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View Structure Prediction Details

Protein: CASP3_MOUSE
Organism: Mus musculus
Length: 277 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CASP3_MOUSE.

Description E-value Query
Range		 Subject
Range
gi|2137063 - gi|2137063|pir||S64710 cysteine proteinase (EC 3.4.22.-) CPP32 - Chinese hamster
 377.0 [0..1] [277..1]
CASP3_CRILO, ICE... - (Q60431) Caspase-3 precursor (EC 3.4.22.-) (CASP-3) (Apopain) (Cysteine protease CPP32) (Yama protei...
gi|1244444 - gi|1244444|gb|AAB01511.1| CPP-32 gene product
CASP3_MESAU - Caspase-3 OS=Mesocricetus auratus GN=CASP3 PE=2 SV=1
 377.0 [0..1] [277..1]
CASP3_RABIT - Caspase-3 OS=Oryctolagus cuniculus GN=CASP3 PE=2 SV=1
 373.0 [0..1] [277..1]
CASP3_RAT - Caspase-3 OS=Rattus norvegicus GN=Casp3 PE=2 SV=2
 371.0 [0..1] [277..1]
gi|30585109, gi|... - gi|61369707|gb|AAX43378.1| caspase 3 [synthetic construct], gi|30585109|gb|AAP36827.1| Homo sapiens ...
 370.0 [0..1] [277..1]
gi|123981280, gi... - gi|123996111|gb|ABM85657.1| caspase 3, apoptosis-related cysteine peptidase [synthetic construct], g...
CASP3 - caspase 3, apoptosis-related cysteine peptidase
 370.0 [0..1] [277..1]
CASP3_FELCA - Caspase-3 OS=Felis catus GN=CASP3 PE=2 SV=1
 369.0 [0..1] [277..1]
CASP3_PANTR - Caspase-3 OS=Pan troglodytes GN=CASP3 PE=2 SV=1
 369.0 [0..1] [277..1]

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Predicted Domain #1
Region A:
Residues: [1-277] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MENNKTSVDS KSINNFEVKT IHGSKSVDSG IYLDSSYKMD YPEMGICIII NNKNFHKSTG  60
   61 MSSRSGTDVD AANLRETFMG LKYQVRNKND LTREDILELM DSVSKEDHSK RSSFVCVILS 120
  121 HGDEGVIYGT NGPVELKKLT SFFRGDYCRS LTGKPKLFII QACRGTELDC GIETDSGTDE 180
  181 EMACQKIPVE ADFLYAYSTA PGYYSWRNSK DGSWFIQSLC SMLKLYAHKL EFMHILTRVN 240
  241 RKVATEFESF SLDSTFHAKK QIPCIVSMLT KELYFYH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 102.0
Match: 1cp3A
Description: Apopain (caspase-3, cpp32)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
peptidase activity 3.24815349282067 bayes_pls_golite062009
protein binding 2.96725373477762 bayes_pls_golite062009
binding 2.91261616137775 bayes_pls_golite062009
cyclin-dependent protein kinase regulator activity 2.60103365510479 bayes_pls_golite062009
hydrolase activity 2.45602706385958 bayes_pls_golite062009
cysteine-type peptidase activity 2.37850336421322 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 2.07426831021634 bayes_pls_golite062009
cysteine-type endopeptidase activity 1.82979469421101 bayes_pls_golite062009
endopeptidase activity 1.58137850574981 bayes_pls_golite062009
cyclin-dependent protein kinase inhibitor activity 1.38256499817012 bayes_pls_golite062009
catalytic activity 1.03907950272772 bayes_pls_golite062009
enzyme regulator activity 0.0737251792690711 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
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