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View Structure Prediction Details

Protein: INO2
Organism: Saccharomyces cerevisiae
Length: 304 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for INO2.

Description E-value Query
Range
Subject
Range
INO2_YEAST - Protein INO2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=INO2 PE=1 SV=1
gi|190404915 - gi|190404915|gb|EDV08182.1| helix-loop-helix protein [Saccharomyces cerevisiae RM11-1a]
INO2 - Component of the heteromeric Ino2p/Ino4p basic helix-loop-helix transcription activator that binds i...
gi|207346707 - gi|207346707|gb|EDZ73125.1| YDR123Cp-like protein [Saccharomyces cerevisiae AWRI1631]
0.0 [1..304] [1..304]

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Predicted Domain #1
Region A:
Residues: [1-214]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQQATGNELL GILDLDNDID FETAYQMLSS NFDDQMSAHI HENTFSATSP PLLTHELGII  60
   61 PNVATVQPSH VETIPADNQT HHAPLHTHAH YLNHNPHQPS MGFDQALGLK LSPSSSGLLS 120
  121 TNESNAIEQF LDNLISQDMM SSNASMNSES HLHIRSPKKQ HRYTELNQRY PETHPHSNTG 180
  181 ELPTNTADVP TEFTTREGPH QPIGNDHYNP PPFS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [215-304]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VPEIRIPDSD IPANIEDDPV KVRKWKHVQM EKIRRINTKE AFERLIKSVR TPPKENGKRI  60
   61 PKHILLTCVM NDIKSIRSAN EALQHILDDS 

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 2.522879
Match: PF00010
Description: Helix-loop-helix DNA-binding domain

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.08855036296174 bayes_pls_golite062009
DNA binding 4.87243318281876 bayes_pls_golite062009
nucleic acid binding 4.77537175825177 bayes_pls_golite062009
transcription factor activity 4.43134840465732 bayes_pls_golite062009
binding 3.63719401349018 bayes_pls_golite062009
transcription activator activity 3.62180682771335 bayes_pls_golite062009
sequence-specific DNA binding 3.17029130860224 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.11931609869373 bayes_pls_golite062009
protein binding 2.53793947976093 bayes_pls_golite062009
transcription factor binding 2.33137487648005 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 2.01283700957804 bayes_pls_golite062009
transcription cofactor activity 1.30186253699056 bayes_pls_golite062009
transcription repressor activity 0.828519845330998 bayes_pls_golite062009
transcription corepressor activity 0.560586077390024 bayes_pls_golite062009
promoter binding 0.531949034115114 bayes_pls_golite062009
protein heterodimerization activity 0.328788240668351 bayes_pls_golite062009
transcription coactivator activity 0.172100901723138 bayes_pls_golite062009
protein dimerization activity 0.0815596840205237 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle