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Protein Overview: INO2

General Information:
Name(s) found: INO2 / YDR123C [SGD]
Description(s) found:
Found 35 descriptions.
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  • Component of the heteromeric Ino2p/Ino4p basic helix-loop-helix transcription activator that binds inositol/choline-responsive elements (ICREs), required for derepression of phospholipid biosynthetic genes in response to inositol depletion [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 304 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    Biological Process: phospholipid biosynthetic process [IMPLink to PubMed article]
    positive regulation of transcription from RNA polymerase II promoter [IMPLink to PubMed article][IPILink to PubMed article]
    Molecular Function: specific RNA polymerase II transcription factor activity [IMPLink to PubMed article][IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQQATGNELL GILDLDNDID FETAYQMLSS NFDDQMSAHI HENTFSATSP PLLTHELGII  60
   61 PNVATVQPSH VETIPADNQT HHAPLHTHAH YLNHNPHQPS MGFDQALGLK LSPSSSGLLS 120
  121 TNESNAIEQF LDNLISQDMM SSNASMNSES HLHIRSPKKQ HRYTELNQRY PETHPHSNTG 180
  181 ELPTNTADVP TEFTTREGPH QPIGNDHYNP PPFSVPEIRI PDSDIPANIE DDPVKVRKWK 240
  241 HVQMEKIRRI NTKEAFERLI KSVRTPPKEN GKRIPKHILL TCVMNDIKSI RSANEALQHI 300
  301 LDDS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) INO2 INO4

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data INO2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..214] deduced N/A No confident structure predictions are available.
    2 View Details [215..304] Pfam 2.522879 Helix-loop-helix DNA-binding domain No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • transcription regulator activity
    		•  5.08855036296174 bayes_pls_golite062009
  • DNA binding
    		•  4.87243318281876 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.77537175825177 bayes_pls_golite062009
  • transcription factor activity
    		•  4.43134840465732 bayes_pls_golite062009
  • binding
    		•  3.63719401349018 bayes_pls_golite062009
  • transcription activator activity
    		•  3.62180682771335 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  3.17029130860224 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.11931609869373 bayes_pls_golite062009
  • protein binding
    		•  2.53793947976093 bayes_pls_golite062009
  • transcription factor binding
    		•  2.33137487648005 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity, enhancer binding
    		•  2.01283700957804 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.30186253699056 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.828519845330998 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.560586077390024 bayes_pls_golite062009
  • promoter binding
    		•  0.531949034115114 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.328788240668351 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.172100901723138 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.0815596840205237 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle