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Protein Overview: mof-PA

General Information:
Name(s) found: mof-PA / FBpp0070794 [FlyBase]
Description(s) found:
Found 27 descriptions.
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  • The gene males absent on the first is referred to in FlyBase by the symbol Dmel\mof (CG3025, FBgn0014340). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:5767868..5770884. It has the cytological map location 5C5. There is experimental evidence that it has the molecular function</span>: chromatin binding. There is experimental evidence that it is involved in the biological process</span>: dosage compensation. 33 alleles are reported. The phenotype of these alleles is annotated with: embryonic heart. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 827 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEA]
    X chromosome [TAS]
    chromatin [IEA]
    X chromosome located dosage compensation complex, transcription activating [NAS][TAS]
    Biological Process: dosage compensation [IGI][IMP][NAS][TAS]
    peptidyl-lysine acetylation [TAS]
    chromatin assembly or disassembly [IEA]
    histone acetylation [NAS][TAS]
    dosage compensation, by hyperactivation of X chromosome [NAS]
    regulation of transcription [IEA]
    Molecular Function: histone acetyltransferase activity [ISS][NAS][TAS]
    lysine N-acetyltransferase activity [TAS]
    protein binding [TAS]
    mRNA binding [TAS]
    histone acetyltransferase activity (H4-K16 specific) [TAS]
    chromatin binding [IDA][TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEAELEQTP SAGHVQEQPI EEEHEPEQEP TDAYTIGGPP RTPVEDAAAE LSASLDVSGS  60
   61 DQSAEQSLDL SGVQAEAAAE SEPPAKRQHR DISPISEDST PASSTSTSST RSSSSSRYDD 120
  121 VSEAEEAPPE PEPEQPQQQQ QEEKKEDGQD QVKSPGPVEL EAQEPAQPQK QKEVVDQEIE 180
  181 TEDEPSSDTV ICVADINPYG SGSNIDDFVM DPDAPPNAII TEVVTIPAPL HLKGTQQLGL 240
  241 PLAAPPPPPP PPAAEQVPET PASPTDDGEE PPAVYLSPYI RSRYMQESTP GLPTRLAPRD 300
  301 PRQRNMPPPA VVLPIQTVLS ANVEAISDDS SETSSSDDDE EEEEDEDDAL TMEHDNTSRE 360
  361 TVITTGDPLM QKIDISENPD KIYFIRREDG TVHRGQVLQS RTTENAAAPD EYYVHYVGLN 420
  421 RRLDGWVGRH RISDNADDLG GITVLPAPPL APDQPSTSRE MLAQQAAAAA AASSERQKRA 480
  481 ANKDYYLSYC ENSRYDYSDR KMTRYQKRRY DEINHVQKSH AELTATQAAL EKEHESITKI 540
  541 KYIDKLQFGN YEIDTWYFSP FPEEYGKART LYVCEYCLKY MRFRSSYAYH LHECDRRRPP 600
  601 GREIYRKGNI SIYEVNGKEE SLYCQLLCLM AKLFLDHKVL YFDMDPFLFY ILCETDKEGS 660
  661 HIVGYFSKEK KSLENYNVAC ILVLPPHQRK GFGKLLIAFS YELSRKEGVI GSPEKPLSDL 720
  721 GRLSYRSYWA YTLLELMKTR CAPEQITIKE LSEMSGITHD DIIYTLQSMK MIKYWKGQNV 780
  781 ICVTSKTIQD HLQLPQFKQP KLTIDTDYLV WSPQTAAAVV RAPGNSG

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..216] MSA 3.237995 View MSA. No confident structure predictions are available.
    2 View Details [217..359] MSA 1.244996 View MSA. No confident structure predictions are available.
    3 View Details [360..523] FFAS03 3.21 Solution Structure of the Tudor Domain from Mouse Hypothetical Protein Homologous to Histone Acetyltransferase
    4 View Details [524..827] PSI-BLAST 135.0 No description for 2givA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • transcription repressor activity
    		•  3.8081899455836 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.52013719299428 bayes_pls_golite062009
  • chromatin binding
    		•  3.40552458111422 bayes_pls_golite062009
  • methylated histone residue binding
    		•  3.0459266457552 bayes_pls_golite062009
  • binding
    		•  2.96155744225842 bayes_pls_golite062009
  • protein binding
    		•  2.55372006358699 bayes_pls_golite062009
  • transcription elongation regulator activity
    		•  2.33879979958688 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.19595603594923 bayes_pls_golite062009
  • DNA binding
    		•  2.0541708282373 bayes_pls_golite062009
  • histone binding
    		•  1.79126887796584 bayes_pls_golite062009
  • transcription activator activity
    		•  1.44969595924682 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.08214787027892 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.9574603809992 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.67878641652425 bayes_pls_golite062009
  • RNA binding
    		•  0.49455178642198 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  0.426548109966398 bayes_pls_golite062009
  • general transcriptional repressor activity
    		•  0.402515314009813 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.227441509754587 bayes_pls_golite062009
  • catalytic activity
    		•  0.168308115787289 bayes_pls_golite062009
    4
    Term Confidence Notes
  • N-acetyltransferase activity
    		•  10.330867741687 bayes_pls_golite062009
  • histone acetyltransferase activity
    		•  10.2385402730839 bayes_pls_golite062009
  • lysine N-acetyltransferase activity
    		•  10.2385402730839 bayes_pls_golite062009
  • N-acyltransferase activity
    		•  10.2097972775096 bayes_pls_golite062009
  • acetyltransferase activity
    		•  9.5414870492393 bayes_pls_golite062009
  • acyltransferase activity
    		•  8.84144467104026 bayes_pls_golite062009
  • transferase activity, transferring acyl groups other than amino-acyl groups
    		•  8.80032457938662 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  8.58458341779614 bayes_pls_golite062009
  • histone acetyltransferase activity (H4-K16 specific)
    		•  8.54452063525878 bayes_pls_golite062009
    		• 7.30820970670781 bayes_pls_golite062009
    		• 5.22897636875434 bayes_pls_golite062009
  • H3 histone acetyltransferase activity
    		•  3.57980162499154 bayes_pls_golite062009
  • transferase activity
    		•  2.87429355361226 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.24760844790231 bayes_pls_golite062009
  • transcription activator activity
    		•  2.22111981353244 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.13750665291344 bayes_pls_golite062009
  • catalytic activity
    		•  1.97933499002461 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.31507488567214 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.294475171667 bayes_pls_golite062009
  • binding
    		•  1.22537494136129 bayes_pls_golite062009
  • transcription coactivator activity
    		•  1.2180007740195 bayes_pls_golite062009
  • transcription factor binding
    		•  1.13174003342838 bayes_pls_golite062009
  • protein binding
    		•  1.12627968510377 bayes_pls_golite062009
  • myristoyltransferase activity
    		•  0.774009286200155 bayes_pls_golite062009
  • glycylpeptide N-tetradecanoyltransferase activity
    		•  0.774009286200155 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.605899196605446 bayes_pls_golite062009
  • histone binding
    		•  0.582104626133107 bayes_pls_golite062009
  • RNA binding
    		•  0.35120530780805 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.31196049232138 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle