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The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one. A process that is carried out at the cellular level which results in the disassembly of the nucleus and contributes to apoptosis. The nucleic acid metabolic process by which the phosphodiester bonds between nucleotides are cleaved by hydrolysis. Any cellular metabolic process involving nucleic acids. The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments. The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides. The breakdown of structures such as organelles, proteins, or other macromolecular structures during apoptosis.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: DNA fragmentation involved in apoptosis
Acc: GO:0006309
Aspect: Biological Process
Desc: The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments.
Synonyms:
  • endonucleolytic DNA catabolic process involved in apoptosis
  • DNA fragmentation
  • DNA catabolic process during apoptosis
  • DNA catabolism during apoptosis
  • GO:0008178
Proteins in PDR annotated with:
   This term: 44 [Search]
   Term or descendants: 44 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0006309 - DNA fragmentation involved in apoptosis (interactive image map)
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