YRC Public Data Repository - Protein Structure Prediction

Protein:	MDTP_ECOLI, YJCP...
Organism:	Escherichia coli
Length:	488 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MDTP_ECOLI, YJCP....

Description	E-value	Query Range	Subject Range
gi\|71488678, gi\|... - gi\|71545481\|ref\|ZP_00666412.1\| RND efflux system, outer membrane lipoprotein, NodT [Syntrophobacter ...	351.0	[0..3]	[480..206]
gi\|85858611, gi\|... - gi\|85858611\|ref\|YP_460813.1\| type I secretion outer membrane protein [Syntrophus aciditrophicus SB],...	341.0	[0..8]	[484..38]
gi\|71736997, gi\|... - gi\|71736997\|ref\|YP_276145.1\| NodT family outer membrane efflux lipoprotein [Pseudomonas syringae pv....	338.0	[0..9]	[479..3]
gi\|23471294, gi\|... - gi\|66047236\|ref\|YP_237077.1\| RND efflux system, outer membrane lipoprotein, NodT [Pseudomonas syring...	337.0	[0..9]	[479..3]
gi\|28854693, gi\|... - gi\|28871442\|ref\|NP_794061.1\| outer membrane efflux protein [Pseudomonas syringae pv. tomato str. DC3... tr\|Q87X83\|Q87X83... - Outer membrane efflux protein OS=Pseudomonas syringae pv. tomato (strain DC3000) GN=PSPTO_4305 PE=4 ...	335.0	[0..9]	[479..3]
gi\|53753478, gi\|... - gi\|54293646\|ref\|YP_126061.1\| hypothetical protein lpl0699 [Legionella pneumophila str. Lens], gi\|537...	333.0	[0..10]	[480..3]
gi\|67981567, gi\|... - gi\|95930203\|ref\|ZP_01312941.1\| Hydrophobe/amphiphile efflux-1 HAE1 [Desulfuromonas acetoxidans DSM 6...	333.0	[0..3]	[486..1036]
gi\|71741812, gi\|... - gi\|71837530\|ref\|ZP_00677294.1\| RND efflux system, outer membrane lipoprotein, NodT [Pelobacter propi...	331.0	[0..2]	[478..1]
gi\|94731686, gi\|... - gi\|94987437\|ref\|YP_595370.1\| outer membrane efflux protein [Lawsonia intracellularis PHE/MN1-00], gi...	331.0	[0..8]	[480..1]

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Predicted Domain #1

Region A:
Residues: [1-488]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MINRQLSRLL LCSILGSTTL ISGCALVRKD SAPHQQLKPE QIKLADDIHL ASSGWPQAQW  60
   61 WKQLNDPQLD ALIQRTLSGS HTLAEAKLRE EKAQSQADLL DAGSQLQVAA LGMLNRQRVS 120
  121 ANGFLSPYSM DAPALGMDGP YYTEATVGLF AGLDLDLWGV HRSAVAAAIG AHNAALAETA 180
  181 AVELSLATGV AQLYYSMQAS YQMLDLLEQT HDVIDYAVKA HQSKVAHGLE AQVPFHGARA 240
  241 QILAVDKQIV AVKGQITETR ESLRALIGAG ASDMPEIRPV ALPQVQTGIP ATLSYELLAR 300
  301 RPDLQAMRWY VQASLDQVDS ARALFYPSFD IKAFFGLDSI HLHTLFKKTS RQFNFIPGLK 360
  361 LPLFDGGRLN ANLEGTRAAS NMMIERYNQS VLNAVRDVAV NGTRLQTLND EREMQAERVE 420
  421 ATRFTQRAAE AAYQRGLTSR LQATEARLPV LAEEMSLLML DSRRVIQSIQ LMKSLGGGYQ 480
  481 AGPVVEKK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	81.0
Match:	1wp1A
Description:	Crystal structure of the drug-discharge outer membrane protein, OprM
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
drug transmembrane transporter activity	4.81710579303325	bayes_pls_golite062009
	4.35844117790122	bayes_pls_golite062009
	4.29225678658868	bayes_pls_golite062009
transporter activity	4.2806100513341	bayes_pls_golite062009
transmembrane transporter activity	2.91628575119399	bayes_pls_golite062009
porin activity	0.960340223825989	bayes_pls_golite062009
binding	0.666039242029224	bayes_pls_golite062009
channel activity	0.517545908208242	bayes_pls_golite062009
passive transmembrane transporter activity	0.517545908208242	bayes_pls_golite062009
efflux transmembrane transporter activity	0.381147202210091	bayes_pls_golite062009
protein binding	0.0827883348198969	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: