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View Structure Prediction Details

Protein: l(2)k01209-PA
Organism: Drosophila melanogaster
Length: 561 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for l(2)k01209-PA.

Description E-value Query
Range
Subject
Range
gi|220953536, gi... - gi|220953536|gb|ACL89311.1| l(2)k01209-PB [synthetic construct], gi|220943522|gb|ACL84304.1| l(2)k01...
l(2)k01209-PC, l... - The gene lethal (2) k01209 is referred to in FlyBase by the symbol Dmel\l(2)k01209 (CG4798, FBgn0022...
448.0 [0..23] [561..88]

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Predicted Domain #1
Region A:
Residues: [1-293]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVTQTKQIK FYNPSSSASS DSDDRSLSDV TEQLYVDPYA DLSNGLPGDL NCCPASPTTV  60
   61 PAKASLDSPL KRSGRRQRTT SIGNQTTTAN PSECIIRANN RTIYTAGRPP WYNCAGQQVE 120
  121 PFVIGICGGS ASGKTTVAEK IIESLDVPWV TLLSMDCFYK ILNEKQHEQA LINEYNFDHP 180
  181 DAFDIELLLD VLTKLKEGRK VEVPVYNFVT HGRESQTKTM YGANVIIFEG ILTFHSPEVL 240
  241 KLLDMKIFVD TDPDIRLARR LRRDISQRGR DLKGVLKQYL NMVKPSYCNY IAP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 44.522879
Match: 1esmA
Description: Pantothenate kinase PanK
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
nucleobase, nucleoside, nucleotide kinase activity 3.66392587433723 bayes_pls_golite062009
nucleotide kinase activity 2.24094813695083 bayes_pls_golite062009
binding 2.20860426568814 bayes_pls_golite062009
kinase activity 2.0779386406753 bayes_pls_golite062009
phosphotransferase activity, phosphate group as acceptor 1.96697952975573 bayes_pls_golite062009
nucleic acid binding 1.08697924060619 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
DNA binding 0.702147676354075 bayes_pls_golite062009
adenylate kinase activity 0.447752711852745 bayes_pls_golite062009
transcription regulator activity 0.287777990975748 bayes_pls_golite062009
protein binding 0.193768631623192 bayes_pls_golite062009
helicase activity 0.0775311459068899 bayes_pls_golite062009
nucleotide binding 0.0593371872166591 bayes_pls_golite062009
purine nucleotide binding 0.0285347443435678 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [294-343]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TMAHADIIVP RGGDNKVAIH LIVQHVHTQL QLRGFKLRET LANSYKDQPM 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 42.69897
Match: 1xrjA
Description: Rapid structure determination of human uridine-cytidine kinase 2 using a conventional laboratory X-ray source and a single samarium derivative
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [344-561]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PHSLHLLHPT PQIKGLHTFI RCRNTSRDEF IFYSKRLIRL VIEYALSLFP FKKTTVETPQ  60
   61 GVLYEGKRME SRKICGVSIL RAGETMEQAV CDVCKDIRIG KILIQTNLKT GEPELYYLRL 120
  121 PKDIKDYKVI LMDATVATGA AAMMAIRVLL DHDVPEDNII LASLLMAEIG VHSIAYAFPK 180
  181 VKIVTSALDP EINSKFYVIP GIGNFGDRYF GTEPSDEY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 51.154902
Match: 1bd3D
Description: Uracil PRTase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
uracil phosphoribosyltransferase activity 3.97944228585882 bayes_pls_golite062009
transferase activity, transferring glycosyl groups 3.91023158228049 bayes_pls_golite062009
adenine phosphoribosyltransferase activity 3.07502596276449 bayes_pls_golite062009
hypoxanthine phosphoribosyltransferase activity 2.97347277288245 bayes_pls_golite062009
transferase activity 2.73727660668741 bayes_pls_golite062009
transferase activity, transferring pentosyl groups 2.53679639481311 bayes_pls_golite062009
catalytic activity 2.30431811394775 bayes_pls_golite062009
nucleobase binding 1.70525606708275 bayes_pls_golite062009
purine binding 1.24786927434743 bayes_pls_golite062009
ribose phosphate diphosphokinase activity 0.947697983706416 bayes_pls_golite062009
binding 0.847513071499147 bayes_pls_golite062009
diphosphotransferase activity 0.749909396904601 bayes_pls_golite062009
nucleic acid binding 0.552133387792911 bayes_pls_golite062009
DNA binding 0.439741935655503 bayes_pls_golite062009
transcription regulator activity 0.396538943915776 bayes_pls_golite062009
amidophosphoribosyltransferase activity 0.360901350940423 bayes_pls_golite062009
orotate phosphoribosyltransferase activity 0.148898393751978 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle