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Protein Overview: GIP3

General Information:
Name(s) found: GIP3 / YPL137C [SGD]
Description(s) found:
Found 26 descriptions.
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  • Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; may interact with ribosomes, based on co-purification experiments [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1276 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    endoplasmic reticulum [IDALink to PubMed article]
    ribosome [IDALink to PubMed article]
    Biological Process: chromosome segregation [IMPLink to PubMed article]
    regulation of phosphoprotein phosphatase activity [IMPLink to PubMed article]
    Molecular Function: protein phosphatase type 1 regulator activity [IMPLink to PubMed article]
    protein phosphatase 1 binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MITNTEFDVP VDWLYKGKSR RKTNTKPSRP STSPASSSST SSSKNGDNST SGNRSSNDKP  60
   61 RARSSSVSNA ALCNTEKPDL KRNDGNTSAS DTDNIPLLTP INSGNRSDSA DIDNPATVDA 120
  121 IDLIDNDDNG SSTQFVRKKR STSISNAVVS SKPRLASSAI NATASSSVGK GKHPPISSPS 180
  181 NATLKRSNST SGEKTKRSIF GSLFSKRSTS SSASTAKKPL PVVNTSTTEN ESGGIKAVAT 240
  241 PDPRVKEISS PMRGVAPTAS KPQTPILPSP ALAVKDLSTV SLKRVSFAVD KFESDPPQQL 300
  301 PSRTPKKGNI LIPDDMISEV PSISVGISSS NQSAKSTNSN IKGPLYTKKS KEYILALENQ 360
  361 KLALREAAKH QQEAHFAANR IAFEVANFKT ASDAGGKLTE KSSEGTITKQ REEVSPPNVE 420
  421 ADRELENNKL AENLSKAGID KPIHMHEHYF KEPDQDKYQD GHSIENNEVT LDVIYTRCCH 480
  481 LREILPIPST LRQVKDKTAP LQILKFLNPK PTLIDILSFC DFITIAPIHT IVFDNVALNQ 540
  541 DMFRIIISAL VNSTVLDKLS LRNVRIDQDG WKLLCKFLLL NKSLNKLDIS QTKIKSDLAE 600
  601 SLYRHNMDWN LFTDVLSQRS HKPIEELLFN GIQFSKIPYS CFARLLTSFA TQKNFPESGI 660
  661 RLGLAGATTS NISQDCLKFI FNWMSQYNVQ GVDLAFNDLS TMIKPMVGKL SALSYDNLRY 720
  721 FILNSTNIST SYDLALLLKY LSKLPNLIFL DLSNLSQCFP DILPYMYKYL PRFPNLKRIH 780
  781 LDSNNLTLKE LAVVCNILIK CKSLSHVSMT NQNVENFYLM NGTDSPVQQT NTDGDLDSSS 840
  841 TLDVKGQFAK NSFSSTLYAF ARDSPNLIGL DFDYDLISEE IQSRIALCLM RNMKRTMDST 900
  901 FQLDELDSQD DLLFDGSLVT MTAESVLEKL NLLSDKSTKV KKDTTKRYLL KKYIEKFHIL 960
  961 HHNVQHTIDT MFEKRKSGEL PLQEKENLVR LLLLEQNLCN ILELFSHNPN LNDVLGSSRD1020
 1021 DSKESVDSSE DSKLPALKHV ESGYHVPEEK IQPENDVITA RPHLMATDSG KTIDVFTGKP1080
 1081 LVFKHTSSST SVGCKKQEEE EGELHKWGFF VQQQRSLYPE NESTRQTPFA SGDTPINTET1140
 1141 AGKSTSSPSV STSNNETATT SLFSPANPKI LPKIPSGAVL RSAIMKAKGI DSIDDLIQNV1200
 1201 NSNNIELENI YGESIQNSAS TFTPGVDSDV SAPNTDKGSV ETLPAVSTDD PNCEVKVTAT1260
 1261 YDKLLNNLSM ERSIRL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) BNI4 BUD14 GIP3 GLC7 GLC8 HER1 PPZ1 PUF3 SDS22 SOL1 SOL2 YLR257W YPI1
    View Details Qiu et al. (2008) GIP1 GIP3 GIP4

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen RGD2 GIP3 2 Unpublished Fields Lab Data
    View Screen MCA1 GIP3 2 Unpublished Fields Lab Data
    View Screen IMD1 GIP3 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data GIP3 Huh WK, et al. (2003)
    View Data GIP3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..498] MSA 94.901997 View MSA. No confident structure predictions are available.
    2 View Details [499..592] PSI-BLAST 21.0 Ribonuclease inhibitor
    3 View Details [593..644] PSI-BLAST 21.0 Ribonuclease inhibitor
    4 View Details [645..701] PSI-BLAST 21.0 Ribonuclease inhibitor
    5 View Details [702..917] PSI-BLAST 21.0 Ribonuclease inhibitor
    6 View Details [918..1119] MSA 19.923995 View MSA. No confident structure predictions are available.
    7 View Details [1120..1276] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle