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Protein Overview: FBpp0300616, ple...

General Information:
Name(s) found: FBpp0300616 [FlyBase]
plexB-PA / FBpp0088246 [FlyBase]
Description(s) found:
Found 31 descriptions.
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  • type=protein; loc=4:complement(53644..53751,53817..53999,56500..57083,57142..61911,63540..64050); ID=FBpp0300616; name=plexB-PB; parent=FBgn0025740,FBtr0308297; dbxref=REFSEQ:NP_001245400,GB_protein:AFH06760,FlyBase:FBpp0300616,FlyBase_Annotation_IDs:CG17245-PB; MD5=dc0b6e4a3fd725a54d5fe13765e95cd1; length=2051; release=r5.56; species=Dmel; [FlyBase]
  • The gene plexin B is referred to in FlyBase by the symbol Dmel\plexB (CG17245, FBgn0025740). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 4:53434..64403. It has the cytological map location 102A1. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence that it is involved in the biological process</span>: axon guidance. 14 alleles are reported. The phenotypes of these alleles are annotated with: medial longitudinal fascicle; RP3 neuron; SNa; intersegmental nerve. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 2051 amino acids

    Gene Ontology:
    Cellular Component: membrane [IEA]
    intracellular [IEA]
    Biological Process: positive regulation of Rho protein signal transduction [NAS]
    motor axon guidance [NAS]
    signal transduction [IEA]
    negative regulation of Rac protein signal transduction [NAS]
    axon guidance [IDA][IGI][IMP]
    Molecular Function: protein binding [IPI]
    semaphorin receptor activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRKELYCAN IIHVLHVLCI IIILGSQHYC VNCIEELPAQ ALSPLNDIVA QFNLPSIPVQ  60
   61 STASSYGNRS IGNNIESVRD SQSKNYFTHM SFDFMHNVLF AGATNKILKL NENLRVLAEA 120
  121 VTGPLHDSPQ CHAGGCPEDI ETSLVNNFNK ILVVSYAHDG ILIACGSIRQ GACEIYSLPR 180
  181 FPATPQFFAV PLAANDENAS TYAFVGPARY AWKEEDILYV GTTFTNVGDY RHDVPAISSR 240
  241 RLDDLNYAEF SIQQSIINID VKYRDHFLVD YIYGFNSSEY AYFIIVQKKS HLADEAGYVT 300
  301 RLARICITDP NYDSYTEITV QCTATENNVD YNIVRDAKVT PASHKLAQKM GIKKDDHVLV 360
  361 TVFSPSREIS NQPESKSAMC IYSIKDIEDM FIENIHLCFN GTTKDRNLGY ISGTINDGRC 420
  421 PIVGSLGNIY NFCSVGLKIS GVSPITAHAL FHFDNVSVTS VTATSTTDQQ HSLAFLGTNM 480
  481 GVIKKVLLSG QSPGEYEEIV VDAGNRILPN TMMSPKKDFL YVLSQRKITK LRIEHCSVYT 540
  541 NCSACLESRD PFCGWCSLEK RCTVRSTCQR DTSASRWLSL GSGQQCIEFE SIIPEKIPIS 600
  601 ELSHLHLIIR TLPEPFNAKY RCVFGNSTPI DAEILENGLG CATPPLDERP LIPTNTDHIL 660
  661 VPLSVRSSET NKDFVSRNFA FFDCSHHGNC QECLQSSWGC NWCIFDNKCV HKSLQCRNIE 720
  721 NAVSTVGHCP HLKKNRPEIL LPVRVPIEIR LEIENLPKPK SAHAGFLCTI HIEAAQMLLP 780
  781 AHVESNKIVV CEKTPYFYEI NTHEYQAKVV VTWNFQHYVD TAIVTLYKCD VLGSHREHPD 840
  841 CSLCVTRDPK YKCAWCSNSC VYNETCIADK NSISSGSKSA IENECPLPRI DIIKPLSGPV 900
  901 EGGTLITIEG SNLGIREEDV RGKIFIGSVP CELENYQISV KIECRTGASL YEMSAPIKVA 960
  961 NDAGFTESSV QFHFKNVLLT GLYPTIGPRS GGTQLSLIGK FLNIGSTMRA FLDEYECHID1020
 1021 VTQASSSQVS CTTSEATQPE PIRSLHLVID GANRTLECQI STPSITNTNP TRSNFGSYQL1080
 1081 RSLPRQPCSI FNYTQDPRIM QIKPLRSFKS GGRVLTVHGI YLNSIQKPEL EVFYDNERVN1140
 1141 KTSCVVINSN QMECPSPPVN YKFETFKKTN RKMDTELHLQ NSSFQTETRY KNEYDRKKRR1200
 1201 ADFGDTFRLY TNAGSSANYF VNNNMDVTTF VKVHETQLNL QLSFVMDNVQ LVRNLNKYFH1260
 1261 DIRSTIVYLA DPKYLPFPND GVKLYKGDSL VIEGELLNLA ADEYDVNVTI GTSQCNITSL1320
 1321 ALNQLLCIPP EQQPLPTDEN GVDQSTDLPL VVVKVGRNLR FVIGYLKYDL NKPYVFSHAL1380
 1381 LVGILTVALL VVVFVIVLII FRRKSTQAER EYKRIQIQMI TLESNVRSEC KQAFAELQTD1440
 1441 MTDLTADLES TGIPTLDHVN YIMKVFFPGV SDHPILNSPK FREGSPQTNY DAAMVQFEQL1500
 1501 IGNKYFLLMF IETLEAQRSS FSIRDRVNVA SLIMVVLMNK MEYATEILKS LLLRLIDKSL1560
 1561 ASKHPQLMLR RTESVVEKML TNYLAICMYD YLKEYAGSNL FLLFKAIKHQ IEKGLVDAIT1620
 1621 NDARYSLSEE RLLHEQVTHS VVILHILQDD LDEKVQCRVN DWDTISQVKL KILDAIFKNT1680
 1681 PFSMRPSVNE VDLEWRHGRG GHLTLQDEDL TTKTVNGWKR LNTLAHYGVK ESAVMSLIAR1740
 1741 QNDNYHIPYS KNQNSAPYHN FYFINNSQSH IIINNDIESG LQQPRVYHLV KPNIPDHYMN1800
 1801 IKNSVLSGGS PAFQSHVVNN CNDRVNKTIP EVYLTRLLAT KGTIQKFVDD FFSIILTVNE1860
 1861 ELPPAVKWLF DLLDEAARRH DIADTDIVHA WKSNCLPLRF WVNFIKNPDF IFDVNKTYSV1920
 1921 DSCLSVIAQT FMDACSTSEH RLGKDSPSNK LLFAKDIPNY RIMVKEFYRD VSRLPQISDQ1980
 1981 EMSTAMQQLS VRQNEEFDTI SALKELYIYI TKYKDQIMES LETDINCRKM HLSRKLGNVA2040
 2041 ATLDGDCTSN C

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..774] PSI-BLAST 86.39794 No description for 2uzxB was found.
    2 View Details [775..1110] PSI-BLAST 14.69897 Low density lipoprotein (LDL) receptor YWTD domain; Low density lipoprotein (LDL) receptor, different EGF domains; Ligand-binding domain of low-density lipoprotein receptor
    3 View Details [1111..1374] deduced N/A No confident structure predictions are available.
    4 View Details [1375..1629] MSA 1.091938 View MSA. No confident structure predictions are available.
    5 View Details [1630..1742] PSI-BLAST 38.522879 No description for 2r2oA was found.
    6 View Details [1743..1837] deduced N/A No confident structure predictions are available.
    7 View Details [1838..2051] FFAS03 1.83 RAS-GTPASE-ACTIVATING DOMAIN OF HUMAN P120GAP

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • ErbB-2 class receptor binding
    		•  3.57510498491825 bayes_pls_golite062009
  • ErbB-3 class receptor binding
    		•  3.28829361940308 bayes_pls_golite062009
  • protein binding
    		•  2.30744405151563 bayes_pls_golite062009
  • receptor binding
    		•  1.70177010329948 bayes_pls_golite062009
  • binding
    		•  1.63967303762968 bayes_pls_golite062009
  • growth factor activity
    		•  0.59278308192712 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7
    Term Confidence Notes
  • GTPase regulator activity
    		•  3.95419914962876 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  3.92344045766502 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  3.59355391509857 bayes_pls_golite062009
  • GTPase activator activity
    		•  3.54666073519034 bayes_pls_golite062009
  • Ras GTPase activator activity
    		•  3.44103045903863 bayes_pls_golite062009
  • enzyme regulator activity
    		•  3.38464552177847 bayes_pls_golite062009
  • Rho GTPase activator activity
    		•  3.20097433590483 bayes_pls_golite062009
  • Rac GTPase activator activity
    		•  3.09114040497488 bayes_pls_golite062009
  • enzyme activator activity
    		•  3.08850936101798 bayes_pls_golite062009
  • protein binding
    		•  1.47356170396493 bayes_pls_golite062009
  • binding
    		•  0.90203495506529 bayes_pls_golite062009
  • ErbB-3 class receptor binding
    		•  0.283174381383763 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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