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Protein Overview: osk-PA

General Information:
Name(s) found: osk-PA / FBpp0081435 [FlyBase]
Description(s) found:
Found 30 descriptions.
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  • The gene oskar is referred to in FlyBase by the symbol Dmel\osk (CG10901, FBgn0003015). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:4760853..4764123. It has the cytological map location 85B7. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process</span>: regulation of mRNA stability; oocyte microtubule cytoskeleton polarization; visual learning; visual behavior; oogenesis; long-term memory; germ cell development; posterior abdomen determination; P granule organization. 109 alleles are reported. The phenotypes of these alleles are annotated with 32 unique terms, many of which group under: embryonic abdomen; organ system; embryonic segment; anatomical structure; embryonic tagma; female germline cyst; cuticle; abdominal segment 7; blastoderm embryo; cell part; embryonic abdominal segment 4; embryonic thorax; cephalopharyngeal skeleton; karyosome. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 606 amino acids

    Gene Ontology:
    Cellular Component: P granule [IDA][TAS]
    pole plasm [TAS]
    Biological Process: germ cell development [IMP]
    positive regulation of translation [NAS]
    anterior/posterior axis specification, embryo [TAS]
    pole cell fate determination [NAS]
    pole cell formation [TAS]
    P granule organization [IMP][TAS]
    oocyte microtubule cytoskeleton polarization [IMP]
    regulation of mRNA stability [IMP]
    visual learning [IMP]
    pole cell development [TAS]
    pole plasm assembly [NAS][TAS]
    posterior abdomen determination [IMP]
    visual behavior [IMP]
    oocyte anterior/posterior axis specification [NAS]
    pole plasm mRNA localization [TAS]
    long-term memory [IMP][TAS]
    pole plasm protein localization [NAS][TAS]
    oogenesis [IMP]
    regulation of oskar mRNA translation [TAS]
    maintenance of pole plasm mRNA location [NAS]
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAVTSEFPS KPISYTSTNT SAKTYYLKSV KKRVTTCFQQ LRDKLQSSGS FRKSSSSCLN  60
   61 QIFVRSDFSA CGERFRKIFK SARKTELPEL WKVPLVAHEL TSRQSSQQLQ VVARLFSSTQ 120
  121 ISTKEITYNS NSNTSENNMT IIESNYISVR EEYPDIDSEV RAILLSHAQN GITISSIKSE 180
  181 YRKLTGNPFP LHDNVTDFLL TIPNVTAECS ESGKRIFNLK ASLKNGHLLD MVLNQKERTS 240
  241 DYSSGAPSLE NIPRAPPRYW KNPFKRRALS QLNTSPRTVP KITDEKTKDI ATRPVSLHQM 300
  301 ANEAAESNWC YQDNWKHLNN FYQQASVNAP KMPVPINIYS PDAPEEPINL APPGHQPSCR 360
  361 TQSQKTEPTE NRHLGIFVHP FNGMNIMKRR HEMTPTPTIL TSGTYNDSLL TINSDYDAYL 420
  421 LDFPLMGDDF MLYLARMELK CRFRRHERVL QSGLCVSGLT INGARNRLKR VQLPEGTQII 480
  481 VNIGSVDIMR GKPLVQIEHD FRLLIKEMHN MRLVPILTNL APLGNYCHDK VLCDKIYRFN 540
  541 KFIRSECCHL KVIDIHSCLI NERGVVRFDC FQASPRQVTG SKEPYLFWNK IGRQRVLQVI 600
  601 ETSLEY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..143] deduced N/A No confident structure predictions are available.
    2 View Details [144..329] MSA 5.064981 View MSA. No confident structure predictions are available.
    3 View Details [330..396] deduced N/A No confident structure predictions are available.
    4 View Details [397..606] PSI-BLAST 41.045757 Thioesterase I, TAP

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • protein binding
    		•  1.5922433129317 bayes_pls_golite062009
  • binding
    		•  1.48824074563071 bayes_pls_golite062009
  • catalytic activity
    		•  1.15974340242656 bayes_pls_golite062009
  • hydrolase activity
    		•  0.45071330223777 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  0.0322595213897547 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle