS]
Molecular Function:	magnesium ion binding [IEA] ATP binding [IEA] ATP citrate synthase activity [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAGSVDKPSY ELFSKDTRAF VYGMQTKAVQ GMLDFDYMCG RTVPSVAAII YTFGSQSISK  60
   61 LYWGTKEILL PVYRTIEEAC TKHPEVDVVV NFASSRSAYA STMELMEFPQ IRCIAIIAEG 120
  121 VPERRAREIL VTSKEKNVVI IGPATVGGIK PGCFKIGNTG GMMDNIVASK LYRPGSVAYV 180
  181 SKSGGMSNEL NNIISHTTDG VYEGIAIGGD RYPGTTFIDH LIRFEADPAC KLMVLLGEVG 240
  241 GVEEYRVIEA VKNGTIKKPI VAWAIGTCSS MFKTEVQFGH AGSFANSELE TAVAKNQAMR 300
  301 EAGIYVPETF EKLPALLQEV YEGLVKKGVI VPQPEVAPPN IPLDYAWAKE LGLVRKPSSF 360
  361 ICTISNDRGS ELTYNNVPIS KVFEEELGIG GVISLLWLRR RLPSYATKFL EMVLQLTADH 420
  421 GPCVSGAMNT IITTRAGKDL ISSLVAGLLT IGTRFGGALD GAAQEFSKAY DAGLSPRAFV 480
  481 DSCRKANKLI PGIGHRIKSR NNPDLRVELV KGYVKKNFPS TKLLDYALAV ENVTTSKKDN 540
  541 LILNVDGCIA VCFVDLLRNC GAFTLEEANE YINLGILNGM FVLGRSIGLI GHHLDQKRLR 600
  601 APLYRHPWDD FLYLS

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..229]	PSI-BLAST	87.154902	Succinyl-CoA synthetase, alpha-chain, N-terminal (CoA-binding) domain; Succinyl-CoA synthetase, alpha-chain, C-terminal domain
2	View Details	[230..615]	PSI-BLAST	65.522879	CRYSTALLOGRAPHIC REFINEMENT AND ATOMIC MODELS OF TWO DIFFERENT FORMS OF CITRATE SYNTHASE AT 2.7 AND 1.7 ANGSTROMS RESOLUTION

Functions predicted (by domain):

#

Gene Ontology predictions

1

Term	Confidence	Notes
succinate-CoA ligase activity	4.98013776954984	bayes_pls_golite062009
CoA-ligase activity	4.35815624912718	bayes_pls_golite062009
acid-thiol ligase activity	4.2282982893826	bayes_pls_golite062009
ligase activity, forming carbon-sulfur bonds	3.82878743369312	bayes_pls_golite062009
succinate-CoA ligase (ADP-forming) activity	3.05087440872447	bayes_pls_golite062009
catalytic activity	1.79741889688267	bayes_pls_golite062009
fatty acid synthase activity	1.23679054027553	bayes_pls_golite062009
oxidoreductase activity	0.9367410227151	bayes_pls_golite062009
3-oxoacyl-[acyl-carrier-protein] reductase activity	0.604742541607263	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	0.602741520623622	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	0.418775403210681	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	0.32207755075663	bayes_pls_golite062009
nucleic acid binding	0.100470710829263	bayes_pls_golite062009
DNA binding	0.0870043837215047	bayes_pls_golite062009
alcohol dehydrogenase (NAD) activity	0.00644214957417527	bayes_pls_golite062009

2

Term	Confidence	Notes
citrate (Si)-synthase activity	5.74736490002685	bayes_pls_golite062009
transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer	5.63245943049967	bayes_pls_golite062009
transferase activity, transferring acyl groups	2.88522337475651	bayes_pls_golite062009
catalytic activity	2.51855037019879	bayes_pls_golite062009
transferase activity	2.22659761972612	bayes_pls_golite062009

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.81

Source: Reynolds et al. (2008)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle