YRC Public Data Repository - Protein Structure Prediction

Protein:	CASP3
Organism:	Homo sapiens
Length:	277 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CASP3.

Description	E-value	Query Range	Subject Range
gi\|2137063 - gi\|2137063\|pir\|\|S64710 cysteine proteinase (EC 3.4.22.-) CPP32 - Chinese hamster	0.0	[1..277]	[1..277]
CASP3_CRILO, ICE... - (Q60431) Caspase-3 precursor (EC 3.4.22.-) (CASP-3) (Apopain) (Cysteine protease CPP32) (Yama protei... gi\|1244444 - gi\|1244444\|gb\|AAB01511.1\| CPP-32 gene product CASP3_MESAU - Caspase-3 OS=Mesocricetus auratus GN=CASP3 PE=2 SV=1	0.0	[1..277]	[1..277]
CASP3_MOUSE - Caspase-3 OS=Mus musculus GN=Casp3 PE=1 SV=1	0.0	[1..277]	[1..277]
gi\|30585109, gi\|... - gi\|61369707\|gb\|AAX43378.1\| caspase 3 [synthetic construct], gi\|30585109\|gb\|AAP36827.1\| Homo sapiens ...	0.0	[1..277]	[1..277]
CASP3_PANTR - Caspase-3 OS=Pan troglodytes GN=CASP3 PE=2 SV=1	0.0	[1..277]	[1..277]
CASP3_RAT - Caspase-3 OS=Rattus norvegicus GN=Casp3 PE=2 SV=2	0.0	[1..277]	[1..277]
gi\|2780971, gi\|2... - gi\|561666\|gb\|AAA65015.1\| cysteine protease CPP32 isoform alpha, gi\|2780973\|pdb\|1CP3\|B Chain B, Cryst...	0.0	[1..277]	[1..277]
CASP3_RABIT - Caspase-3 OS=Oryctolagus cuniculus GN=CASP3 PE=2 SV=1	0.0	[1..277]	[1..277]
CASP3_FELCA - Caspase-3 OS=Felis catus GN=CASP3 PE=2 SV=1	0.0	[1..277]	[1..277]

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Predicted Domain #1

Region A:
Residues: [1-277]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MENTENSVDS KSIKNLEPKI IHGSESMDSG ISLDNSYKMD YPEMGLCIII NNKNFHKSTG  60
   61 MTSRSGTDVD AANLRETFRN LKYEVRNKND LTREEIVELM RDVSKEDHSK RSSFVCVLLS 120
  121 HGEEGIIFGT NGPVDLKKIT NFFRGDRCRS LTGKPKLFII QACRGTELDC GIETDSGVDD 180
  181 DMACHKIPVE ADFLYAYSTA PGYYSWRNSK DGSWFIQSLC AMLKQYADKL EFMHILTRVN 240
  241 RKVATEFESF SFDATFHAKK QIPCIVSMLT KELYFYH

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	104.0
Match:	1cp3A
Description:	Apopain (caspase-3, cpp32)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
peptidase activity	3.24815349282067	bayes_pls_golite062009
protein binding	2.96725373477762	bayes_pls_golite062009
binding	2.91261616137775	bayes_pls_golite062009
cyclin-dependent protein kinase regulator activity	2.60103365510479	bayes_pls_golite062009
hydrolase activity	2.45602706385958	bayes_pls_golite062009
cysteine-type peptidase activity	2.37850336421322	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	2.07426831021634	bayes_pls_golite062009
cysteine-type endopeptidase activity	1.82979469421101	bayes_pls_golite062009
endopeptidase activity	1.58137850574981	bayes_pls_golite062009
cyclin-dependent protein kinase inhibitor activity	1.38256499817012	bayes_pls_golite062009
catalytic activity	1.03907950272772	bayes_pls_golite062009
enzyme regulator activity	0.0737251792690711	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: