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Protein Overview: Dscam-PS

General Information:
Name(s) found: Dscam-PS / FBpp0110388 [FlyBase]
Description(s) found:
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  • gi|116007646|ref|NP_001036519.1| down syndrome cell adhesion molecule, isoform S [Drosophila melanogaster] [NCBI NR]
  • gi|113194624|gb|ABI31070.1| down syndrome cell adhesion molecule, isoform S [Drosophila melanogaster] [NCBI NR]
  • The gene Down syndrome cell adhesion molecule is referred to in FlyBase by the symbol Dmel\Dscam (CG17800, FBgn0033159). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:3207059..3269374. It has the cytological map location 43A4-43B1. There is experimental evidence that it has the molecular function</span>: protein binding; bacterial binding; protein homodimerization activity; axon guidance receptor activity. There is experimental evidence that it is involved in the biological process</span>: dendrite self-avoidance; axon extension involved in axon guidance; axon guidance; phagocytosis; central nervous system morphogenesis; neuron development; axonal fasciculation; mushroom body development; peripheral nervous system development. 120 alleles are reported. The phenotypes of these alleles are annotated with 18 unique terms, many of which group under: nervous system; multi-cell-component structure; organ system; adult segment; embryonic nervous system; commissure; antennal segment; adult brain; peripheral nervous system; mushroom body. It has 59 annotated transcripts and 59 annotated polypeptides. [FlyBase]
  • type=protein; loc=2R:complement(3230139..3230386,3235354..3235515,3235636..3236480,3245096..3245219,3249223..3249372,3253448..3253609,3255893..3256237,3265039..3265099); ID=FBpp0110388; name=Dscam-PS; parent=FBgn0033159,FBtr0111093; dbxref=FlyBase:FBpp011 [fly-100309-contam.fasta]
  • Down syndrome cell adhesion molecule CG17800-PS, isoform S [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG17800-PS, isoform S [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=2R:complement(3230139..3230386,3235354..3235515,3235636..3236480,3245096..3245219,3249223..3249372,3253448..3253609,3255893..3256237,3265039..3265099); ID=FBpp0110388; name=Dscam-PS; parent=FBgn0033159,FBtr0111093; dbxref=FlyBase:FBpp0110388,FlyBase_Annotation_IDs:CG17800-PS,REFSEQ:NP_001036519,GB_protein:ABI31070; MD5=ad5dcadb697b0b4c4daf722a18ee3fd3; length=698; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=2R:complement(3230139..3230386,3235354..3235515,3235636..3236480,3245096..3245219,3249223..3249372,3253448..3253609,3255893..3256237,3265039..3265099); ID=FBpp0110388; name=Dscam-PS; parent=FBgn0033159,FBtr0111093; dbxref=FlyBase:FBpp0110388,FlyBase_Annotation_IDs:CG17800-PS,REFSEQ:NP_001036519,GB_protein:ABI31070; MD5=ad5dcadb697b0b4c4daf722a18ee3fd3; length=698; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • Down syndrome cell adhesion molecule, isoform S OS=Drosophila melanogaster GN=Dscam PE=4 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
    • Organism: Drosophila melanogaster
    Length: 698 amino acids

    Gene Ontology:
    Cellular Component: integral to plasma membrane [ISS]
    dendrite [IDA]
    neuronal cell body [IDA]
    axon [IDA]
    Biological Process: mushroom body development [IMP]
    dendrite self-avoidance [IDA][IMP]
    phagocytosis [IMP]
    axon guidance [IGI][IMP][TAS]
    peripheral nervous system development [IMP]
    neuron development [IMP]
    central nervous system morphogenesis [IMP]
    axonal fasciculation [IMP]
    axon extension involved in axon guidance [IMP]
    Molecular Function: protein binding [IDA]
    protein homodimerization activity [IPI]
    axon guidance receptor activity [IMP][NAS]
    bacterial cell surface binding [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNMPNERLKW LMLFAAVALI ACGSQTLAAN PPDADQKGPV FLKEPTNRID FSNSTGAEIE  60
   61 CKASGNPMPE IIWIRSDGTA VGDVPGLRQI SSDGKLVFPP FRAEDYRQEV HAQVYACLAR 120
  121 NQFGSIISRD VHVRAVVAQY YDTDVNKAYV IRGNAAVLKC EIPSFVADFV SVVSWHTDQN 180
  181 EDFLPGSEYD GKYLVLPSGE LHIREVGPED GYKSYQCRTK HRLTGETRLS ATKGRLVITE 240
  241 PVGSVAPKVD TRDEFTFART RMGASKALIC PAQSYPMPFF RWYKFIEGTT RKQAVVLNDR 300
  301 VKQVSGTLII KDAVVEDSGK YLCVVNNSVG GESVETVLTV TAPLSAKIDP PTQTVDFGRP 360
  361 AVFTCQYTGN PIKTVSWMKD GKAIGHSEPV LRIESVKKED KGMYQCFVRN DQESAEASAE 420
  421 LKLGGRFDPP VIRQAFQEET MEPGPSVFLK CVAGGNPTPE ISWELDGKKI ANNDRYQVGQ 480
  481 YVTVNGDVVS YLNITSVHAN DGGLYKCIAK SKVGVAEHSA KLNVYGLPYI RQMEKKAIVA 540
  541 GETLIVTCPV AGYPIDSIVW ERDNRALPIN RKQKVFPNGT LIIENVERNS DQATYTCVAK 600
  601 NQEGYSARGS LEVQVMVLPQ IVPFAYEDLI NMGDSIDLFC QIQKGDRPIK VHWSFERSAG 660
  661 DYGFDQVQPQ MRTNRISEKT SMISIPSASP AHTGRIPV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..426] PSI-BLAST 92.30103 No description for 2v5sA was found.
    2 View Details [427..698] PSI-BLAST 31.69897 No description for 2nziA was found.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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