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Protein Overview: Rpn5-PA

General Information:
Name(s) found: Rpn5-PA / FBpp0078278 [FlyBase]
Description(s) found:
Found 24 descriptions.
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  • The gene Rpn5 is referred to in FlyBase by the symbol Dmel\Rpn5 (CG1100, FBgn0028690). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:1615211..1617291. It has the cytological map location 83C4. There is experimental evidence that it has the molecular function</span>: endopeptidase activity. There is experimental evidence that it is involved in the biological process</span>: proteolysis. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 502 amino acids

    Gene Ontology:
    Cellular Component: proteasome regulatory particle [IDA][ISS]
    proteasome regulatory particle, lid subcomplex [ISS][NAS]
    Biological Process: proteolysis [IDA][ISS]
    Molecular Function: endopeptidase activity [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDTYLFDGGR ITKMEVDYEP ACNEKIPLAK ELAKKNPDAF HEAIEMMLQL EKQTRLGADM  60
   61 VSCSRVLVAI CQICFDASNW NALNEYVSLL VRRRSQLKQA VVKMIQECVT YVDKTPDKET 120
  121 KLKLIDTLRS VTEGKIYVEI ERARLTKILA DIKEADGDVA GAATVMEELQ VETYGSMDKR 180
  181 EKVELILEQM RLCLLKEDYV STQIIAKKIS IKFFDDPAQH DLKLKFYYLM IQLNRDTSFL 240
  241 NTSRHYQAIA EPPRKKTGLT PVDSAASTDE QKKKDDDKKK KEEDDKDKKP EVATEAEVEI 300
  301 ELTEEQKKEL TEKLVCAVLY CVLAPFDNEQ SDMMAHLSKN KKLEEVPAYK EILRLFMSKE 360
  361 LINFDTFNAD FGLVLAENEM FKDSTKHGKK CITELKDRLI EHNIRIIAMY YSRLHLARMS 420
  421 ELLNLPTSRC EEYLSKLANT DTIRVKIDRP AGIIYFTQKK SASDILNNWA TDVNQLMSLV 480
  481 NKTCHLINKE ECVYSVMCAV ED

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..215] MSA 3.342989 View MSA. No confident structure predictions are available.
    2 View Details [216..381] deduced N/A No confident structure predictions are available.
    3 View Details [382..502] PSI-BLAST 11.045757 Solution structure of the PCI domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • binding
    		•  2.69037212939381 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.51073261475907 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.46972120642276 bayes_pls_golite062009
  • DNA binding
    		•  2.34739506178536 bayes_pls_golite062009
  • hydrolase activity
    		•  2.30467124306022 bayes_pls_golite062009
  • transcription factor activity
    		•  1.63630978976366 bayes_pls_golite062009
  • protein binding
    		•  0.653872239015235 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.42089068572633 bayes_pls_golite062009
  • transcription activator activity
    		•  0.177144423226603 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  0.136726704233672 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  0.118016217031359 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.0832641811501794 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle