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View Structure Prediction Details

Protein: mof-PA
Organism: Drosophila melanogaster
Length: 827 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for mof-PA.

Description E-value Query
Range
Subject
Range
gi|119615067 - gi|119615067|gb|EAW94661.1| MYST histone acetyltransferase 2, isoform CRA_d [Homo sapiens]
gi|149053929 - gi|149053929|gb|EDM05746.1| MYST histone acetyltransferase 2, isoform CRA_a [Rattus norvegicus]
gi|74188756 - gi|74188756|dbj|BAE28109.1| unnamed protein product [Mus musculus]
562.0 [0..369] [817..5]

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Predicted Domain #1
Region A:
Residues: [1-216]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEAELEQTP SAGHVQEQPI EEEHEPEQEP TDAYTIGGPP RTPVEDAAAE LSASLDVSGS  60
   61 DQSAEQSLDL SGVQAEAAAE SEPPAKRQHR DISPISEDST PASSTSTSST RSSSSSRYDD 120
  121 VSEAEEAPPE PEPEQPQQQQ QEEKKEDGQD QVKSPGPVEL EAQEPAQPQK QKEVVDQEIE 180
  181 TEDEPSSDTV ICVADINPYG SGSNIDDFVM DPDAPP

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [217-359]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NAIITEVVTI PAPLHLKGTQ QLGLPLAAPP PPPPPPAAEQ VPETPASPTD DGEEPPAVYL  60
   61 SPYIRSRYMQ ESTPGLPTRL APRDPRQRNM PPPAVVLPIQ TVLSANVEAI SDDSSETSSS 120
  121 DDDEEEEEDE DDALTMEHDN TSR

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [360-523]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ETVITTGDPL MQKIDISENP DKIYFIRRED GTVHRGQVLQ SRTTENAAAP DEYYVHYVGL  60
   61 NRRLDGWVGR HRISDNADDL GGITVLPAPP LAPDQPSTSR EMLAQQAAAA AAASSERQKR 120
  121 AANKDYYLSY CENSRYDYSD RKMTRYQKRR YDEINHVQKS HAEL

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 3.21
Match: 1wgsA
Description: Solution Structure of the Tudor Domain from Mouse Hypothetical Protein Homologous to Histone Acetyltransferase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription repressor activity 3.8081899455836 bayes_pls_golite062009
transcription regulator activity 3.52013719299428 bayes_pls_golite062009
chromatin binding 3.40552458111422 bayes_pls_golite062009
methylated histone residue binding 3.0459266457552 bayes_pls_golite062009
binding 2.96155744225842 bayes_pls_golite062009
protein binding 2.55372006358699 bayes_pls_golite062009
transcription elongation regulator activity 2.33879979958688 bayes_pls_golite062009
nucleic acid binding 2.19595603594923 bayes_pls_golite062009
DNA binding 2.0541708282373 bayes_pls_golite062009
histone binding 1.79126887796584 bayes_pls_golite062009
transcription activator activity 1.44969595924682 bayes_pls_golite062009
sequence-specific DNA binding 1.08214787027892 bayes_pls_golite062009
DNA-dependent ATPase activity 0.9574603809992 bayes_pls_golite062009
DNA helicase activity 0.67878641652425 bayes_pls_golite062009
RNA binding 0.49455178642198 bayes_pls_golite062009
ATP-dependent DNA helicase activity 0.426548109966398 bayes_pls_golite062009
general transcriptional repressor activity 0.402515314009813 bayes_pls_golite062009
transcription corepressor activity 0.227441509754587 bayes_pls_golite062009
catalytic activity 0.168308115787289 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [524-827]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TATQAALEKE HESITKIKYI DKLQFGNYEI DTWYFSPFPE EYGKARTLYV CEYCLKYMRF  60
   61 RSSYAYHLHE CDRRRPPGRE IYRKGNISIY EVNGKEESLY CQLLCLMAKL FLDHKVLYFD 120
  121 MDPFLFYILC ETDKEGSHIV GYFSKEKKSL ENYNVACILV LPPHQRKGFG KLLIAFSYEL 180
  181 SRKEGVIGSP EKPLSDLGRL SYRSYWAYTL LELMKTRCAP EQITIKELSE MSGITHDDII 240
  241 YTLQSMKMIK YWKGQNVICV TSKTIQDHLQ LPQFKQPKLT IDTDYLVWSP QTAAAVVRAP 300
  301 GNSG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 135.0
Match: 2givA
Description: No description for 2givA was found.

Predicted functions:

Term Confidence Notes
N-acetyltransferase activity 10.330867741687 bayes_pls_golite062009
histone acetyltransferase activity 10.2385402730839 bayes_pls_golite062009
lysine N-acetyltransferase activity 10.2385402730839 bayes_pls_golite062009
N-acyltransferase activity 10.2097972775096 bayes_pls_golite062009
acetyltransferase activity 9.5414870492393 bayes_pls_golite062009
acyltransferase activity 8.84144467104026 bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups 8.80032457938662 bayes_pls_golite062009
transferase activity, transferring acyl groups 8.58458341779614 bayes_pls_golite062009
histone acetyltransferase activity (H4-K16 specific) 8.54452063525878 bayes_pls_golite062009
7.30820970670781 bayes_pls_golite062009
5.22897636875434 bayes_pls_golite062009
H3 histone acetyltransferase activity 3.57980162499154 bayes_pls_golite062009
transferase activity 2.87429355361226 bayes_pls_golite062009
transcription regulator activity 2.24760844790231 bayes_pls_golite062009
transcription activator activity 2.22111981353244 bayes_pls_golite062009
nucleic acid binding 2.13750665291344 bayes_pls_golite062009
catalytic activity 1.97933499002461 bayes_pls_golite062009
transcription repressor activity 1.31507488567214 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.294475171667 bayes_pls_golite062009
binding 1.22537494136129 bayes_pls_golite062009
transcription coactivator activity 1.2180007740195 bayes_pls_golite062009
transcription factor binding 1.13174003342838 bayes_pls_golite062009
protein binding 1.12627968510377 bayes_pls_golite062009
myristoyltransferase activity 0.774009286200155 bayes_pls_golite062009
glycylpeptide N-tetradecanoyltransferase activity 0.774009286200155 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.605899196605446 bayes_pls_golite062009
histone binding 0.582104626133107 bayes_pls_golite062009
RNA binding 0.35120530780805 bayes_pls_golite062009
transcription cofactor activity 0.31196049232138 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
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