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Protein Overview: Dscam-PL

General Information:
Name(s) found: Dscam-PL / FBpp0110381 [FlyBase]
Description(s) found:
Found 16 descriptions.
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  • The gene Down syndrome cell adhesion molecule is referred to in FlyBase by the symbol Dmel\Dscam (CG17800, FBgn0033159). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:3207059..3269374. It has the cytological map location 43A4-43B1. There is experimental evidence that it has the molecular function</span>: protein binding; bacterial binding; protein homodimerization activity; axon guidance receptor activity. There is experimental evidence that it is involved in the biological process</span>: dendrite self-avoidance; axon extension involved in axon guidance; axon guidance; phagocytosis; central nervous system morphogenesis; neuron development; axonal fasciculation; mushroom body development; peripheral nervous system development. 120 alleles are reported. The phenotypes of these alleles are annotated with 18 unique terms, many of which group under: nervous system; multi-cell-component structure; organ system; adult segment; embryonic nervous system; commissure; antennal segment; adult brain; peripheral nervous system; mushroom body. It has 59 annotated transcripts and 59 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 2031 amino acids

    Gene Ontology:
    Cellular Component: integral to plasma membrane [ISS]
    dendrite [IDA]
    neuronal cell body [IDA]
    axon [IDA]
    Biological Process: mushroom body development [IMP]
    dendrite self-avoidance [IDA][IMP]
    phagocytosis [IMP]
    axon guidance [IGI][IMP][TAS]
    peripheral nervous system development [IMP]
    neuron development [IMP]
    central nervous system morphogenesis [IMP]
    axonal fasciculation [IMP]
    axon extension involved in axon guidance [IMP]
    Molecular Function: protein binding [IDA]
    protein homodimerization activity [IPI]
    axon guidance receptor activity [IMP][NAS]
    bacterial cell surface binding [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNMPNERLKW LMLFAAVALI ACGSQTLAAN PPDADQKGPV FLKEPTNRID FSNSTGAEIE  60
   61 CKASGNPMPE IIWIRSDGTA VGDVPGLRQI SSDGKLVFPP FRAEDYRQEV HAQVYACLAR 120
  121 NQFGSIISRD VHVRAVVSQH YEEDIHKAFV IRGNSAILKC DIPSFVADFV NVISWHSDEK 180
  181 ENFYPGTEYD GKYLVLPSGE LHIREVGPED GYKSYQCRTK HRLTGETRLS ATKGRLVITE 240
  241 PVGSVAPKVD VKDRITWLDK PMGQALSLLC PAQSYPMPVY RWYKFIEGTT RKQAVVLNDR 300
  301 VKQVSGTLII KDAVVEDSGK YLCVVNNSVG GESVETVLTV TAPLSAKIDP PTQTVDFGRP 360
  361 AVFTCQYTGN PIKTVSWMKD GKAIGHSEPV LRIESVKKED KGMYQCFVRN DQESAEASAE 420
  421 LKLGGRFDPP VIRQAFQEET MEPGPSVFLK CVAGGNPTPE ISWELDGKKI ANNDRYQVGQ 480
  481 YVTVNGDVVS YLNITSVHAN DGGLYKCIAK SKVGVAEHSA KLNVYGLPYI RQMEKKAIVA 540
  541 GETLIVTCPV AGYPIDSIVW ERDNRALPIN RKQKVFPNGT LIIENVERNS DQATYTCVAK 600
  601 NQEGYSARGS LEVQVMVLPR IIPFAFEEGP AQVGQYLTLH CSVPGGDLPL NIDWTLDGQA 660
  661 ISEDLGITTS RVGRRGSVLT IEAVEASHAG NFTCHARNLA GHQQFTTPLN VYVPPRWILE 720
  721 PTDKAFAQGS DAKVECKADG FPKPQVTWKK AVGDTPGEYK DLKKSDNIRV EEGTLHVDNI 780
  781 QKTNEGYYLC EAINGIGSGL SAVIMISVQA PPEFTEKLRN QTARRGEPAV LQCEAKGEKP 840
  841 IGILWNMNNM RLDPKNDNRY TIREEILSTG VMSSLSIKRT ERSDSALFTC VATNAFGSDD 900
  901 ASINMIVQEV PEMPYALKVL DKSGRSVQLS WAQPYDGNSP LDRYIIEFKR SRASWSEIDR 960
  961 VIVPGHTTEA QVQKLSPATT YNIRIVAENA IGTSQSSEAV TIITAEEAPS GKPQNIKVEP1020
 1021 VNQTTMRVTW KPPPRTEWNG EILGYYVGYK LSNTNSSYVF ETINFITEEG KEHNLELQNL1080
 1081 RVYTQYSVVI QAFNKIGAGP LSEEEKQFTA EGTPSQPPSD TACTTLTSQT IRVGWVSPPL1140
 1141 ESANGVIKTY KVVYAPSDEW YDETKRHYKK TASSDTVLHG LKKYTNYTMQ VLATTAGGDG1200
 1201 VRSVPIHCQT EPDVPEAPTD VKALVMGNAA ILVSWRPPAQ PNGIITQYTV YSKAEGAETE1260
 1261 TKTQKVPHYQ MSFEATELEK NKPYEFWVTA STTIGEGQQS KSIVAMPSDQ VPAKIASFDD1320
 1321 TFTATFKEDA KMPCLAVGAP QPEITWKIKG VEFSANDRMR VLPDGSLLIK SVNRQDAGDY1380
 1381 SCHAENSIAK DSITHKLIVL APPQSPHVTL SATTTDALTV KLKPHEGDTA PLHGYTLHYK1440
 1441 PEFGEWETSE VSVDSQKHNI EGLLCGSRYQ VYATGFNNIG AGEASDILNT RTKGQKPKLP1500
 1501 EKPRFIEVSS NSVSLHFKAW KDGGCPMSHF VVESKKRDQI EWNQISNNVK PDNNYVVLDL1560
 1561 EPATWYNLRI TAHNSAGFTV AEYDFATLTV TGGTIAPLDD GSGHGNVHTR IRLPAWMPEW1620
 1621 LDLNFMVPLI ATVVVVAVGI CVVCVALSRR RADDMRGGQK DVYYDVVYNQ TMGPGATLDK1680
 1681 RRPDLRDELG YIAPPNRKLP PVPGSNYNTC DRIKRGRGGL RSNHSTWDPR RNPNLYEELK1740
 1741 APPVPMHGNH YGHAHGNAEC HYRHPGMEDE ICPYATFHLL GFREEMDPTK AMNFQTFPHQ1800
 1801 NGHAGPVPGH AGTMLPPGHP GHVHSRSGSQ SMPRANRYQR KNSQGGQSSI YTPAPEYDDP1860
 1861 ANCAEEDQYR RYTRVNSQGG SLYSGPGPEY DDPANCAPEE DQYGSQYGGP YGQPYDHYGS1920
 1921 RGSMGRRSIG SARNPGNGSP EPPPPPPRNH DMSNSSFNDS KESNEISEAE CDRDHGPRGN1980
 1981 YGAVKRSPQP KDQRTTEEMR KLIERNETGP KQLQLQQANG AGFTAYDTMA V

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..138] PSI-BLAST 78.69897 No description for 2v5sA was found.
    2 View Details [139..810] PSI-BLAST 56.045757 Model of human carcinoembryonic antigen by homology modelling and curve-fitting to experimental solution scattering data
    3 View Details [811..909] PSI-BLAST 36.69897 No description for 2nziA was found.
    4 View Details [910..1006] PSI-BLAST 12.221849 Solution Structure of The First Fibronectin Type III Domain of Human KIAA0343 protein
    5 View Details [1007..1102] PSI-BLAST 9.09691 Solution structure of the second FNIII domain of DSCAML1 protein
    6 View Details [1103..1213] PSI-BLAST 21.522879 Integin beta-4 subunit
    7 View Details [1214..1310] PSI-BLAST 10.0 The fourth FN3 domain of human sidekick-2
    8 View Details [1311..1656] PSI-BLAST 8.69897 Interleukin-6 receptor alpha chain, N-teminal domain; Interleukin-6 receptor alpha chain, domains 2 and 3
    9 View Details [1657..1854] deduced N/A No confident structure predictions are available.
    10 View Details [1855..2031] MSA 3.100993 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7
    Term Confidence Notes
  • pattern binding
    		•  0.31156427047296 bayes_pls_golite062009
    8 No functions predicted.
    9 No functions predicted.
    10 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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