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Protein Overview: GET1

General Information:
Name(s) found: GET1 / YGL020C [SGD]
Description(s) found:
Found 31 descriptions.
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  • Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for normal mitochondrial morphology and inheritance [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 235 amino acids

    Gene Ontology:
    Cellular Component: GET complex [IPILink to PubMed article]
    mitochondrion [IDALink to PubMed article]
    endoplasmic reticulum [IDALink to PubMed article]
    Biological Process: retrograde vesicle-mediated transport, Golgi to ER [IDALink to PubMed article][IGILink to PubMed article][IMPLink to PubMed article]
    protein amino acid glycosylation [IMPLink to PubMed article]
    response to unfolded protein [IMPLink to PubMed article]
    mitochondrion organization [IMPLink to PubMed article]
    cellular calcium ion homeostasis [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHWAAAVAIF FIVVTKFLQY TNKYHEKWIS KFAPGNELSK KYLAKVKERH ELKEFNNSIS  60
   61 AQDNYAKWTK NNRKLDSLDK EINNLKDEIQ SENKAFQAHL HKLRLLALTV PFFVFKIMYG 120
  121 KTPVYKLSSS TSTLFPTFVS GVWSQGWLYV LLHPLRTISQ KWHIMEGKFG ASKFDDMALQ 180
  181 SVSLGIWVWA LMNVINGVEF IVKQLFLTPK MEAPASVETQ EEKALDAVDD AIILD

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) GET1 GET2 GET3
    View Details Krogan NJ, et al. (2006) GET1 GET2 GET3 PSK1 TAT1 YHP1
    View Details Ho Y, et al. (2002) GET1 GET2 GET3 GRX7 GSF2 POR1
    View Details Qiu et al. (2008) GET1 GET2 GET3

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data GET1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..235] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle