YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: Rep-PA

General Information:
Name(s) found: Rep-PA / FBpp0085658 [FlyBase]
Description(s) found:
Found 23 descriptions.
SHOW ALL
  • The gene Rab escort protein is referred to in FlyBase by the symbol Dmel\Rep (CG8432, FBgn0026378). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:15379596..15381630. It has the cytological map location 56D13. Based on sequence similarity, it is predicted to have molecular function</span>: Rab GTPase binding; Rab geranylgeranyltransferase activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: protein amino acid geranylgeranylation; intracellular protein transport. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 511 amino acids

    Gene Ontology:
    Cellular Component: perinuclear region of cytoplasm [IDA]
    Rab-protein geranylgeranyltransferase complex [ISS]
    cytoplasm [ISS]
    synaptic vesicle [NAS]
    membrane [ISS]
    spindle pole [IDA]
    aster [IDA]
    Biological Process: vesicle-mediated transport [NAS]
    regulation of GTPase activity [IEA]
    intracellular protein transport [ISS]
    neurotransmitter secretion [NAS]
    protein amino acid geranylgeranylation [ISS]
    Molecular Function: Rab geranylgeranyltransferase activity [ISS]
    Rab GTPase binding [ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLDDLPEQFD LVVIGTGFTE SCIAAAGSRI GKSVLHLDSN EYYGDVWSSF SMDALCARLD  60
   61 QEVEPHSALR NARYTWHSME KESETDAQSW NRDSVLAKSR RFSLDLCPRI LYAAGELVQL 120
  121 LIKSNICRYA EFRAVDHVCM RHNGEIVSVP CSRSDVFNTK TLTIVEKRLL MKFLTACNDY 180
  181 GEDKCNEDSL EFRGRTFLEY LQAQRVTEKI SSCVMQAIAM CGPSTSFEEG MQRTQRFLGS 240
  241 LGRYGNTPFL FPMYGCGELP QCFCRLCAVY GGIYCLKRAV DDIALDSNSN EFLLSSAGKT 300
  301 LRAKNVVSAP GYTPVSKGIE LKPHISRGLF ISSSPLGNEE LNKGGGGVNL LRLLDNEGGR 360
  361 EAFLIQLSHY TGACPEGLYI FHLTTPALSE DPASDLAIFT SQLFDQSDAQ IIFSSYFTIA 420
  421 AQSSKSPAAE HIYYTDPPTY ELDYDAAIAN ARDIFGKMFP DADFLPRAPD PEEIVVDGED 480
  481 PSALNEHTLP EDLRAQLHDM QQATQEMDIQ E

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..99] PSI-BLAST 18.522879 UDP-galactopyranose mutase, N-terminal domain; UDP-galactopyranose mutases
    2 View Details [100..511] PSI-BLAST 62.0 Rab escort protein 1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • Rab geranylgeranyltransferase activity
    		•  9.99062899455963 bayes_pls_golite062009
  • protein prenyltransferase activity
    		•  9.51472596751319 bayes_pls_golite062009
  • protein geranylgeranyltransferase activity
    		•  9.04655134250827 bayes_pls_golite062009
  • prenyltransferase activity
    		•  7.67724812902621 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  1.82777033221452 bayes_pls_golite062009
  • GTPase regulator activity
    		•  1.69589677829425 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  1.67690582043816 bayes_pls_golite062009
  • transporter activity
    		•  1.29839290134235 bayes_pls_golite062009
  • binding
    		•  1.28745887296004 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.07862908893913 bayes_pls_golite062009
  • catalytic activity
    		•  1.03127962968326 bayes_pls_golite062009
  • enzyme regulator activity
    		•  1.00883251592654 bayes_pls_golite062009
  • amine oxidase activity
    		•  0.93095855430028 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.556967966402473 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.450613852654832 bayes_pls_golite062009
  • GDP-dissociation inhibitor activity
    		•  0.387378304822822 bayes_pls_golite062009
  • protein binding
    		•  0.347133050347128 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.317465086590155 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.31459693204333 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors
    		•  0.2899722058349 bayes_pls_golite062009
  • transferase activity
    		•  0.240250859292614 bayes_pls_golite062009
  • DNA binding
    		•  0.175917747732026 bayes_pls_golite062009
  • Rab GTPase binding
    		•  0.152281351170071 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle