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View Structure Prediction Details

Protein: MBD-like-PA
Organism: Drosophila melanogaster
Length: 339 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MBD-like-PA.

Description E-value Query
Range
Subject
Range
gi|73987319 - gi|73987319|ref|XP_868590.1| PREDICTED: similar to methyl-CpG binding domain protein 3 isoform 3 [Ca...
360.0 [0..9] [339..1]

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Predicted Domain #1
Region A:
Residues: [1-150]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQMNPSVTIE RKRVDCSVLP KGWQRDEVRK SGSSANNNAS SNNNSSATAS SNNNNNKVDV  60
   61 FYYSPTGKRA EGKPQDIAIP DFQPGKMPHC ALPSPSISLY RCSAMPLPIA SGGGNGATSG 120
  121 SAANALKRKF ARSQGGNAAG AAGAAPPAAT 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.154902
Match: 1ub1A
Description: Solution structure of the matrix attachment region-binding domain of chicken MeCP2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
DNA binding 4.42562920230852 bayes_pls_golite062009
nucleic acid binding 4.33195028920652 bayes_pls_golite062009
transcription repressor activity 3.19559870959168 bayes_pls_golite062009
binding 3.0325775548747 bayes_pls_golite062009
transcription regulator activity 2.97633361410339 bayes_pls_golite062009
transcription corepressor activity 2.70291730403476 bayes_pls_golite062009
sequence-specific DNA binding 2.42722575436746 bayes_pls_golite062009
chromatin binding 2.34423510884984 bayes_pls_golite062009
transcription factor activity 2.27540830787547 bayes_pls_golite062009
transcription factor binding 1.67549684739333 bayes_pls_golite062009
methyl-CpG binding 1.57450928488239 bayes_pls_golite062009
transcription cofactor activity 1.53919976183276 bayes_pls_golite062009
protein binding 1.48651016577672 bayes_pls_golite062009
unmethylated CpG binding 0.81114420503862 bayes_pls_golite062009
RNA binding 0.33612198087066 bayes_pls_golite062009
mRNA binding 0.28477406293958 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [151-245]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ASSAATATAA SASPSTANRQ QQQIELSRAL RTDVSLVPPI RQTASIFKQP VTVIRNHKQD  60
   61 PAKAKNEPKH GTREKPKQLF WEKRLERLRA CHDSG

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 3.031517
Match: PF01429.10
Description: No description for PF01429.10 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [246-339]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EELDDISLPK TIRTVGPNVN EQTVLQSVAT ALHMLNAGVH GQSSTKADLT KNAMAFMNPE  60
   61 QPLMHAVIIS EDDIRKQEDR VGVARRKLQD ALKT

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle