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Protein Overview: ROD1

General Information:
Name(s) found: ROD1 / YOR018W [SGD]
Description(s) found:
Found 27 descriptions.
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  • Membrane protein that binds the ubiquitin ligase Rsp5p via its 2 PY motifs; overexpression confers resistance to the GST substrate o-dinitrobenzene,zinc, and calcium; proposed to regulate the endocytosis of plasma membrane proteins [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 837 amino acids

    Gene Ontology:
    Cellular Component: plasma membrane [IDALink to PubMed article]
    Biological Process: response to drug [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFSSSSRPSK EPLLFDIRLR NLDNDVLLIK GPPDEASSVL LSGTIVLSIT EPIQIKSLAL  60
   61 RLFGRLRLNI PTVLQTVHGP HKRYSKFERN IYSHFWDDFN IKSYFQNLYD NHNNGKITIS 120
  121 SKSSTNLAAL PKRKRALSTA SLISSNGQTS ASKNYHTLVK GNYEFPFSAI IPGSLVESVE 180
  181 GLPNAAVTYA LEATIERPKQ PDLICKKHLR VIRTLAIDAV ELSETVSVDN SWPEKVDYTI 240
  241 SIPTKAIAIG SSTMINILIV PILKGLKLGP VRISLVENSQ YCGSYGGVIN QERMVAKLKL 300
  301 KDPLKHVAQI KKKRSLNEAA DEGVDTDTGE FQDKWEVRAL LNIPASLTKC SQDCRILSNI 360
  361 KVRHKIKFTI SLLNPDGHIS ELRAALPVQL FISPFVPVNV KTSDVIERTL KTFGPSYQVT 420
  421 SQHDNSFSSK NFVDDSEEDV IFQRSASALQ LSSMPTIVSG STLNINSTDA EATAVADTTM 480
  481 VTSLMVPPNY GNHVYDRVYG EVTNEDETSA SASSSAVESQ AIHNIQNLYI SDSNNSNNPI 540
  541 LAPNPQIKIE DDSLNNCDSR GDSVNNSNLN LVNSNLTISE NWNNNSPSAN RYNNIINAGL 600
  601 NSPSLTPSFA HLSRRNSYSR QTSSTSLKND LELTDLSRVP SYDKAMKSDM IGEDLPPAYP 660
  661 EEELGVQENK KIELERPQIL HHKSTSSLLP LPGSSKSSNN LKRSSSRTHL SHSPLPRNNS 720
  721 GSSVSLQQLA RNNTDSSFNL NLSFTSAKSS TGSRHFPFNM TTSFTSNSSS KNNSHFDKTD 780
  781 STSDANKPRE EENYTSATHN RRSRSSSVRS NNSNSPLRQG TGSFANLMEM FTKRDRS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) BIO3 CIR1 NEJ1 ROD1 SOL4
    View Details Ho Y, et al. (2002) FUS3 GPH1 HOG1 HRK1 IDH2 PST2 RCK1 ROD1 RPN8 SIP1 SNF1 SNF4

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #19 Asynchronous Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #19b Asynchronous Prep1-new search criteria Keck JM, et al. (2011)
    View Run MLP2 #19a Asynchronous Prep1-new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen TSR4 ROD1 2 Unpublished Fields Lab Data
    View Screen RRB1 ROD1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data ROD1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..122] MSA 2.056996 View MSA. No confident structure predictions are available.
    2 View Details [123..200]
    [277..292]
    [319..363]    		 PSI-BLAST 70.0 Arrestin
    3 View Details [201..276]
    [293..318]
    [364..416]    		 PSI-BLAST 70.0 Arrestin
    4 View Details [417..673]
    [724..767]    		 ORFEUS 7.47 Baseplate structural protein gp27
    5 View Details [674..723]
    [768..837]    		 ORFEUS 7.47 Baseplate structural protein gp27

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • ligand-gated channel activity
    		•  1.70521304005804 bayes_pls_golite062009
  • ligand-gated ion channel activity
    		•  1.70521304005804 bayes_pls_golite062009
  • binding
    		•  1.4616591463066 bayes_pls_golite062009
  • cation channel activity
    		•  1.3614234284962 bayes_pls_golite062009
  • transporter activity
    		•  1.30471301990067 bayes_pls_golite062009
  • protein binding
    		•  1.2505002916716 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  1.20151630265738 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.19877351610468 bayes_pls_golite062009
  • gated channel activity
    		•  1.19663085813978 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  0.902444701590243 bayes_pls_golite062009
  • channel activity
    		•  0.902444701590243 bayes_pls_golite062009
  • ion channel activity
    		•  0.856063376717602 bayes_pls_golite062009
  • potassium channel activity
    		•  0.790846874610763 bayes_pls_golite062009
  • voltage-gated cation channel activity
    		•  0.632546300715335 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  0.609908998221517 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  0.585778587023806 bayes_pls_golite062009
  • voltage-gated potassium channel activity
    		•  0.576753448002164 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  0.538163997788255 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.349685182473293 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.289382545119226 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.201132556494603 bayes_pls_golite062009
  • inward rectifier potassium channel activity
    		•  0.0874939983339416 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle