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View Structure Prediction Details

Protein: gbb-PA, FBpp0309939
Organism: Drosophila melanogaster
Length: 455 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gbb-PA, FBpp0309939.

Description E-value Query
Range
Subject
Range
gi|109471415, gi... - gi|34860862|ref|XP_342592.1| PREDICTED: bone morphogenetic protein 7 [Rattus norvegicus], gi|1490300...
BMP7_MOUSE - Bone morphogenetic protein 7 OS=Mus musculus GN=Bmp7 PE=1 SV=2
354.0 [0..24] [455..14]

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Predicted Domain #1
Region A:
Residues: [1-153]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGLRNTSEA VAVLASLGLG MVLLMFVATT PPAVEATQSG IYIDNGKDQT IMHRVLSEDD  60
   61 KLDVSYEILE FLGIAERPTH LSSHQLSLRK SAPKFLLDVY HRITAEEGLS DQDEDDDYER 120
  121 GHRSRRSADL EEDEGEQQKN FITDLDKRAI DES

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [154-304]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DIIMTFLNKR HHNVDELRHE HGRRLWFDVS NVPNDNYLVM AELRIYQNAN EGKWLTANRE  60
   61 FTITVYAIGT GTLGQHTMEP LSSVNTTGDY VGWLELNVTE GLHEWLVKSK DNHGIYIGAH 120
  121 AVNRPDREVK LDDIGLIHRK VDDEFQPFMI G

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [305-455]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FFRGPELIKA TAHSSHHRSK RSASHPRKRK KSVSPNNVPL LEPMESTRSC QMQTLYIDFK  60
   61 DLGWHDWIIA PEGYGAFYCS GECNFPLNAH MNATNHAIVQ TLVHLLEPKK VPKPCCAPTR 120
  121 LGALPVLYHL NDENVNLKKY RNMIVKSCGC H

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 41.0
Match: 1bmpA
Description: BONE MORPHOGENETIC PROTEIN-7
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
type II transforming growth factor beta receptor binding 6.0109591386237 bayes_pls_golite062009
vascular endothelial growth factor receptor 1 binding 5.35645409779291 bayes_pls_golite062009
receptor serine/threonine kinase binding 4.8369569327215 bayes_pls_golite062009
receptor binding 4.70889547404918 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase binding 4.69128752159226 bayes_pls_golite062009
transforming growth factor beta receptor binding 4.69128752159226 bayes_pls_golite062009
growth factor activity 4.01406832911234 bayes_pls_golite062009
platelet-derived growth factor receptor binding 4.00406636948119 bayes_pls_golite062009
cytokine activity 3.61376517935324 bayes_pls_golite062009
fibronectin binding 3.5904111848601 bayes_pls_golite062009
protein binding 3.41839891062651 bayes_pls_golite062009
growth factor binding 3.23153419905493 bayes_pls_golite062009
cell surface binding 2.9725198156666 bayes_pls_golite062009
binding 2.85157432803513 bayes_pls_golite062009
vascular endothelial growth factor receptor binding 2.76400237542695 bayes_pls_golite062009
vascular endothelial growth factor receptor 2 binding 2.68337714155403 bayes_pls_golite062009
glycosaminoglycan binding 2.49731836866959 bayes_pls_golite062009
glial cell line-derived neurotrophic factor receptor binding 2.42595321135263 bayes_pls_golite062009
heparin binding 2.11784489374422 bayes_pls_golite062009
hormone activity 2.10500409590202 bayes_pls_golite062009
platelet-derived growth factor binding 2.01091405432331 bayes_pls_golite062009
protein dimerization activity 1.82426827198541 bayes_pls_golite062009
collagen binding 1.64555624988816 bayes_pls_golite062009
transcription regulator activity 1.57604808199471 bayes_pls_golite062009
signal transducer activity 1.40678896068326 bayes_pls_golite062009
molecular transducer activity 1.40678896068326 bayes_pls_golite062009
protein homodimerization activity 1.377005150119 bayes_pls_golite062009
identical protein binding 1.18858126900765 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.1841101716474 bayes_pls_golite062009
polysaccharide binding 1.16191864095271 bayes_pls_golite062009
kinase activity 1.15484804727089 bayes_pls_golite062009
protein kinase activity 1.13177677975696 bayes_pls_golite062009
cytokine binding 1.11655568277071 bayes_pls_golite062009
transcription repressor activity 1.07701076060466 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.01600179397846 bayes_pls_golite062009
transcription activator activity 1.00293277340817 bayes_pls_golite062009
SMAD binding 0.918765103972039 bayes_pls_golite062009
morphogen activity 0.91146826241391 bayes_pls_golite062009
pattern binding 0.90497366619649 bayes_pls_golite062009
protein heterodimerization activity 0.88308874209284 bayes_pls_golite062009
neurotrophin receptor binding 0.81172494974121 bayes_pls_golite062009
protein serine/threonine kinase activity 0.675252100191059 bayes_pls_golite062009
transforming growth factor beta binding 0.539891088283499 bayes_pls_golite062009
vascular endothelial growth factor receptor 3 binding 0.385087890820529 bayes_pls_golite062009
catalytic activity 0.105223830172599 bayes_pls_golite062009
follicle-stimulating hormone activity 0.0768613588095315 bayes_pls_golite062009
carbohydrate binding 0.0235054088545197 bayes_pls_golite062009

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