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View Structure Prediction Details

Protein: HRD3
Organism: Saccharomyces cerevisiae
Length: 833 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HRD3.

Description E-value Query
Range
Subject
Range
HRD3 - Resident protein of the ER membrane that plays a central role in ER-associated protein degradation (...
HRD3_YEAST - ERAD-associated E3 ubiquitin-protein ligase component HRD3 OS=Saccharomyces cerevisiae (strain ATCC ...
0.0 [1..833] [1..833]
SEL1L - sel-1 suppressor of lin-12-like (C. elegans)
gi|225000728, gi... - gi|225000928|gb|AAI72577.1| Sel-1 suppressor of lin-12-like (C. elegans) [synthetic construct], gi|2...
2.0E-66 [51..728] [159..768]
SE1L1_MESAU - Protein sel-1 homolog 1 OS=Mesocricetus auratus GN=Sel1l PE=2 SV=1
3.0E-66 [51..728] [159..768]
SE1L1_MOUSE - Protein sel-1 homolog 1 OS=Mus musculus GN=Sel1l PE=1 SV=2
2.0E-65 [51..728] [155..764]
gi|14532716 - gi|14532716|gb|AAK64159.1| unknown protein [Arabidopsis thaliana]
1.0E-56 [139..679] [76..591]
gi|19074843, gi|... - gi|19074843|ref|NP_586349.1| similarity to SKT5 PROTEIN [Encephalitozoon cuniculi GB-M1], gi|1906956...
gi|19074843 - gi|19074843|ref|NP_586349.1| similarity to SKT5 PROTEIN [Encephalitozoon cuniculi GB-M1]
6.0E-51 [154..698] [14..563]

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Predicted Domain #1
Region A:
Residues: [1-169]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MITLLLYLCV ICNAIVLIRA DSIADPWPEA RHLLNTIAKS RDPMKEAAME PNADEFVGFY  60
   61 VPMDYSPRNE EKNYQSIWQN EITDSQRHIY ELLVQSSEQF NNSEATYTLS QIHLWSQYNF 120
  121 PHNMTLAHKY LEKFNDLTHF TNHSAIFDLA VMYATGGCAS GNDQTVIPQ

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 13.79
Match: 1fchA
Description: Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [170-240]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DSAKALLYYQ RAAQLGNLKA KQVLAYKYYS GFNVPRNFHK SLVLYRDIAE QLRKSYSRDE  60
   61 WDIVFPYWES Y

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 13.79
Match: 1fchA
Description: Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [241-352]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NVRISDFESG LLGKGLNSVP SSTVRKRTTR PDIGSPFIAQ VNGVQMTLQI EPMGRFAFNG  60
   61 NDGNINGDED DEDASERRII RIYYAALNDY KGTYSQSRNC ERAKNLLELT YK

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 13.79
Match: 1fchA
Description: Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [353-496]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EFQPHVDNLD PLQVFYYVRC LQLLGHMYFT GEGSSKPNIH MAEEILTTSL EISRRAQGPI  60
   61 GRACIDLGLI NQYITNNISQ AISYYMKAMK TQANNGIVEF QLSKLATSFP EEKIGDPFNL 120
  121 METAYLNGFI PAIYEFAVMI ESGM

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.39794
Match: 1fchA_
Description: Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [497-578]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NSKSSVENTA YLFKTFVDKN EAIMAPKLRT AFAALINDRS EVALWAYSQL AEQGYETAQV  60
   61 SAAYLMYQLP YEFEDPPRTT DQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.39794
Match: 1fchA_
Description: Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [579-706]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RKTLAISYYT RAFKQGNIDA GVVAGDIYFQ MQNYSKAMAL YQGAALKYSI QAIWNLGYMH  60
   61 EHGLGVNRDF HLAKRYYDQV SEHDHRFYLA SKLSVLKLHL KSWLTWITRE KVNYWKPSSP 120
  121 LNPNEDTQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.39794
Match: 1fchA_
Description: Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
Matching Structure (courtesy of the PDB):

Predicted Domain #7
Region A:
Residues: [707-833]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HSKTSWYKQL TKILQRMRHK EDSDKAAEDS HKHRTVVQNG ANHRGDDQEE ASEILGFQME  60
   61 DLVTMGCILG IFLLSILMST LAARRGWNVR FNGAQLNANG NRQQEQQQQQ QAQGPPGWDF 120
  121 NVQIFAI

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle