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Protein Overview: BCL2_RAT

General Information:
Name(s) found: BCL2_RAT [Swiss-Prot]
Description(s) found:
Found 9 descriptions.
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  • Apoptosis regulator Bcl-2 OS=Rattus norvegicus GN=Bcl2 PE=1 SV=2 [Swiss-Prot]
    • Organism: Rattus norvegicus
    Length: 236 amino acids

    Gene Ontology:
    Cellular Component: myelin sheath [UNKNOWN][IEA]
    microsome [UNKNOWN][IEA]
    endoplasmic reticulum [UNKNOWN][IEA]
    protein phosphatase type 2A complex [UNKNOWN][IEA]
    mitochondrial outer membrane [UNKNOWN][IEA]
    intracellular [UNKNOWN][IEA]
    membrane fraction [UNKNOWN][IEA]
    endoplasmic reticulum membrane [UNKNOWN][IEA]
    nucleus [UNKNOWN][IEA]
    nuclear membrane [UNKNOWN][IEA]
    calcineurin complex [UNKNOWN][IEA]
    mitochondrial membrane [UNKNOWN]
    cytoplasm [UNKNOWN][IDA]
    mitochondrion [UNKNOWN][IDA]
    membrane [UNKNOWN][IEA]
    integral to membrane [IEA]
    cytosol [UNKNOWN][IEA]
    Biological Process: response to estrogen stimulus [IEP]
    male gonad development [UNKNOWN][IEA]
    post-embryonic development [UNKNOWN][IEA]
    T cell lineage commitment [UNKNOWN][IEA]
    actin filament organization [UNKNOWN][IEA]
    regulation of programmed cell death [UNKNOWN]
    immune system development [UNKNOWN][IEA]
    negative regulation of cellular pH reduction [UNKNOWN][IEA]
    positive regulation of cell growth [UNKNOWN]
    positive regulation of developmental pigmentation [UNKNOWN][IEA]
    response to hypoxia [IEP]
    cell death [UNKNOWN][IEA]
    kidney development [UNKNOWN]
    negative regulation of cell growth [UNKNOWN][IEA]
    regulation of mitochondrial membrane potential [ISS]
    axonogenesis [UNKNOWN]
    regulation of catalytic activity [UNKNOWN]
    regulation of calcium ion transport [UNKNOWN][IEA]
    glial cell apoptosis [IEP]
    neuron apoptosis [UNKNOWN]
    positive regulation of peptidyl-serine phosphorylation [UNKNOWN][IEA]
    response to organic substance [IEP]
    cell morphogenesis [UNKNOWN][IEA]
    negative regulation of mitotic cell cycle [UNKNOWN][IEA]
    response to organic cyclic substance [IEP]
    response to hydrogen peroxide [UNKNOWN][IEA]
    regulation of mitochondrial membrane permeability [ISS]
    growth [UNKNOWN]
    activation of pro-apoptotic gene products [UNKNOWN]
    response to corticosterone stimulus [IEP]
    regulation of cell-matrix adhesion [UNKNOWN][IEA]
    glomerulus development [UNKNOWN][IEA]
    positive regulation of catalytic activity [UNKNOWN][IEA]
    release of cytochrome c from mitochondria [ISS]
    hair follicle morphogenesis [IEA]
    axon regeneration [UNKNOWN][IEA]
    cell proliferation [UNKNOWN]
    organ growth [UNKNOWN][IEA]
    negative regulation of cell proliferation [UNKNOWN]
    positive regulation of neuron maturation [UNKNOWN][IEA]
    hemopoiesis [UNKNOWN][IEA]
    positive regulation of cell proliferation [IEA]
    spleen development [UNKNOWN][IEA]
    positive regulation of multicellular organism growth [UNKNOWN][IEA]
    negative regulation of neuron apoptosis [UNKNOWN][IEA]
    thymus development [UNKNOWN][IEA]
    response to heat [IEP]
    response to glucocorticoid stimulus [UNKNOWN]
    response to protein stimulus [UNKNOWN][IEA]
    cell-cell adhesion [UNKNOWN][IEA]
    response to L-ascorbic acid [IEP]
    T cell differentiation in the thymus [UNKNOWN][IEA]
    protein polyubiquitination [UNKNOWN]
    regulation of protein heterodimerization activity [UNKNOWN][IEA]
    gland morphogenesis [UNKNOWN][IEA]
    CD8-positive, alpha-beta T cell lineage commitment [UNKNOWN][IEA]
    regulation of protein homodimerization activity [UNKNOWN][IEA]
    gut morphogenesis [UNKNOWN][IEA]
    response to nicotine [UNKNOWN][IEP]
    response to steroid hormone stimulus [UNKNOWN]
    B cell homeostasis [UNKNOWN][IEA]
    response to stress [IEP]
    ovarian follicle development [UNKNOWN][IEP]
    behavioral fear response [UNKNOWN][IEA]
    leukocyte homeostasis [UNKNOWN]
    metanephros development [UNKNOWN]
    ureteric bud development [UNKNOWN][IEA]
    branching involved in ureteric bud morphogenesis [UNKNOWN][IEA]
    negative regulation of calcium ion transport into cytosol [UNKNOWN][IEA]
    apoptosis in response to endoplasmic reticulum stress [UNKNOWN][IEA]
    lymphoid progenitor cell differentiation [UNKNOWN][IEA]
    response to toxin [UNKNOWN][IEA]
    renal system process [UNKNOWN][IEA]
    T cell homeostasis [UNKNOWN][IEA]
    anti-apoptosis [UNKNOWN][IDA][IMP]
    ossification [UNKNOWN]
    apoptosis [UNKNOWN][IEP][TAS]
    defense response to virus [UNKNOWN][IEA]
    regulation of cell cycle [UNKNOWN][IEA]
    response to gamma radiation [UNKNOWN][IEA]
    focal adhesion assembly [UNKNOWN][IEA]
    B cell differentiation [UNKNOWN]
    cochlear nucleus development [UNKNOWN][IEA]
    regulation of protein localization [UNKNOWN][IEA]
    mesenchymal cell development [UNKNOWN][IEA]
    B cell proliferation [UNKNOWN][IEA]
    response to chemical stimulus [UNKNOWN]
    response to nutrient [IEP]
    regulation of apoptosis [UNKNOWN][IEA]
    response to peptide hormone stimulus [IEP]
    organ morphogenesis [UNKNOWN][IEA]
    T cell differentiation [UNKNOWN]
    oxygen and reactive oxygen species metabolic process [UNKNOWN][IEA]
    B cell lineage commitment [UNKNOWN][IEA]
    negative regulation of retinal cell programmed cell death [UNKNOWN][IEA]
    regulation of gene expression [UNKNOWN][IEA]
    regulation of nitrogen utilization [UNKNOWN][IEA]
    peptidyl-serine phosphorylation [UNKNOWN]
    response to UV-B [UNKNOWN][IEA]
    cell growth [UNKNOWN]
    peptidyl-threonine phosphorylation [UNKNOWN][IEA]
    negative regulation of cell migration [UNKNOWN][IEA]
    negative regulation of osteoblast proliferation [UNKNOWN][IEA]
    response to cytokine stimulus [UNKNOWN][IEP]
    response to aluminum ion [IEP]
    melanin metabolic process [UNKNOWN][IEA]
    lymphocyte homeostasis [UNKNOWN]
    response to cAMP [IEP]
    regulation of viral genome replication [IEA]
    response to oxidative stress [UNKNOWN][IEA]
    response to ethanol [IEP]
    developmental pigmentation [UNKNOWN]
    response to external stimulus [UNKNOWN][IEA]
    response to insulin stimulus [IEP]
    regulation of glycoprotein biosynthetic process [UNKNOWN][IEA]
    G1/S transition of mitotic cell cycle [UNKNOWN][IEA]
    response to iron ion [UNKNOWN][IEA]
    positive regulation of smooth muscle cell migration [UNKNOWN][IEA]
    response to inorganic substance [IEP]
    endoplasmic reticulum calcium ion homeostasis [UNKNOWN][IEA]
    negative regulation of myeloid cell apoptosis [UNKNOWN][IEA]
    protein amino acid dephosphorylation [UNKNOWN][IEA]
    response to copper ion [IEP]
    developmental growth [UNKNOWN][IEA]
    positive regulation of skeletal muscle fiber development [UNKNOWN][IEA]
    aging [IEP]
    positive regulation of melanocyte differentiation [UNKNOWN][IEA]
    cell aging [UNKNOWN][IEA]
    cellular calcium ion homeostasis [UNKNOWN]
    response to acid [UNKNOWN]
    melanocyte differentiation [UNKNOWN]
    regulation of protein stability [UNKNOWN][IEA]
    oocyte development [UNKNOWN][IEA]
    pigment granule organization [UNKNOWN][IEA]
    homeostasis of number of cells within a tissue [UNKNOWN][IEA]
    response to drug [UNKNOWN][IEP]
    negative regulation of apoptosis [UNKNOWN]
    ear development [UNKNOWN][IEA]
    response to folic acid [IEP]
    regulation of developmental pigmentation [UNKNOWN]
    response to caffeine [IEP]
    negative regulation of ossification [UNKNOWN][IEA]
    Molecular Function: BH domain binding [IPI]
    BH3 domain binding [UNKNOWN][IEA]
    identical protein binding [UNKNOWN]
    protein binding [UNKNOWN][IPI]
    protein homodimerization activity [UNKNOWN][IEA]
    protein heterodimerization activity [UNKNOWN][IPI]
    protease binding [UNKNOWN][IEA]
    sequence-specific DNA binding [UNKNOWN]
    transcription factor binding [UNKNOWN][IEA]
    transcription activator activity [UNKNOWN][IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAQAGRTGYD NREIVMKYIH YKLSQRGYEW DTGDEDSAPL RAAPTPGIFS FQPESNRTPA  60
   61 VHRDTAARTS PLRPLVANAG PALSPVPPVV HLTLRRAGDD FSRRYRRDFA EMSSQLHLTP 120
  121 FTARGRFATV VEELFRDGVN WGRIVAFFEF GGVMCVESVN REMSPLVDNI ALWMTEYLNR 180
  181 HLHTWIQDNG GWDAFVELYG PSMRPLFDFS WLSLKTLLSL ALVGACITLG AYLGHK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle