YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: CASP3_MOUSE

General Information:
Name(s) found: CASP3_MOUSE [Swiss-Prot]
Description(s) found:
Found 35 descriptions.
SHOW ALL
  • Caspase-3 OS=Mus musculus GN=Casp3 PE=1 SV=1 [Swiss-Prot]
    • Organism: Mus musculus
    Length: 277 amino acids

    Gene Ontology:
    Cellular Component: soluble fraction [UNKNOWN]
    cytoplasm [IDA]
    cytosol [UNKNOWN]
    Biological Process: negative regulation of cell cycle [IMP]
    response to wounding [IDA]
    response to UV [IDA][IGI]
    induction of apoptosis via death domain receptors [IMP]
    positive regulation of neuron apoptosis [UNKNOWN]
    T cell homeostasis [IMP]
    learning or memory [UNKNOWN]
    sensory perception of sound [IMP]
    heart development [IGI]
    response to glucose stimulus [UNKNOWN]
    negative regulation of B cell proliferation [IMP]
    induction of apoptosis [IDA][IGI][IMP][RCA]
    apoptosis [UNKNOWN][IDA][IGI][IMP]
    neuron apoptosis [IDA]
    induction of apoptosis by oxidative stress [IDA]
    negative regulation of activated T cell proliferation [IMP]
    response to hydrogen peroxide [UNKNOWN]
    response to DNA damage stimulus [IDA]
    negative regulation of cyclin-dependent protein kinase activity [IMP]
    B cell homeostasis [IMP]
    keratinocyte differentiation [IMP]
    intracellular signaling pathway [UNKNOWN]
    DNA fragmentation involved in apoptosis [IMP]
    negative regulation of apoptosis [UNKNOWN]
    proteolysis [UNKNOWN][RCA]
    cell fate commitment [IMP]
    positive regulation of apoptosis [UNKNOWN]
    release of cytochrome c from mitochondria [IGI]
    Molecular Function: protein binding [IPI]
    cysteine-type endopeptidase activity [IEA]
    cysteine-type peptidase activity [UNKNOWN][IDA]
    peptidase activity [UNKNOWN][IDA][IMP][RCA]
    cyclin-dependent protein kinase inhibitor activity [IMP]
    phospholipase A2 activator activity [UNKNOWN]
    hydrolase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MENNKTSVDS KSINNFEVKT IHGSKSVDSG IYLDSSYKMD YPEMGICIII NNKNFHKSTG  60
   61 MSSRSGTDVD AANLRETFMG LKYQVRNKND LTREDILELM DSVSKEDHSK RSSFVCVILS 120
  121 HGDEGVIYGT NGPVELKKLT SFFRGDYCRS LTGKPKLFII QACRGTELDC GIETDSGTDE 180
  181 EMACQKIPVE ADFLYAYSTA PGYYSWRNSK DGSWFIQSLC SMLKLYAHKL EFMHILTRVN 240
  241 RKVATEFESF SLDSTFHAKK QIPCIVSMLT KELYFYH

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..277] PSI-BLAST 102.0 Apopain (caspase-3, cpp32)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • peptidase activity
    		•  3.24815349282067 bayes_pls_golite062009
  • protein binding
    		•  2.96725373477762 bayes_pls_golite062009
  • binding
    		•  2.91261616137775 bayes_pls_golite062009
  • cyclin-dependent protein kinase regulator activity
    		•  2.60103365510479 bayes_pls_golite062009
  • hydrolase activity
    		•  2.45602706385958 bayes_pls_golite062009
  • cysteine-type peptidase activity
    		•  2.37850336421322 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  2.07426831021634 bayes_pls_golite062009
  • cysteine-type endopeptidase activity
    		•  1.82979469421101 bayes_pls_golite062009
  • endopeptidase activity
    		•  1.58137850574981 bayes_pls_golite062009
  • cyclin-dependent protein kinase inhibitor activity
    		•  1.38256499817012 bayes_pls_golite062009
  • catalytic activity
    		•  1.03907950272772 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.0737251792690711 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle