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View Structure Prediction Details

Protein: ROX1
Organism: Saccharomyces cerevisiae
Length: 368 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ROX1.

Description E-value Query
Range
Subject
Range
gi|4336832 - gi|4336832|gb|AAD17974.1| SOX9 [Alligator mississippiensis]
3.0E-63 [3..348] [98..483]
gi|14581669, gi|... - gi|147899922|ref|NP_001084276.1| transcription factor SOX9 [Xenopus laevis], gi|14581669|gb|AAK61366...
3.0E-63 [3..348] [98..465]
gi|2826523 - gi|2826523|gb|AAB99738.1| putative transcription factor; SOX10 [Mus musculus]
1.0E-62 [4..348] [214..570]
gi|185134049, gi... - gi|185134049|ref|NP_001117742.1| SOX9 alpha2 [Oncorhynchus mykiss], gi|12003242|gb|AAG43497.1|AF2098...
6.0E-62 [1..348] [98..478]
gi|7707826 - gi|7707826|dbj|BAA95427.1| sox9 alpha [Rana rugosa]
5.0E-61 [3..348] [98..470]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
8.0E-61 [3..347] [98..494]
gi|11526785|gb|A... - Sox9 [Eublepharis macularius]
gi|11526785 - gi|11526785|gb|AAG36779.1| Sox9 [Eublepharis macularius]
2.0E-60 [3..348] [94..478]

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Predicted Domain #1
Region A:
Residues: [1-92]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNPKSSTPKI PRPKNAFILF RQHYHRILID EWTAQGVEIP HNSNISKIIG TKWKGLQPED  60
   61 KAHWENLAEK EKLEHERKYP EYKYKPVRKS KK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 86.228787
Match: 1gt0D_
Description: Sox-2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
DNA binding 5.15324651287773 bayes_pls_golite062009
nucleic acid binding 5.01228762819617 bayes_pls_golite062009
transcription regulator activity 4.9607192917135 bayes_pls_golite062009
transcription factor activity 3.82658263870186 bayes_pls_golite062009
binding 3.6211482127468 bayes_pls_golite062009
transcription repressor activity 3.17018042329608 bayes_pls_golite062009
sequence-specific DNA binding 2.96229555092695 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.75319687398598 bayes_pls_golite062009
chromatin binding 1.64428658020027 bayes_pls_golite062009
transcription activator activity 1.62744929149746 bayes_pls_golite062009
protein binding 1.131658134984 bayes_pls_golite062009
transcription factor binding 1.10315330167937 bayes_pls_golite062009
DNA bending activity 0.87985209274756 bayes_pls_golite062009
specific transcriptional repressor activity 0.4255419067266 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 0.261169200304829 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [93-368]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KQLLLKEIEQ QQQQQQKEQQ QQKQSQPQLQ QPFNNNIVLM KRAHSLSPSS SVSSSNSYQF  60
   61 QLNNDLKRLP IPSVNTSNYM VSRSLSGLPL THDKTARDLP QLSSQLNSIP YYSAPHDPST 120
  121 RHHYLNVAQA QPRANSTPQL PFISSIINNS SQTPVTTTTT STTTATSSPG KFSSSPNSSV 180
  181 LENNRLNSIN NSNQYLPPPL LPSLQDFQLD QYQQLKQMGP TYIVKPLSHT RNNLLSTTTP 240
  241 THHHIPHIPN QNIPLHQIIN SSNTEVTAKT SLVSPK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle