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Protein Overview: MBD-like-PA

General Information:
Name(s) found: MBD-like-PA / FBpp0081547 [FlyBase]
Description(s) found:
Found 21 descriptions.
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  • The gene MBD-like is referred to in FlyBase by the symbol Dmel\MBD-like (CG8208, FBgn0027950). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:5385487..5387255. It has the cytological map location 85D24. There is experimental evidence that it has the molecular function</span>: transcription regulator activity; transcription corepressor activity; methyl-CpG binding; histone deacetylase binding. There is experimental evidence that it is involved in the biological process</span>: negative regulation of transcription, DNA-dependent. 10 alleles are reported. The phenotype of these alleles is annotated with: embryonic heart. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 339 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IPI]
    polytene chromosome [IDA]
    NuRD complex [IPI]
    Biological Process: negative regulation of transcription, DNA-dependent [IDA]
    multicellular organismal development [TAS]
    Molecular Function: histone deacetylase binding [IPI]
    transcription regulator activity [IDA]
    transcription corepressor activity [IDA]
    [NOT]methyl-CpG binding [IDA][TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQMNPSVTIE RKRVDCSVLP KGWQRDEVRK SGSSANNNAS SNNNSSATAS SNNNNNKVDV  60
   61 FYYSPTGKRA EGKPQDIAIP DFQPGKMPHC ALPSPSISLY RCSAMPLPIA SGGGNGATSG 120
  121 SAANALKRKF ARSQGGNAAG AAGAAPPAAT ASSAATATAA SASPSTANRQ QQQIELSRAL 180
  181 RTDVSLVPPI RQTASIFKQP VTVIRNHKQD PAKAKNEPKH GTREKPKQLF WEKRLERLRA 240
  241 CHDSGEELDD ISLPKTIRTV GPNVNEQTVL QSVATALHML NAGVHGQSST KADLTKNAMA 300
  301 FMNPEQPLMH AVIISEDDIR KQEDRVGVAR RKLQDALKT

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..150] PSI-BLAST 3.154902 Solution structure of the matrix attachment region-binding domain of chicken MeCP2
    2 View Details [151..245] Pfam 3.031517 No description for PF01429.10 was found. No confident structure predictions are available.
    3 View Details [246..339] MSA 4.03799 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • DNA binding
    		•  4.42562920230852 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.33195028920652 bayes_pls_golite062009
  • transcription repressor activity
    		•  3.19559870959168 bayes_pls_golite062009
  • binding
    		•  3.0325775548747 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.97633361410339 bayes_pls_golite062009
  • transcription corepressor activity
    		•  2.70291730403476 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.42722575436746 bayes_pls_golite062009
  • chromatin binding
    		•  2.34423510884984 bayes_pls_golite062009
  • transcription factor activity
    		•  2.27540830787547 bayes_pls_golite062009
  • transcription factor binding
    		•  1.67549684739333 bayes_pls_golite062009
  • methyl-CpG binding
    		•  1.57450928488239 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.53919976183276 bayes_pls_golite062009
  • protein binding
    		•  1.48651016577672 bayes_pls_golite062009
  • unmethylated CpG binding
    		•  0.81114420503862 bayes_pls_golite062009
  • RNA binding
    		•  0.33612198087066 bayes_pls_golite062009
  • mRNA binding
    		•  0.28477406293958 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.82

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle