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Protein Overview: ROX1

General Information:
Name(s) found: ROX1 / YPR065W [SGD]
Description(s) found:
Found 25 descriptions.
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  • Heme-dependent repressor of hypoxic genes; contains an HMG domain that is responsible for DNA bending activity [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 368 amino acids

    Gene Ontology:
    Cellular Component: nuclear chromosome [IPILink to PubMed article]
    Biological Process: negative regulation of transcription from RNA polymerase II promoter [IMPLink to PubMed article]
    Molecular Function: DNA bending activity [IDALink to PubMed article]
    specific transcriptional repressor activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNPKSSTPKI PRPKNAFILF RQHYHRILID EWTAQGVEIP HNSNISKIIG TKWKGLQPED  60
   61 KAHWENLAEK EKLEHERKYP EYKYKPVRKS KKKQLLLKEI EQQQQQQQKE QQQQKQSQPQ 120
  121 LQQPFNNNIV LMKRAHSLSP SSSVSSSNSY QFQLNNDLKR LPIPSVNTSN YMVSRSLSGL 180
  181 PLTHDKTARD LPQLSSQLNS IPYYSAPHDP STRHHYLNVA QAQPRANSTP QLPFISSIIN 240
  241 NSSQTPVTTT TTSTTTATSS PGKFSSSPNS SVLENNRLNS INNSNQYLPP PLLPSLQDFQ 300
  301 LDQYQQLKQM GPTYIVKPLS HTRNNLLSTT TPTHHHIPHI PNQNIPLHQI INSSNTEVTA 360
  361 KTSLVSPK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ESC1 ROX1 TAF2 TAF8

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data ROX1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..92] PSI-BLAST 86.228787 Sox-2
    2 View Details [93..368] MSA 15.354997 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • DNA binding
    		•  5.15324651287773 bayes_pls_golite062009
  • nucleic acid binding
    		•  5.01228762819617 bayes_pls_golite062009
  • transcription regulator activity
    		•  4.9607192917135 bayes_pls_golite062009
  • transcription factor activity
    		•  3.82658263870186 bayes_pls_golite062009
  • binding
    		•  3.6211482127468 bayes_pls_golite062009
  • transcription repressor activity
    		•  3.17018042329608 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.96229555092695 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.75319687398598 bayes_pls_golite062009
  • chromatin binding
    		•  1.64428658020027 bayes_pls_golite062009
  • transcription activator activity
    		•  1.62744929149746 bayes_pls_golite062009
  • protein binding
    		•  1.131658134984 bayes_pls_golite062009
  • transcription factor binding
    		•  1.10315330167937 bayes_pls_golite062009
  • DNA bending activity
    		•  0.87985209274756 bayes_pls_golite062009
  • specific transcriptional repressor activity
    		•  0.4255419067266 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity, enhancer binding
    		•  0.261169200304829 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle