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Protein Overview: gbb-PA, FBpp0309939

General Information:
Name(s) found: FBpp0309939 [FlyBase]
gbb-PA / FBpp0072036 [FlyBase]
Description(s) found:
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  • gi|7291653|gb|AAF47075.1| glass bottom boat [Drosophila melanogaster] [NCBI NR]
  • pir||A43918 TGF-beta-related protein 60A precursor - fruit fly (Drosophila melanogaster) [NCBI NR]
  • gi|17137520|ref|NP_477340.1| glass bottom boat [Drosophila melanogaster] [NCBI NR]
  • gi|156730|gb|AAA28307.1| 60A protein [NCBI NR]
  • gi|156728|gb|AAA28306.1| 'precursor TGF-B-like protein from 60A gene'; Potential glycosylation sites are located at positions 421-429, 1117-1125, and 1153-1161 [Drosophila melanogaster] [NCBI NR]
  • gi|112828|sp|P27091.1|60A_DROME RecName: Full=Protein 60A; AltName: Full=Protein glass bottom boat; Flags: Precursor [NCBI NR]
  • Protein 60A OS=Drosophila melanogaster GN=gbb PE=1 SV=1 [Swiss-Prot]
  • type=protein; loc=2R:19739278..19740645; ID=FBpp0309939; name=gbb-PB; parent=FBgn0024234,FBtr0343274; dbxref=FlyBase:FBpp0309939,FlyBase_Annotation_IDs:CG5562-PB; MD5=dda5982d440e1461660690c492a45c2f; length=455; release=r5.56; species=Dmel; [FlyBase]
  • The gene glass bottom boat is referred to in FlyBase by the symbol Dmel\gbb (CG5562, FBgn0024234). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:19739106..19740772. It has the cytological map location 60A3-60A4. Based on sequence similarity, it is predicted to have molecular function</span>: transforming growth factor beta receptor binding. There is experimental evidence that it is involved in the biological process</span>: neuromuscular synaptic transmission; positive regulation of muscle organ development; ovarian follicle cell development; imaginal disc-derived wing vein morphogenesis; imaginal disc-derived wing vein specification; wing disc pattern formation. 19 alleles are reported. The phenotypes of these alleles are annotated with 46 unique terms, many of which group under: adult segment; adult mesothoracic segment; organ system; peripheral nervous system; nervous system; wing cell; spiracle; external compound sense organ; integumentary specialisation; imaginal precursor. It has one annotated transcript and one annotated polypeptide. [FlyBase]
  • >CG5562-PA translation from_gene[CG5562 gbb FBgn0024234] seq_release:3 mol_weight=51688 cds_boundaries:(2R:18,895,323..18,896,687[+]) aa_length:455 transcript_info:[CG5562-RA seq_release:3] gene_info:[gene symbol:gbb FBgn0024234 gene_boundaries:(2R:18, [hmr_yeast5_DM3-1_pombe.fasta]
  • (P27091) 60A protein precursor (Glass bottom boat protein) [DrosMelano7227.FASTAC.txt]
  • (AE003462) gbb gene product [Drosophila melanogaster] [yeastflysequest.fasta]
  • CG5562-PA [Drosophila melanogaster]gi|17137520|ref|NP_477340.1| CG5562-PA [Drosophila melanogaster]gi|283697|pir||A43918 TGF-beta-related protein 60A precursor - fruit fly (Drosophila melanogaster)gi|112828|sp|P27091|60A_DROME 60A protein precursor (G [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=2R:19739278..19740645; ID=FBpp0072036; name=gbb-PA; parent=FBgn0024234,FBtr0072127; dbxref=FlyBase:FBpp0072036,FlyBase_Annotation_IDs:CG5562-PA,GB_protein:AAF47075.1,REFSEQ:NP_477340,GB_protein:AAF47075; MD5=dda5982d440e1461660690c492a45 [fly-100309-contam.fasta]
  • 60A protein [nr-271106-contam.fasta]
  • 'precursor TGF-B-like protein from 60A gene'; Potential glycosylation sites are located at positions 421-429, 1117-1125, and 1153-1161 [nr-271106-contam.fasta]
  • CG5562-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Protein 60A precursor (Protein glass bottom boat) [nr-271106-contam.fasta]
  • glass bottom boat CG5562-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=2R:19739278..19740645; ID=FBpp0072036; name=gbb-PA; parent=FBgn0024234,FBtr0072127; dbxref=FlyBase:FBpp0072036,FlyBase_Annotation_IDs:CG5562-PA,GB_protein:AAF47075.1,REFSEQ:NP_477340,GB_protein:AAF47075; MD5=dda5982d440e1461660690c492a45c2f; length=455; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=2R:19739278..19740645; ID=FBpp0072036; name=gbb-PA; parent=FBgn0024234,FBtr0072127; dbxref=FlyBase:FBpp0072036,FlyBase_Annotation_IDs:CG5562-PA,GB_protein:AAF47075.1,REFSEQ:NP_477340,GB_protein:AAF47075; MD5=dda5982d440e1461660690c492a45c2f; length=455; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • type=protein; loc=2R:19739278..19740645; ID=FBpp0072036; name=gbb-PA; parent=FBgn0024234,FBtr0072127; dbxref=FlyBase:FBpp0072036,FlyBase_Annotation_IDs:CG5562-PA,GB_protein:AAF47075.1,REFSEQ:NP_477340,GB_protein:AAF47075,FlyMine:FBpp0072036,modMine:FBpp0072036; MD5=dda5982d440e1461660690c492a45c2f; length=455; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=2R:23851755..23853122; ID=FBpp0072036; name=gbb-PA; parent=FBgn0024234,FBtr0072127; dbxref=FlyBase:FBpp0072036,FlyBase_Annotation_IDs:CG5562-PA,GB_protein:AAF47075.1,REFSEQ:NP_477340,GB_protein:AAF47075,FlyMine:FBpp0072036,modMine:FBpp0072036; MD5=dda5982d440e1461660690c492a45c2f; length=455; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=2R:23851755..23853122; ID=FBpp0309939; name=gbb-PB; parent=FBgn0024234,FBtr0343274; dbxref=GB_protein:AHN56581,REFSEQ:NP_001286786,FlyBase:FBpp0309939,FlyBase_Annotation_IDs:CG5562-PB; MD5=dda5982d440e1461660690c492a45c2f; length=455; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=2R:23851755..23853122; ID=FBpp0072036; name=gbb-PA; parent=FBgn0024234,FBtr0072127; dbxref=FlyBase:FBpp0072036,FlyBase_Annotation_IDs:CG5562-PA,GB_protein:AAF47075.1,REFSEQ:NP_477340,GB_protein:AAF47075,FlyMine:FBpp0072036,modMine:FBpp0072036; MD5=dda5982d440e1461660690c492a45c2f; length=455; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • type=protein; loc=2R:23851755..23853122; ID=FBpp0309939; name=gbb-PB; parent=FBgn0024234,FBtr0343274; dbxref=GB_protein:AHN56581,REFSEQ:NP_001286786,FlyBase:FBpp0309939,FlyBase_Annotation_IDs:CG5562-PB; MD5=dda5982d440e1461660690c492a45c2f; length=455; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • Isoform of P27091, Glass bottom boat, isoform B OS=Drosophila melanogaster GN=gbb PE=3 SV=1 [DROME.fasta.20160308]
  • FBpp0072036 type=protein; loc=2R:23851755..23853122; ID=FBpp0072036; name=gbb-PA; parent=FBgn0024234,FBtr0072127; dbxref=FlyBase:FBpp0072036,FlyBase_Annotation_IDs:CG5562-PA,GB_protein:AAF47075.1,REFSEQ:NP_477340,GB_protein:AAF47075,FlyMine:FBpp0072036,modMine:FBpp0072036; MD5=dda5982d440e1461660690c492a45c2f; length=455; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • FBpp0309939 type=protein; loc=2R:23851755..23853122; ID=FBpp0309939; name=gbb-PB; parent=FBgn0024234,FBtr0343274; dbxref=GB_protein:AHN56581,REFSEQ:NP_001286786,FlyBase:FBpp0309939,FlyBase_Annotation_IDs:CG5562-PB; MD5=dda5982d440e1461660690c492a45c2f; length=455; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=2R:23851755..23853122; ID=FBpp0072036; name=gbb-PA; parent=FBgn0024234,FBtr0072127; dbxref=FlyBase:FBpp0072036,FlyBase_Annotation_IDs:CG5562-PA,GB_protein:AAF47075.1,REFSEQ:NP_477340,GB_protein:AAF47075,UniProt/Swiss-Prot:P27091,FlyMine:FBpp0072036,modMine:FBpp0072036; MD5=dda5982d440e1461660690c492a45c2f; length=455; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
  • type=protein; loc=2R:23851755..23853122; ID=FBpp0309939; name=gbb-PB; parent=FBgn0024234,FBtr0343274; dbxref=GB_protein:AHN56581,REFSEQ:NP_001286786,FlyBase:FBpp0309939,FlyBase_Annotation_IDs:CG5562-PB,UniProt/Swiss-Prot:P27091; MD5=dda5982d440e1461660690c492a45c2f; length=455; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 455 amino acids

    Gene Ontology:
    Cellular Component: extracellular region [ISS]
    Biological Process: dorsal closure [TAS]
    wing disc pattern formation [IMP]
    neuromuscular synaptic transmission [IMP]
    BMP signaling pathway [ISS]
    ovarian follicle cell development [IMP]
    transforming growth factor beta receptor signaling pathway [NAS]
    positive regulation of muscle organ development [IGI]
    imaginal disc-derived wing vein morphogenesis [IMP]
    imaginal disc-derived wing vein specification [IMP]
    growth [IEA]
    Molecular Function: growth factor activity [IEA]
    transforming growth factor beta receptor binding [ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGLRNTSEA VAVLASLGLG MVLLMFVATT PPAVEATQSG IYIDNGKDQT IMHRVLSEDD  60
   61 KLDVSYEILE FLGIAERPTH LSSHQLSLRK SAPKFLLDVY HRITAEEGLS DQDEDDDYER 120
  121 GHRSRRSADL EEDEGEQQKN FITDLDKRAI DESDIIMTFL NKRHHNVDEL RHEHGRRLWF 180
  181 DVSNVPNDNY LVMAELRIYQ NANEGKWLTA NREFTITVYA IGTGTLGQHT MEPLSSVNTT 240
  241 GDYVGWLELN VTEGLHEWLV KSKDNHGIYI GAHAVNRPDR EVKLDDIGLI HRKVDDEFQP 300
  301 FMIGFFRGPE LIKATAHSSH HRSKRSASHP RKRKKSVSPN NVPLLEPMES TRSCQMQTLY 360
  361 IDFKDLGWHD WIIAPEGYGA FYCSGECNFP LNAHMNATNH AIVQTLVHLL EPKKVPKPCC 420
  421 APTRLGALPV LYHLNDENVN LKKYRNMIVK SCGCH

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..153] MSA 9.302995 View MSA. No confident structure predictions are available.
    2 View Details [154..304] MSA 8.415994 View MSA. No confident structure predictions are available.
    3 View Details [305..455] PSI-BLAST 41.0 BONE MORPHOGENETIC PROTEIN-7

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • type II transforming growth factor beta receptor binding
    		•  6.0109591386237 bayes_pls_golite062009
  • vascular endothelial growth factor receptor 1 binding
    		•  5.35645409779291 bayes_pls_golite062009
  • receptor serine/threonine kinase binding
    		•  4.8369569327215 bayes_pls_golite062009
  • receptor binding
    		•  4.70889547404918 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase binding
    		•  4.69128752159226 bayes_pls_golite062009
  • transforming growth factor beta receptor binding
    		•  4.69128752159226 bayes_pls_golite062009
  • growth factor activity
    		•  4.01406832911234 bayes_pls_golite062009
  • platelet-derived growth factor receptor binding
    		•  4.00406636948119 bayes_pls_golite062009
  • cytokine activity
    		•  3.61376517935324 bayes_pls_golite062009
  • fibronectin binding
    		•  3.5904111848601 bayes_pls_golite062009
  • protein binding
    		•  3.41839891062651 bayes_pls_golite062009
  • growth factor binding
    		•  3.23153419905493 bayes_pls_golite062009
  • cell surface binding
    		•  2.9725198156666 bayes_pls_golite062009
  • binding
    		•  2.85157432803513 bayes_pls_golite062009
  • vascular endothelial growth factor receptor binding
    		•  2.76400237542695 bayes_pls_golite062009
  • vascular endothelial growth factor receptor 2 binding
    		•  2.68337714155403 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  2.49731836866959 bayes_pls_golite062009
  • glial cell line-derived neurotrophic factor receptor binding
    		•  2.42595321135263 bayes_pls_golite062009
  • heparin binding
    		•  2.11784489374422 bayes_pls_golite062009
  • hormone activity
    		•  2.10500409590202 bayes_pls_golite062009
  • platelet-derived growth factor binding
    		•  2.01091405432331 bayes_pls_golite062009
  • protein dimerization activity
    		•  1.82426827198541 bayes_pls_golite062009
  • collagen binding
    		•  1.64555624988816 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.57604808199471 bayes_pls_golite062009
  • signal transducer activity
    		•  1.40678896068326 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.40678896068326 bayes_pls_golite062009
  • protein homodimerization activity
    		•  1.377005150119 bayes_pls_golite062009
  • identical protein binding
    		•  1.18858126900765 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.1841101716474 bayes_pls_golite062009
  • polysaccharide binding
    		•  1.16191864095271 bayes_pls_golite062009
  • kinase activity
    		•  1.15484804727089 bayes_pls_golite062009
  • protein kinase activity
    		•  1.13177677975696 bayes_pls_golite062009
  • cytokine binding
    		•  1.11655568277071 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.07701076060466 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.01600179397846 bayes_pls_golite062009
  • transcription activator activity
    		•  1.00293277340817 bayes_pls_golite062009
  • SMAD binding
    		•  0.918765103972039 bayes_pls_golite062009
  • morphogen activity
    		•  0.91146826241391 bayes_pls_golite062009
  • pattern binding
    		•  0.90497366619649 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.88308874209284 bayes_pls_golite062009
  • neurotrophin receptor binding
    		•  0.81172494974121 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.675252100191059 bayes_pls_golite062009
  • transforming growth factor beta binding
    		•  0.539891088283499 bayes_pls_golite062009
  • vascular endothelial growth factor receptor 3 binding
    		•  0.385087890820529 bayes_pls_golite062009
  • catalytic activity
    		•  0.105223830172599 bayes_pls_golite062009
  • follicle-stimulating hormone activity
    		•  0.0768613588095315 bayes_pls_golite062009
  • carbohydrate binding
    		•  0.0235054088545197 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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