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Protein Overview: MVB12

General Information:
Name(s) found: MVB12 / YGR206W [SGD]
Description(s) found:
Found 30 descriptions.
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  • ESCRT-I subunit required to stabilize oligomers of the ESCRT-I core complex (Stp22p, Vps28p, Srn2p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; deletion mutant is sensitive to rapamycin and nystatin [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 101 amino acids

    Gene Ontology:
    Cellular Component: endosome [IDALink to PubMed articleLink to PubMed article]
    ESCRT I complex [IDALink to PubMed article][IPILink to PubMed article]
    Biological Process: protein targeting to vacuole [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNNNVEELLR RIPLYNKYGK DFPQETVTRF QMPEFKLPAL QPTRDLLCPW YEECDNITKV  60
   61 CQLHDSSNKK FDQWYKEQYL SKKPPGIVGN TLLSPSRKDN S

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) MVB12 SRN2 STP22
    View Details Krogan NJ, et al. (2006) MVB12 SRN2 STP22 VPS28
    View Details Qiu et al. (2008) DID4 MVB12 SNF7 SRN2 VPS28

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data MVB12 Huh WK, et al. (2003)
    View Data MVB12 and SNF7 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..101] PSI-BLAST 42.39794 No description for 2p22D was found.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle