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Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. A protein complex that possesses histone deacetylase activity. An approximately 2 MDa multi-subunit complex that exhibits ATP-dependent chromatin remodeling activity in addition to histone deacetylase (HDAC) activity, and has been shown to establish transcriptional repression of a number of target genes in vertebrates, invertebrates and fungi. Amongst its subunits, the NuRD complex contains histone deacetylases, histone binding proteins and Mi-2-like proteins. A protein complex that possesses activity that prevents or downregulates transcription. Any complex that mediates dynamic changes in eukaryotic chromatin. Any constituent part of the nucleoplasm, that part of the nuclear content other than the chromosomes or the nucleolus.

View Gene Ontology (GO) Term

GO TERM SUMMARY

Name: NuRD complex
Acc: GO:0016581
Aspect: Cellular Component
Desc: An approximately 2 MDa multi-subunit complex that exhibits ATP-dependent chromatin remodeling activity in addition to histone deacetylase (HDAC) activity, and has been shown to establish transcriptional repression of a number of target genes in vertebrates, invertebrates and fungi. Amongst its subunits, the NuRD complex contains histone deacetylases, histone binding proteins and Mi-2-like proteins.
Synonyms:
  • nucleosome remodeling and histone deacetylation complex
  • Mi-2 complex
  • NRD complex
Proteins in PDR annotated with:
   This term: 31 [Search]
   Term or descendants: 31 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0016581 - NuRD complex (interactive image map)

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