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Protein Overview: VPS28

General Information:
Name(s) found: VPS28 / YPL065W [SGD]
Description(s) found:
Found 27 descriptions.
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  • Component of the ESCRT-I complex (Stp22p, Srn2p, Vps28p, and Mvb12p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 242 amino acids

    Gene Ontology:
    Cellular Component: endosome [IDALink to PubMed article]
    ESCRT I complex [IDALink to PubMed article][IPILink to PubMed articleLink to PubMed article]
    Biological Process: ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [ICLink to PubMed article]
    telomere maintenance [IMPLink to PubMed articleLink to PubMed article]
    protein targeting to membrane [IMPLink to PubMed article][IPILink to PubMed article]
    protein targeting to vacuole [IMPLink to PubMed article][IPILink to PubMed article]
    Molecular Function: protein binding [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQKHNIKLNQ NQDISQLFHD EVPLFDNSIT SKDKEVIETL SEIYSIVITL DHVEKAYLKD  60
   61 SIDDTQYTNT VDKLLKQFKV YLNSQNKEEI NKHFQSIEAF CDTYNITASN AITRLERGIP 120
  121 ITAEHAISTT TSAPSGDNKQ SSSSDKKFNA KYVAEATGNF ITVMDALKLN YNAKDQLHPL 180
  181 LAELLISINR VTRDDFENRS KLIDWIVRIN KLSIGDTLTE TQIRELLFDL ELAYKSFYAL 240
  241 LD

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) MVB12 SRN2 STP22 VPS28
    View Details Qiu et al. (2008) DID4 MVB12 SNF7 SRN2 STP22 VPS24 VPS25 VPS28

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data VPS28 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..242] MSA 1.01497 View MSA. No confident structure predictions are available.
    2 View Details [148..242] PSI-BLAST 38.0 No description for 2j9vA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  1.84486828479515 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle