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Protein Overview: alpha-Man-I-PK, ...

General Information:
Name(s) found: FBpp0304147 [FlyBase]
alpha-Man-I-PK / FBpp0289739 [FlyBase]
Description(s) found:
Found 27 descriptions.
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  • type=protein; loc=X:complement(10171589..10171735,10171794..10172055,10172125..10172263,10172326..10172550,10172612..10173224,10180482..10181027); ID=FBpp0304147; name=alpha-Man-I-PP; parent=FBgn0259170,FBtr0331759; dbxref=REFSEQ:NP_001259402,GB_protein:AGB95245,FlyBase:FBpp0304147,FlyBase_Annotation_IDs:CG42275-PP; MD5=697dfd3f2d398583927688388a999cbf; length=643; release=r5.56; species=Dmel; [FlyBase]
  • The gene Ã?&#142;Ã?± Mannosidase I is referred to in FlyBase by the symbol Dmel\Ã?&#142;Ã?±-Man-I (CG42275, FBgn0259170). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:10170088..10219990. It has the cytological map location 9B6. Based on sequence similarity, it is predicted to have molecular function</span>: mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. There is experimental evidence that it is involved in the biological process</span>: determination of adult lifespan. 38 alleles are reported. The phenotypes of these alleles are annotated with: interommatidial bristle; peripheral nervous system; ommatidium. It has 8 annotated transcripts and 8 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 643 amino acids

    Gene Ontology:
    Cellular Component: membrane [IEA]
    Golgi apparatus [ISS]
    Golgi membrane [NAS]
    Biological Process: determination of adult lifespan [IMP]
    protein amino acid N-linked glycosylation [ISS][NAS]
    Molecular Function: calcium ion binding [IEA]
    mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MCPKTSKTTP LLLIGGICFV IVLVGITGIT LINNINLSNI IRLNEKVASD SVSNNENQIK  60
   61 ELNYVNNHPR NVYLKLNASS RDDEDDEQMQ KEQEQLELPK ISAVIGGSKP KVEDNQVKES 120
  121 SEVISPSTST FSMRSSAGEL TSTSAPLSSI VSVTAPPMPF GGVKYNQSSG LIDYEKRNQV 180
  181 VKMMEHAWHN YKLYAWGKNE LRPLSQRPHS ASIFGSYDLG ATIVDGLDTL YIMGLEKEYR 240
  241 EGRDWIERKF SLDNISAELS VFETNIRFVG GMLTLYAFTG DPLYKEKAQH VADKLLPAFQ 300
  301 TPTGIPYALV NTKTGVAKNY GWASGGSSIL SEFGTLHLEF AYLSDITGNP LYRERVQTIR 360
  361 QVLKEIEKPK GLYPNFLNPK TGKWGQLHMS LGALGDSYYE YLLKAWLQSG QTDEEAREMF 420
  421 DEAMLAILDK MVRTSPGGLT YVSDLKFDRL EHKMDHLACF SGGLFALGAA TRQNDYTDKY 480
  481 MEVGKGITNT CHESYIRAPT QLGPEAFRFS EAVEARALRS QEKYYILRPE TFESYFVLWR 540
  541 LTHDQKYRDW GWEAVLALEK HCRTAHGYCG LRNVYQQEPQ KDDVQQSFFL AETLKYLYLL 600
  601 FSDDSVLPLD EWVFNTEAHP LPIKGANAYY RQAPVTLPVS NAS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..125] MSA 3.143997 View MSA. No confident structure predictions are available.
    2 View Details [126..643] PSI-BLAST 180.0 Structure of mouse Golgi alpha-1,2-mannosidase IA reveals the molecular basis for substrate specificity among Class I enzymes (family 47 glycosidases)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • mannosyl-oligosaccharide mannosidase activity
    		•  7.089685350864 bayes_pls_golite062009
  • mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
    		•  6.95179264736435 bayes_pls_golite062009
  • mannosidase activity
    		•  5.20286438265852 bayes_pls_golite062009
  • hydrolase activity, hydrolyzing O-glycosyl compounds
    		•  4.31319275372149 bayes_pls_golite062009
  • hydrolase activity, acting on glycosyl bonds
    		•  3.65589746311782 bayes_pls_golite062009
  • hydrolase activity
    		•  2.67964748309919 bayes_pls_golite062009
  • binding
    		•  1.49199031708525 bayes_pls_golite062009
  • catalytic activity
    		•  1.31873306707813 bayes_pls_golite062009
  • cation binding
    		•  0.362242764130218 bayes_pls_golite062009
  • metal ion binding
    		•  0.362242764130218 bayes_pls_golite062009
  • protein binding
    		•  0.36081692928767 bayes_pls_golite062009
  • ion binding
    		•  0.355220167272296 bayes_pls_golite062009
  • calcium ion binding
    		•  0.121126738064555 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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