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Protein Overview: RPH1

General Information:
Name(s) found: RPH1 / YER169W [SGD]
Description(s) found:
Found 25 descriptions.
SHOW ALL
  • JmjC domain-containing histone demethylase which can specifically demethylate H3K36 tri- and dimethyl modification states; transcriptional repressor of PHR1; Rph1p phosphorylation during DNA damage is under control of the MEC1-RAD53 pathway [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 796 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ICLink to PubMed article]
    Biological Process: negative regulation of transcription from RNA polymerase II promoter [IDALink to PubMed article]
    DNA repair [IMPLink to PubMed article]
    Molecular Function: specific transcriptional repressor activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTKLIAPSEI VGGVPVFKPT YEQFEDFYAY CKAINKYGMK SGVVKVIPPK EWKDKLDLPY  60
   61 SAETLQKIKI KSPIQQHISG NKGLFMVQNV EKNKTYNIIQ WKDLSKDYVP PEDPKARRNS 120
  121 RKGSVSKSTK LKLKNFESSF NIDDFEQFRT EYTIDLSDFQ NTERLKFLEE YYWKTLNFTT 180
  181 PMYGADTPGS IFPEGLNVWN VAKLPNILDH METKVPGVND SYLYAGLWKA SFSWHLEDQD 240
  241 LYSINYIHFG APKQWYSIPQ EDRFKFYKFM QEQFPEEAKN CPEFLRHKMF LASPKLLQEN 300
  301 GIRCNEIVHH EGEFMITYPY GYHAGFNYGY NLAESVNFAL EEWLPIGKKA GKCHCISDSV 360
  361 EIDVKKLAKS WRDNNKESKG TPPLNQLPNP AMPLLHRPTL KEMESSSLRS TSPDVGHFSN 420
  421 FKSKSSGVSS PLLSRMKDYS NIVEPTLEDP TLKLKRISSF QEQPLNKLLK RETSQTAMLT 480
  481 DHEDNIVAMS LTSMANSAAS SPRLPLSRLN SSNELSNAQP LLDMTNNTLA FPRPNGPSGL 540
  541 NPLLYISNKN ISGISHSAPH SPVNPNISLI KRVKSPNIVT LNISRESSRS PIALNYEARQ 600
  601 QHSQQHSFST PSTVSNLSTS VLGPLSDTND IKTPHPERPN HKTANRILKK ESPVETSKSN 660
  661 LILSKVASTR QEDSFTSRND DLDKEQGSSP LNSKFAPEEI VLSGKNKIYI CKECQRKFSS 720
  721 GHHLTRHKKS VHSGEKPHSC PKCGKRFKRR DHVLQHLNKK IPCISNETTV DAPIMNPTVQ 780
  781 PQDGKAAINQ QSTPLN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RLF2 phosphorylation data - cascade search Green EM, et al (2005)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen NAS2 RPH1 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data RPH1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..59] Pfam 24.920819 jmjN domain No confident structure predictions are available.
    2 View Details [60..198] MSA 3.084997 View MSA. No confident structure predictions are available.
    3 View Details [199..378] Pfam 57.05061 JmjC domain No confident structure predictions are available.
    4 View Details [379..431] deduced N/A Confident ab initio structure predictions are available.
    5 View Details [432..587] PSI-BLAST 55.927757 Ying-yang 1 (yy1, zinc finger domain)
    6 View Details [588..676] MSA 8.174996 View MSA. No confident structure predictions are available.
    7 View Details [677..796] PSI-BLAST 94.9897 Designed zinc finger protein

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • transcription regulator activity
    		•  4.70988788192472 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.58713908116892 bayes_pls_golite062009
  • DNA binding
    		•  4.56219307357342 bayes_pls_golite062009
  • transcription factor activity
    		•  3.50954949535763 bayes_pls_golite062009
  • transcription repressor activity
    		•  3.27542149084008 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.22082323675675 bayes_pls_golite062009
  • binding
    		•  3.10743787485868 bayes_pls_golite062009
  • transcription activator activity
    		•  2.19952417915035 bayes_pls_golite062009
  • chromatin binding
    		•  2.18464662431232 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.63161912031789 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.42975942698743 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.42446448463712 bayes_pls_golite062009
  • transcription factor binding
    		•  1.39608963544799 bayes_pls_golite062009
  • transcription corepressor activity
    		•  1.34049786451995 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  1.1674904189309 bayes_pls_golite062009
  • protein binding
    		•  1.00484935878505 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.77874411480713 bayes_pls_golite062009
  • histone binding
    		•  0.687710658383448 bayes_pls_golite062009
  • catalytic activity
    		•  0.245893663605433 bayes_pls_golite062009
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle