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Protein Overview: ggr-2

General Information:
Name(s) found: ggr-2 / CE39337 [WormBase]
Description(s) found:
Found 13 descriptions.
SHOW ALL
  • WBGene00001587 locus:ggr-2 status:Partially_confirmed UniProt:Q2WF65 protein_id:CCD63812.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 546 amino acids

    Gene Ontology:
    Cellular Component: postsynaptic membrane [IEALink to PubMed article]
    membrane [IEALink to PubMed article]
    integral to membrane [IEALink to PubMed article]
    Biological Process: ion transport [IEALink to PubMed article]
    taxis [IMP]
    transport [IEALink to PubMed article]
    Molecular Function: neurotransmitter receptor activity [IEALink to PubMed article]
    extracellular ligand-gated ion channel activity [IEALink to PubMed article]
    chloride channel activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLLVSSIFLL LYRNSPKVEA SRSEPVPIYL DNLLNAGRQV YDNQSPPVQH DKEEVTVVEL  60
   61 AMYIEGMSSF RTQTMDFQLD VYFQQFWRDP RLAHNETRRV LVKDKAVLHK MWKPDVYFAN 120
  121 ARIAEFHEVT QPNFLVWIQP DGSILYDTRI SMVVVCTLNL EKWPLDSQRC HLRILSYAYT 180
  181 TEQLVIKWKE DEPITRNPNI AMSDMHIVDL YPGLCDGNYS TGTWSCVTAE FFVKREITHH 240
  241 VMQSYVPTTL IVVISWFSFW LDVEAVPARV SLAITTLLTL STQANAARMA LPEVSYMKAI 300
  301 DVWMGACMMF VFGVMIEFTI VNYAQRQGRK WHRTDAEIVM ASSLESVKSG NAEKKPSRGD 360
  361 LGAHARHLFL RLRTNERQHL VEDPPEQIAM NDTAYDTVSQ AYSNSFSDEE AAPVVQPPQN 420
  421 EDAEAQEEVW AEQKETNLSE VWKESDPAER LAHWNEKEND ASSPLMGNGR AHVRYGAAEK 480
  481 MKNRKCNDSS RKKEKWSSAI KQIQKHKKIA GRNRAKKIDQ TSRWIFPLTF IIFNLTYWIY 540
  541 YLYWKE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..343] PSI-BLAST 69.30103 Refined structure of the nicotinic acetylcholine receptor at 4A resolution.
    2 View Details [344..463] PSI-BLAST 24.221849 Acetylcholine receptor protein, delta chain
    3 View Details [464..546] FFAS03 1.38 Acetylcholine receptor protein, delta chain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • ion transmembrane transporter activity
    		•  7.22265353460749 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  7.15153709132033 bayes_pls_golite062009
  • channel activity
    		•  7.15153709132033 bayes_pls_golite062009
  • ion channel activity
    		•  7.1489450300492 bayes_pls_golite062009
  • gated channel activity
    		•  7.07040350691167 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  7.06843378380114 bayes_pls_golite062009
  • cation channel activity
    		•  7.05528966701307 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  7.02602175506525 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  6.7875346065164 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  6.75385972663331 bayes_pls_golite062009
  • nicotinic acetylcholine-activated cation-selective channel activity
    		•  6.68325610876107 bayes_pls_golite062009
  • ligand-gated channel activity
    		•  6.54466087904138 bayes_pls_golite062009
  • ligand-gated ion channel activity
    		•  6.54466087904138 bayes_pls_golite062009
  • neurotransmitter binding
    		•  6.11782125343012 bayes_pls_golite062009
  • neurotransmitter receptor activity
    		•  5.97698567435878 bayes_pls_golite062009
  • extracellular ligand-gated ion channel activity
    		•  5.96773594514842 bayes_pls_golite062009
  • excitatory extracellular ligand-gated ion channel activity
    		•  5.96773594514842 bayes_pls_golite062009
  • acetylcholine binding
    		•  5.82006373570659 bayes_pls_golite062009
  • acetylcholine receptor activity
    		•  5.72083104614502 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  5.4080353535498 bayes_pls_golite062009
  • receptor activity
    		•  5.11329651194787 bayes_pls_golite062009
  • transporter activity
    		•  5.11262082564788 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  5.03439798256257 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  4.91314874981447 bayes_pls_golite062009
  • molecular transducer activity
    		•  4.12549692767753 bayes_pls_golite062009
  • signal transducer activity
    		•  4.12549692767753 bayes_pls_golite062009
  • amine binding
    		•  3.99316633473025 bayes_pls_golite062009
  • G-protein coupled receptor activity
    		•  3.09231388867595 bayes_pls_golite062009
  • chloride channel regulator activity
    		•  2.30670892326006 bayes_pls_golite062009
  • binding
    		•  2.2810963754869 bayes_pls_golite062009
  • G-protein coupled amine receptor activity
    		•  1.37431949258757 bayes_pls_golite062009
    		• 1.15330735898282 bayes_pls_golite062009
  • channel regulator activity
    		•  1.13923307634251 bayes_pls_golite062009
  • beta-amyloid binding
    		•  1.10082189665627 bayes_pls_golite062009
  • toxin binding
    		•  0.91098263903324 bayes_pls_golite062009
  • protein binding
    		•  0.406954670483187 bayes_pls_golite062009
  • drug binding
    		•  0.1024174756655 bayes_pls_golite062009
  • serotonin receptor activity
    		•  0.0879353619248899 bayes_pls_golite062009
    3
    Term Confidence Notes
  • ion transmembrane transporter activity
    		•  6.77040948038207 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  6.54632954876879 bayes_pls_golite062009
  • channel activity
    		•  6.54632954876879 bayes_pls_golite062009
  • ion channel activity
    		•  6.54081091818708 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  6.53282135350974 bayes_pls_golite062009
  • gated channel activity
    		•  6.45068814746887 bayes_pls_golite062009
  • cation channel activity
    		•  6.44482558831924 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  6.43078004966793 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  6.36378031146392 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  6.29833803742064 bayes_pls_golite062009
  • nicotinic acetylcholine-activated cation-selective channel activity
    		•  5.96791824940609 bayes_pls_golite062009
  • ligand-gated channel activity
    		•  5.87382805697746 bayes_pls_golite062009
  • ligand-gated ion channel activity
    		•  5.87382805697746 bayes_pls_golite062009
  • neurotransmitter binding
    		•  5.54157394911009 bayes_pls_golite062009
  • neurotransmitter receptor activity
    		•  5.41758713081321 bayes_pls_golite062009
  • excitatory extracellular ligand-gated ion channel activity
    		•  5.240450320112 bayes_pls_golite062009
  • extracellular ligand-gated ion channel activity
    		•  5.240450320112 bayes_pls_golite062009
  • acetylcholine binding
    		•  5.15331199329751 bayes_pls_golite062009
  • acetylcholine receptor activity
    		•  5.06338031097833 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  5.04630162986246 bayes_pls_golite062009
  • receptor activity
    		•  4.78457368651236 bayes_pls_golite062009
  • transporter activity
    		•  4.73973512233464 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  4.64706802893702 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  4.51057101522234 bayes_pls_golite062009
  • signal transducer activity
    		•  3.87903570844696 bayes_pls_golite062009
  • molecular transducer activity
    		•  3.87903570844696 bayes_pls_golite062009
  • amine binding
    		•  3.42320290513776 bayes_pls_golite062009
  • G-protein coupled receptor activity
    		•  3.02725446389008 bayes_pls_golite062009
  • binding
    		•  2.18972894667097 bayes_pls_golite062009
  • chloride channel regulator activity
    		•  1.74675124590896 bayes_pls_golite062009
  • G-protein coupled amine receptor activity
    		•  1.12733413163727 bayes_pls_golite062009
    		• 0.859417963545377 bayes_pls_golite062009
  • channel regulator activity
    		•  0.842700523410834 bayes_pls_golite062009
  • beta-amyloid binding
    		•  0.704684393278994 bayes_pls_golite062009
  • toxin binding
    		•  0.48890633184828 bayes_pls_golite062009
  • protein binding
    		•  0.414375631224425 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle