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View Structure Prediction Details

Protein: Rpn5-PA
Organism: Drosophila melanogaster
Length: 502 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Rpn5-PA.

Description E-value Query
Range
Subject
Range
gi|195146356, gi... - gi|195146356|ref|XP_002014152.1| GL24524 [Drosophila persimilis], gi|194103095|gb|EDW25138.1| GL2452...
gi|54638798|gb|E... - GA10700-PA [Drosophila pseudoobscura], GA10700 [Drosophila pseudoobscura pseudoobscura]
gi|125775764, gi... - gi|54638798|gb|EAL28200.1| GA10700 [Drosophila pseudoobscura pseudoobscura], gi|125775764|ref|XP_001...
350.0 [0..1] [502..1]

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Predicted Domain #1
Region A:
Residues: [1-215]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDTYLFDGGR ITKMEVDYEP ACNEKIPLAK ELAKKNPDAF HEAIEMMLQL EKQTRLGADM  60
   61 VSCSRVLVAI CQICFDASNW NALNEYVSLL VRRRSQLKQA VVKMIQECVT YVDKTPDKET 120
  121 KLKLIDTLRS VTEGKIYVEI ERARLTKILA DIKEADGDVA GAATVMEELQ VETYGSMDKR 180
  181 EKVELILEQM RLCLLKEDYV STQIIAKKIS IKFFD

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [216-381]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DPAQHDLKLK FYYLMIQLNR DTSFLNTSRH YQAIAEPPRK KTGLTPVDSA ASTDEQKKKD  60
   61 DDKKKKEEDD KDKKPEVATE AEVEIELTEE QKKELTEKLV CAVLYCVLAP FDNEQSDMMA 120
  121 HLSKNKKLEE VPAYKEILRL FMSKELINFD TFNADFGLVL AENEMF

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [382-502]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KDSTKHGKKC ITELKDRLIE HNIRIIAMYY SRLHLARMSE LLNLPTSRCE EYLSKLANTD  60
   61 TIRVKIDRPA GIIYFTQKKS ASDILNNWAT DVNQLMSLVN KTCHLINKEE CVYSVMCAVE 120
  121 D

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.045757
Match: 1ufmA
Description: Solution structure of the PCI domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.69037212939381 bayes_pls_golite062009
nucleic acid binding 2.51073261475907 bayes_pls_golite062009
transcription regulator activity 2.46972120642276 bayes_pls_golite062009
DNA binding 2.34739506178536 bayes_pls_golite062009
hydrolase activity 2.30467124306022 bayes_pls_golite062009
transcription factor activity 1.63630978976366 bayes_pls_golite062009
protein binding 0.653872239015235 bayes_pls_golite062009
sequence-specific DNA binding 0.42089068572633 bayes_pls_golite062009
transcription activator activity 0.177144423226603 bayes_pls_golite062009
ubiquitin-protein ligase activity 0.136726704233672 bayes_pls_golite062009
small conjugating protein ligase activity 0.118016217031359 bayes_pls_golite062009
transcription repressor activity 0.0832641811501794 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle