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A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor. The process whereby a precursor cell type acquires the specialized features of a T cell via a differentiation pathway dependent upon transit through the thymus. The process whereby a precursor cell type acquires the specialized features of a T cell via a differentiation pathway independent of the thymus. The process whereby a relatively unspecialized hemopoietic cell acquires specialized features of a gamma-delta T cell. The process whereby a precursor cell type acquires the specialized features of an alpha-beta T cell. The process whereby a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a plasmacytoid dendritic cell or any cell of the myeloid leukocyte or lymphocyte lineages. The somatic process by means of which sequence diversity of T cell receptor genes is generated. The process by which T cells that express T cell receptors that are restricted by self MHC protein complexes and tolerant to self antigens are selected for further maturation. The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. The process whereby a relatively unspecialized T cell acquires specialized features of a cytotoxic T cell. The process by which a relatively unspecialized T cell acquires specialized features of a regulatory T cell. Regulatory T cells control or suppress immune responses through a variety of mechanisms and subsets include the CD4+CD25+ cell type as well as certain CD8+ cell types. The process whereby a precursor cell type acquires the specialized features of a pro-T cell. Pro-T cells are the earliest stage of the T cell lineage but are not fully committed. The process by which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex. The process whereby an antigenically nave T cell acquires the specialized features of an effector, regulatory, or memory T cell during an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells. Any process that modulates the frequency, rate or extent of T cell differentiation. The process whereby a relatively unspecialized precursor cell acquires specialized features of B cells, T cells, or natural killer cells. Any process that stops, prevents or reduces the frequency, rate or extent of T cell differentiation. The process by which a lymphoid progenitor cell becomes committed to becoming any type of T cell. Any process that activates or increases the frequency, rate or extent of T cell differentiation.

View Gene Ontology (GO) Term

GO TERM SUMMARY

Name: T cell differentiation
Acc: GO:0030217
Aspect: Biological Process
Desc: The process by which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex.
Synonyms:
  • T cell development
  • T-lymphocyte differentiation
  • T lymphocyte differentiation
  • GO:0046652
  • GO:0042112
  • T-cell differentiation
  • T-cell development
Proteins in PDR annotated with:
   This term: 53 [Search]
   Term or descendants: 208 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0030217 - T cell differentiation (interactive image map)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle