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Protein Overview: HRD3

General Information:
Name(s) found: HRD3 / YLR207W [SGD]
Description(s) found:
Found 23 descriptions.
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  • Resident protein of the ER membrane that plays a central role in ER-associated protein degradation (ERAD), forms HRD complex with Hrd1p and ERAD determinants that engages in lumen to cytosol communication and coordination of ERAD events [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 833 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum membrane [IPILink to PubMed article]
    Biological Process: ER-associated protein catabolic process [IDALink to PubMed article]
    Molecular Function: ubiquitin-protein ligase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MITLLLYLCV ICNAIVLIRA DSIADPWPEA RHLLNTIAKS RDPMKEAAME PNADEFVGFY  60
   61 VPMDYSPRNE EKNYQSIWQN EITDSQRHIY ELLVQSSEQF NNSEATYTLS QIHLWSQYNF 120
  121 PHNMTLAHKY LEKFNDLTHF TNHSAIFDLA VMYATGGCAS GNDQTVIPQD SAKALLYYQR 180
  181 AAQLGNLKAK QVLAYKYYSG FNVPRNFHKS LVLYRDIAEQ LRKSYSRDEW DIVFPYWESY 240
  241 NVRISDFESG LLGKGLNSVP SSTVRKRTTR PDIGSPFIAQ VNGVQMTLQI EPMGRFAFNG 300
  301 NDGNINGDED DEDASERRII RIYYAALNDY KGTYSQSRNC ERAKNLLELT YKEFQPHVDN 360
  361 LDPLQVFYYV RCLQLLGHMY FTGEGSSKPN IHMAEEILTT SLEISRRAQG PIGRACIDLG 420
  421 LINQYITNNI SQAISYYMKA MKTQANNGIV EFQLSKLATS FPEEKIGDPF NLMETAYLNG 480
  481 FIPAIYEFAV MIESGMNSKS SVENTAYLFK TFVDKNEAIM APKLRTAFAA LINDRSEVAL 540
  541 WAYSQLAEQG YETAQVSAAY LMYQLPYEFE DPPRTTDQRK TLAISYYTRA FKQGNIDAGV 600
  601 VAGDIYFQMQ NYSKAMALYQ GAALKYSIQA IWNLGYMHEH GLGVNRDFHL AKRYYDQVSE 660
  661 HDHRFYLASK LSVLKLHLKS WLTWITREKV NYWKPSSPLN PNEDTQHSKT SWYKQLTKIL 720
  721 QRMRHKEDSD KAAEDSHKHR TVVQNGANHR GDDQEEASEI LGFQMEDLVT MGCILGIFLL 780
  781 SILMSTLAAR RGWNVRFNGA QLNANGNRQQ EQQQQQQAQG PPGWDFNVQI FAI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen RAD1 HRD3 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..169] ORFEUS 13.79 Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
    2 View Details [170..240] ORFEUS 13.79 Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
    3 View Details [241..352] ORFEUS 13.79 Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
    4 View Details [353..496] PSI-BLAST 10.39794 Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
    5 View Details [497..578] PSI-BLAST 10.39794 Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
    6 View Details [579..706] PSI-BLAST 10.39794 Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
    7 View Details [707..833] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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